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Farmakologisk neurokemi

Forskningen i vår grupp handlar om att utveckla och tillämpa tekniker för att hitta kemiska signaler i hjärnan och andra organ med hjälp av mikrodialys, biosensorer och relaterade bioanalytiska metoder.


Jan Kehr – Forskargruppsledare

Takashi Yoshitake – Senior researcher

Shimako Yoshitake – Senior researcher


Senaste publikationer

The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Yoshitake S, Kehr J
Br. J. Pharmacol. 2010 Feb;159(3):659-68

Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection.
Ichinose F, et al.
Chromatographia 70: 575-580, 2009

Intra- and intermolecular interaction ECL study of novel ruthenium tris-bipyridyl complexes with different amine reductants.
Sun S, Yang Y, Liu F, Fan J, Peng X, Kehr J, et al
Dalton Trans 2009 Oct;(38):7969-74

The role of 5-HT(1A) receptors in learning and memory.
Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, et al
Behav. Brain Res. 2008 Dec;195(1):54-77

From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission.
Fuxe K, Dahlström A, Höistad M, Marcellino D, Jansson A, Rivera A, et al
Brain Res Rev 2007 Aug;55(1):17-54

Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: a microdialysis study.
Hu XJ, Wang FH, Stenfors C, Ogren SO, Kehr J
Eur Neuropsychopharmacol 2007 Sep;17(9):580-6

Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation.
Kehr J, Hu XJ, Goiny M, Scheller DK
J Neural Transm (Vienna) 2007 ;114(8):1027-31

Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection.
Kehr J, Hu XJ, Yoshitake T, Scheller D
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007 Jan;845(1):109-13

The neuropeptide galanin as an in vivo modulator of brain 5-HT1A receptors: possible relevance for affective disorders.
Ogren SO, Razani H, Elvander-Tottie E, Kehr J
Physiol. Behav. 2007 Sep;92(1-2):172-9

Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex: the role of 5-HT1A receptors.
Weikop P, Kehr J, Scheel-Krüger J
J. Psychopharmacol. (Oxford) 2007 Nov;21(8):795-804

Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain.
Weikop P, Yoshitake T, Kehr J
Eur Neuropsychopharmacol 2007 Oct;17(10):658-71


Jan Kehr

Annan grund
C3 Fysiologi och farmakologi