CfA seminar: Update on Specialised Pro-Resolving Lipid Mediators
Speaker: Prof. Charles Serhan, Harvard Medical School, Boston, USA. Coffee and tea served from 15:30. Welcome!
CfA seminar "Update on Specialised Pro-Resolving Lipid Mediators"
Speaker: Prof. Charles Serhan, Department of Anesthesiology, Perioperative and Pain Medicine and Department of Oral Medicine, Infection and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
About the speaker:
Research in the Serhan laboratory focuses on structural elucidation of bioactive small molecules that activate the resolution of acute inflammation. The overall mission is “To identify novel mediators, pathways, and cellular targets critical in promoting resolution of inflammation and reperfusion tissue injury and their relation to human disease.” The studies currently focus on structural elucidation of novel molecules and pathways that serve as pro-resolving and/or endogenous anti-inflammatory chemical signals.
Prof. Serhan and colleagues elucidated several new families of lipid-derived, local-acting chemical mediators, coined the Resolvins and Protectins, and most recently Maresins, that stimulate resolution of inflammatory responses. They also designed novel therapeutic approaches using these structures as biotemplates. New therapeutic approaches built with the knowledge of these signaling pathways could be more potent, selective and better tolerated since they are based on structures naturally evolved in these processes. Several of these new designer therapeutics have already been shown to be effective in human disease.