Molekylär cancer- och stamcellsbehandling

This page in English

Information om forskningen i vår grupp finns på engelska

Gruppmedlemmar

Theresa Vincent Forskargruppsledare
Jennifer Feenstra Postdoc
Varsha Prakash Doktorand
Theresa Mader FOU-praktikant

Gruppmedlemmar utanför KI

Linda Bojmar Doktorand, bihandledning tillsammans med Dr Lyden, Weill Cornell Medical College of Cornell University 
Randall Dass Doktorand, bihandledning tillsammans med Dr Blanchard, Weill Cornell Medical College of Cornell University, USA 

Alumni

  • Jacob Jansson
  • Iris Muller
  • Tianyi Song
  • Rithika Venkatesh
  • Joel Östblom

Anslagsgivare

Samarbeten

Theresa Vincents forskningspresentation vid Department of Physiology and Biophysics, Cornell University, Weill Cornell Medical College, New York, USA. 

Press

Närkoll på Ribosomerna. Medicinsk Vetenskap nr 2 2018 (sid. 13)

Därför skyddar särskild gen mot aggressiv bröstcancer. Nyhet från KI. 2016-08-07. 

Utvalda publikationer

Face morphogenesis is promoted by Pbx-dependent EMT via regulation of during frontonasal prominence fusion.
Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, et al
Development 2018 03;145(5):

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.
Parks M, Kurylo C, Dass R, Bojmar L, Lyden D, Vincent C, et al
Sci Adv 2018 Feb;4(2):eaao0665

EMT, inflammation and metastasis.
Vincent C, Fuxe J
Semin. Cancer Biol. 2017 12;47():168-169

Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells.
Sharma A, Xu Y, Sung B, Vincent C, Worgall T, Worgall S
Cell. Microbiol. 2017 02;19(2):

Membrane depolarizing channel blockers induce selective glioma cell death via impaired nutrient transport and unfolded protein / amino acid responses.
Niklasson M, Maddalo G, Zuzana Sramkova Z, Mutlu E, Wee S, Sekyrova S, Schmidt L, Fritz N, Ivar Dehnisch I, Kyriatzis G, Krafcikova M, Carson BBC, Feenstra J, Marinescu V, Segerman A, Mulder J, Haraldsson M, Gustavsson AL, Hammarström L, Jenmalm, Jensen A, Uhrbom L, Altelaar A.F. M, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Per Øyvind Enger PO, Andäng M.
Cancer Res. (2017) Jan 13

Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.
Dass R, Sarshad A, Carson B, Feenstra J, Kaur A, Obrdlik A, et al
PLoS Genet. 2016 Aug;12(8):e1006217

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis.
Ferguson A, Wang L, Altman R, Terry D, Juette M, Burnett B, et al
Molecular Cell. 2015, 60:1–12

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.
Stadler S, Vincent C, Fedorov V, Patsialou A, Cherrington B, Wakshlag J, et al
Proc. Natl. Acad. Sci. U.S.A. 2013 Jul;110(29):11851-6

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Vincent T, Neve E, Johnson J, Kukalev A, Rojo F, Albanell J, et al
Nat. Cell Biol. 2009 Aug;11(8):943-50

The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.
Vincent T, Kukalev A, Andäng M, Pettersson R, Percipalle P
Oncogene 2008 Sep;27(39):5254-9

Neutralized adenovirus-immune complexes can mediate effective gene transfer via an Fc receptor-dependent infection pathway.
Leopold P, Wendland R, Vincent T, Crystal R
J. Virol. 2006 Oct;80(20):10237-47

Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells. 
Vincent T, Pettersson RF, Crystal RG, Leopold PL.
J Virol. (2004) 78:8047-58.

Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity.
Vincent T, Harvey B, Hogan S, Bailey C, Crystal R, Leopold P
J. Virol. 2001 Feb;75(3):1516-21

Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver.
Bezdicek P, Worgall S, Kovesdi I, Kim M, Park J, Vincent T, et al
Blood 1999 Nov;94(10):3448-55

Review

Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes.
Fuxe J, Vincent T, Garcia de Herreros A
Cell Cycle 2010 Jun;9(12):2363-74

A new paradigm for mechanobiological mechanisms in tumor metastasis.
Torzilli P, Bourne J, Cigler T, Vincent C
Semin. Cancer Biol. 2012 Oct;22(5-6):385-95

A dialogue with Dr. Craig B. Thompson about metabolism and its relevance for tumor growth, progression and metastasis.
Vincent C, Dass R, Thompson C
Semin. Cancer Biol. 2012 Oct;22(5-6):484-8

In memory of Professor Ralf Pettersson (1945-2011) and Professor Lennart Philipson (1929-2011).
Vincent T
Semin. Cancer Biol. 2012 Oct;22(5-6):359-488

Publicerade kommentarer på gruppens vetenskapliga artiklar

News and Views on; Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. 
Cell Cycle (2010) 12: 2363-2374 

Integration of transcriptional signals at the tumor cell invasive front.
Meulmeester E, ten Dijke P
Cell Cycle 2010 Jul;9(13):2499-500

A spotlight on regulatory networks connecting EMT and cancer stem cells.
Zavadil J
Cell Cycle 2010 Aug;9(15):2927

Kontakta forskargruppsledaren

Forskargruppsledare

Theresa Vincent

Enhet: Vincent Teresa grupp - Molekylär cancer- och stamcellsbehandling
E-post: theresa.vincent@ki.se