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Cellulär muskelfunktion

Vår forskargrupp undersöker mekanismerna bakom den förändrade muskelfunktionen hos en frisk muskel under uttröttning. Vi undersöker också orsaker till försämrad muskelfunktion vid ett flertal mycket vanliga sjukdomstillstånd.

En central del i vår grupps forskning är studier av cellulära orsaker till att skelettmuskler blir svagare och långsammare vid uttröttning. Med utgångspunkt från dessa studier undersöker vi även grundläggande mekanismer för hur muskelceller anpassar sig till träning och därmed blir mer uthålliga eller starkare.

Vi studerar även motsatsen, dvs varför muskler blir svagare och mindre uthålliga vid olika sjukdomstillstånd, t ex mitokondriella myopatier. En stor del vår forskning kretsar kring det komplexa samspelet mellan kraftproduktion, cellulär Ca2+-hantering, mitokondriefunktion och fria radikaler (reactive oxygen/nitrogen species).

Gruppmedlemmar

Joseph Bruton – Forskare

Aniek Garritsen Student

Hans-Christer Holmberg Anknuten

Abram Katz Anknuten

Jan Lännergren Anknuten

Maja Schlittler Doktorand

Arturo Eduardo Uribe Gonzalez Doktorand

Håkan Westerblad Professor, research group leader

Victoria Wyckelsma Postdoc

Anslagsgivare

Senaste publikationer

Post-exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle.
Cheng AJ, Willis SJ, Zinner C, Chaillou T, Ivarsson N, Ørtenblad N, et al
J. Physiol. (Lond.) 2017 12;595(24):7413-7426

Prolonged force depression after mechanically demanding contractions is largely independent of Ca2+ and reactive oxygen species.
Kamandulis S, de Souza Leite F, Hernández A, Katz A, Brazaitis M, Bruton JD, et al
FASEB J. 2017 11;31(11):4809-4820

Intramuscular Contributions to Low-Frequency Force Potentiation Induced by a High-Frequency Conditioning Stimulation.
Cheng AJ, Neyroud D, Kayser B, Westerblad H, Place N
Front Physiol 2017 ;8():712

Mechanical isolation, and measurement of force and myoplasmic free [Ca2+] in fully intact single skeletal muscle fibers.
Cheng AJ, Westerblad H
Nat Protoc 2017 Sep;12(9):1763-1776

Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat.
Himori K, Tatebayashi D, Kanzaki K, Wada M, Westerblad H, Lanner JT, et al
PLoS ONE 2017 ;12(6):e0179925

Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular Ca2+ Handling.
Cheng AJ, Place N, Westerblad H
Cold Spring Harb Perspect Med 2018 02;8(2):

Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.
Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner JT, et al
PLoS ONE 2017 ;12(2):e0169146

Dietary nitrate markedly improves voluntary running in mice.
Ivarsson N, Schiffer TA, Hernández A, Lanner JT, Weitzberg E, Lundberg JO, et al
Physiol. Behav. 2017 01;168():55-61

The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.
Hwee DT, Cheng AJ, Hartman JJ, Hinken AC, Lee K, Durham N, et al
J. Physiol. (Lond.) 2017 03;595(5):1657-1670

The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome.
Llano-Diez M, Sinclair J, Yamada T, Zong M, Fauconnier J, Zhang SJ, et al
PLoS ONE 2016 ;11(12):e0167090

Mechanisms of force depression caused by different types of physical exercise studied by direct electrical stimulation of human quadriceps muscle.
Skurvydas A, Mamkus G, Kamandulis S, Dudoniene V, Valanciene D, Westerblad H
Eur. J. Appl. Physiol. 2016 Dec;116(11-12):2215-2224

Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.
Llano-Diez M, Cheng AJ, Jonsson W, Ivarsson N, Westerblad H, Sun V, et al
Crit Care 2016 Aug;20(1):254

Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles.
Neyroud D, Cheng AJ, Bourdillon N, Kayser B, Place N, Westerblad H
Front Physiol 2016 ;7():252

Dietary nitrate improves cardiac contractility via enhanced cellular Ca²⁺ signaling.
Pironti G, Ivarsson N, Yang J, Farinotti AB, Jonsson W, Zhang SJ, et al
Basic Res. Cardiol. 2016 May;111(3):34

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.
Schlittler M, Goiny M, Agudelo LZ, Venckunas T, Brazaitis M, Skurvydas A, et al
Am. J. Physiol., Cell Physiol. 2016 May;310(10):C836-40

Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery.
Cheng AJ, Yamada T, Rassier DE, Andersson DC, Westerblad H, Lanner JT
J. Physiol. (Lond.) 2016 09;594(18):5149-60

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.
Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng AJ, et al
Proc. Natl. Acad. Sci. U.S.A. 2015 Dec;112(50):15492-7

Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy.
Gineste C, Hernandez A, Ivarsson N, Cheng AJ, Naess K, Wibom R, et al
Hum. Mol. Genet. 2015 Dec;24(23):6580-7

Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes.
Olsson K, Cheng AJ, Alam S, Al-Ameri M, Rullman E, Westerblad H, et al
Skelet Muscle 2015 ;5():26

Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment.
Yamada T, Abe M, Lee J, Tatebayashi D, Himori K, Kanzaki K, et al
Skelet Muscle 2015 ;5():20

Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres.
Cheng AJ, Bruton JD, Lanner JT, Westerblad H
J. Physiol. (Lond.) 2015 Jan;593(2):457-72

α-Actinin-3: why gene loss is an evolutionary gain.
Ivarsson N, Westerblad H
PLoS Genet. 2015 Jan;11(1):e1004908

Populärvetenskapliga artiklar

WESTERBLAD, H. (2010) Mjölksyra påverkar inte musklernas function. Svensk IdrottsMedicin 1, 8-13.

IVARSSON, N., BRUTON, J.D. & WESTERBLAD, H. (2011) Endurance training-overtraining: a fine-tuned balance that depends on Ca2+. Physiology News 83, 18-20.

WESTERBLAD, H. & LANNER J.T. (2015) Muskelsvaghet vid reumatoid artrit. BestPractice 24, 14-16.

WESTERBLAD, H. (2015) Antioxidanter förbättrar inte återhämtningen. Svensk Idrottsforskning, Idrottsforskning.se Dec 14.

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