High impact publications

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Each year, researchers at Karolinska Institutet publish approx. 5000 papers in peer-reviewed scientific journals. Here we list the most recent publications with one or several authors from KI in high impact journals (JIF 15 and above). 

Identification of spatial expression trends in single-cell gene expression data
Edsgärd D, Johnsson P, Sandberg S
Nature Methods (2018) Online 19 April. Brief Communication.

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single Cell Sequencing
Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, Crosetto N, Foukakis T, Navin NE
Cell (2018) Online 19 April. Article.
On KI News: Aggressive breast cancer has resistant tumour cells already prior to chemotherapy

Human Adult Neurogenesis: Evidence and Remaining Questions
Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J
Cell Stem Cell (2018) Online 19 April. Minireview.

Association Between Muscular Strength and Cognition in People With Major Depression or Bipolar Disorder and Healthy Controls
Firth J, Bredon JA, Vancampfort D, Schuch FB, Hallgren M, Veronese N, Yung AR, Sarris J
JAMA Psychiatry (2018) Online 18 April. Original Investigation.

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Lund H, Pieber M, Parsa R, Grommisch D, Ewing E, Kular L, Han J, Zhu K, Nijssen J, Hedlund E, Needhamsen M, Ruhrmann S, Guerreiro-Cacais AO, Berglund R, Forteza MJ, Ketelhuth DFJ, Butovsky O, Jagodic M, Zhang XM, Harris RA
Nature Immunology (2018) Online 16 April. Article.
On KI News: New disease model to facilitate development of ALS and MS drugs

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms
Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL,
Science Translational Medicine (2018) Online 11 April. Research Article.

The State of US Health, 1990-2016
Mokdad AH, Ballestros K, Echko M et al.
JAMA (2018) Online 10 April. Original Investigation.

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Small  KS, Todorcevic M, Civelek M et al.
Nature Genetics (2018) Online 9 April. Article.

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
Gusev A, Mancuso N, Won H et al.
Nature Genetics (2018) Online 9 April. Article.

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
Benador IY,  Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF,  Cinti S,  Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE,  Liesa M, Shirihai OS.
Cell Metabolism (2018) Online 3 April. Article.

The FIH (Factor Inhibiting HIF) asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia
Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCS, Branco CM, Rundqvist H, Peet DJ, Johnson RS
Cell Metabolism (2018) Online 3 April. Article.
On KI News: Study shows how muscles regulate their oxygen consumption

Addressing social determinants to end tuberculosis
Wingfield T, Tovar MA, Datta S, Saunders MJ, Evans CA
The Lancet (2018) Online 24 March. Comment.

The impact of social protection and poverty elimination on the End TB strategy targets: a statistical model of Sustainable Development Goal
Carter DJ, Glaziou P, Lönnroth K, Siroka A, Floyd K, Weil D, Raviglione M, Houben RM, Boccia D.
Lancet Global Health (2018) Online 23 March. Article.

Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study
Zignol M, Cabibbe AM, Dean AS, Glaziou P, Alikhanova N, Ama C, Andres S, Barbova A, Borbe-Reyes A, Chin DP, Cirillo DM, Colvin C, Dadu A, Dreyer A, Driesen M, Gilpin C, Hasan R, Hasan Z, Hoffner S, Hussain A, Ismail N, Kamal SMM, Khanzada FM, Kimerling M, Kohl TA, Mansjö M, Miotto P, Mukadi YD, Mvusi L, Niemann S, Omar SV, Rigouts L, Schito M, Sela I, Seyfaddinova M, Skenders G, Skrahina A, Tahseen S, Wells WA, Zhurilo A, Weyer K, Floyd K, Raviglione MC.
Lancet Infectious Disease (2018) Online 22 March. Article.

Autoimmune Polyendocrine Syndromes
Husebye ES, Anderson, Kämpe O
NEJM (2018) Online 21 March. Review Article.

Circadian organization of the genome
Diettrich C, de Lima M, Göndör A
Science (2018) Online 16 March. Perspective.

Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling
Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saa LHl, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJB, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K
Nature Medicine (2018) Online 12 March. Article.
On KI News: Aggressive breast cancer can be transformed into a treatable form

Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
Monda T, Kumar Juvvuna P, Kirkeby A et al
Cancer Cell (2018) Online 12 March. Article.
On KI News: New biomarkers for neuroblastoma

​Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study
Pasternak B, Inghammar M, Svanström H
BMJ (2018) Online 8 March. Research.
KI News: Fluoroquinolones linked to increased risk of aortic disease

Interactions within the Pancreatic Islet Determine the Glycemic Set Point
Rodriguez-Diaz R, Molano RD, Weitz JR, Abdulreda MD, Berman DM, Leibiger B, Leibiger IB, Kenyon NS, Ricordi C, Pileggi A, Caicedo A, Berggren PO
Cell Metabolism (2018) Online 6 March. Clinical and Translational Report. 
On KI News: The body’s “glucostat” identified

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Oliveira Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C, Frisén J
Cell (2018) Online 1 March. Article.
On KI News: Promising therapeutic approach for spinal cord injuries

Rebooting Human Immunology
Davis MM, Brodin P
Annual Review of Immunology (2018) Online 28 February. Review in Advance.

Real-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients with Bipolar Disorder
Lähteenvuo M, Tanskanen A, Taipale H, Hoti F, Vattulainen P, Vieta E, Tiihonen J
JAMA Psychiatry (2018) Online 28 February. Original Investigation.
On KI News: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalisation

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background
Pardiñas AF, Holmans P, Pocklington AJ et al.
Nature Genetics (2018) Online 26 February, Article.

DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Xu CJ et al. From KI: Söderhäll C, Gruzieva O, Kebede Merid S, Kumar A, Pershagen G, Reinius L, Alenius H, Fyhrquist H, Kere J, Melén E
Lancet Respiratory Medicine (2018) Online 23 February. Article.
On KI News: Asthmatics show DNA changes in immune cells

Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study
Khandaker GM, Dalman C, Kappelmann N, Stochl J, Dal H, Kosidou K, Jones PB, Karlsson H
JAMA Psychiatry (2018) Online 14 February, Original Investigation.

A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck M, He L, Andaloussi Mäe M, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T,  Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C
Nature (2018) Online 14 February. Article.
On KI News: Atlas of brain blood vessels provides fresh clues to brain diseases

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford WC, Peng X, Hägg Olofsson M, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Martinsson Ahlzén HS, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ
Science Translational Medicine (2018) Online 14 February, Research Article.
On KI News:  Possible new principle for cancer therapy

Outcome measures in coeliac disease trials: the Tampere recommendations
Ludvigsson JF, Ciacci C, Green PH et al
Gut (2018) Online 13 February. Original Article.

Ezh2 and Runx1 mutations collaborate to initiate lympo-myeloid leukemia in earlly thymic progenitors
Booth C, Barkas N, Wen N, Boukarabila H, Soilleux E, Giotopoulos G, Farmoud N, Giustacchini A, Ashely N, Carrelha J, Jamieson L, Atkinson D, Bouriez-Jones T, Prinjha R, Milne TA, Teachey DT, Papaemmanuil E, Huntly BJP, Jacobsen SE, Mead AJ 
Cancer Cell (2018) Online 12 February. Article.

Toward an optically controlled brain
Feliu N, Neher E, Parak WJ
Science (2018) Online 9 February. Perspective.

The Human Transcription Factors
Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen X, Taipale J, Hughes TR, Weirauch MT
Cell (2018) Online 8 February, Review.

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells
Soon Heng Tan C, Diam Go K, Bisteau X, Dai L, Han Yong C, Prabhu N, Burak Ozturk M, Ting Lim Y,  Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P
Science (2018) Online 8 February. Report.

Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden
Persson M, Razaz N, Tedroff K, Joseph KS, Cnattingius S
BMJ (2018) Online 8 February. Research.
On KI News: Apgar scores in neonates predict risk of CP and epilepsy

Kynurenic acid and GPR35 regulate adipose tissue energy homeostasis and inflammation
Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL.
Cell Metabolism (2018) Online 6 February. Article.
On KI News: How exercise training promotes a sound mind in a sound body

In vivo labeling by CD73 marks multipotent stromal cells and hightlights endothelial heterogeneity in the bone marrow niche
Breitbach M, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SE, Fleischmann BK.
Cell Stem Cell (2018) Online 1 February. Resource.

Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
Gut (2018) Online 30 January. Original Article.

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Khan AA, Paget JT, McLaughlin M et al.
Science Translational Medicine (2018) Online 24 January, Research Article.

Partnerships for child health: capitalising on links between the sustainable development goals
Blomstedt Y, Bhutta ZA, Dahlstrand  J, Friberg P,  Gostin LO, Nilsson M, Sewankambo NK, Tomson G, Alfvén T.
BMJ (2018) Online 23 January. Analysis.

Midbrain circuits that set locomotor speed and gait selection
Caggiano V, Leiras R, Goñi-Erro H, Masini D, Bellardita C, Bouvier J, Caldeira V, Fisone G, Kiehn O.
Nature (2018) Online 17 January. Article.
On KI News: “Start cells” in the midbrain control whether we walk or run

Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study
Hultcrantz M,  Björkholm M, MD, Dickman PW, Landgren O, Derolf ÅR, Kristinsson SY, Andersson TML
Annals of Internal Medicine (2018) Online 16 January. Original Research.

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob J-M, Cheng H-W, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, Hepworth MR, Huber S, Ludewig B, Peduto L, Villablanca EJ, Veiga-Fernandes H, Pereira JP, Flavell RA, Willinger T.
Immunity (2018) Online 16 January. Article.
On KI News: Oxysterols guide gut immune cells and are involved in inflammatory bowel disease

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing' has been scheduled
Hochgerner H, Zeisel A, Lönnerberg P, Linnarsson S
Nature Neuroscience (2018) 15 January. Resource.

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells
Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW
Nature (2018) Online 3 January. Letter.

An OPR 3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis
Chini A , Monte I , Zamarreño AM, Hamberg M, Lassueur S, Reymond P , Weiss S, Stintzi A, Schaller A,  Porzel A, García-Mina JM,  Solano R.
Nature Chemical Biology(2018) Online 1 January, Article.

Multi-trait analysis of genome-wide association summary statistics using
Turley P, Walters RK,  Maghzian O et al.
Nature Genetics (2018) Online 1 January, Article.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Demenais F, Margaritte-Jeannin P,  Barnes KC et al.
Nature Genetics (2017) Online 22 December. Article.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation
Marty FM, Ljungman P, Chemaly RF et al.
NEJM (2017) Online 21 December. Original Article.

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Thion MS, Low D, Silvin A et al.
Cell (2017) Online 21 December. Article.

Prostate Cancer Death After Radiotherapy or Radical Prostatectomy: A Nationwide Population-based Observational Study
Robinson D, Garmo H, Lissbrant IF, Widmark A, Pettersson A, Gunnlaugsson A, Adolfsson J, Bratt O, Nilsson P, Stattin P
European Urology (2017) Online 15 December. Article in Press.

Our Gut Microbiome: The Evolving Inner Self
Kundu P, Blacher E, Elinav E, Pettersson S
Cell (2017) Online 14 December. Review.

Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital MalformationsA Cohort Study From the International Pregnancy Safety Study Consortium
Huybrechts KF, Bröms G, Brix Christensen L et al
JAMA Psychiatry (2017) Online 13 December. Original Investigation.

Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
The Lancet Oncology (2017) Online 11 December. Article.
Comment: Neoadjuvant chemotherapy in breast cancer: more than just downsizing

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; for the CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project.
BMJ (2017) Online 7 December. Research.
On KI News: Genes behind higher education linked to lower risk of Alzheimer’s

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott Z, Mistrik M, Kaae Andersen K et al.
Nature (2017) Online 6 December. Article.
On KI News: Alcohol-abuse drug Antabuse kills cancer cells

An interactive framework for whole-brain maps at cellular resolution
Fürth D, Vaissière T, Tzortzi O, Xuan Y, Märtin A, Lazaridis I, Spigolon G, Fisone G, Tomer R, Deisseroth K, Carlén M, Miller CA, Rumbaugh G, Meletis K
Nature Neuroscience (2017) Online 4 December. Technical Report.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ et al
JAMA Psychiatry (2017) Online 29 November. Original Investigation

Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia
Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, Akarca A, Marafioti T, Quezada SA, Sarwar N, Seckl MJ
The Lancet (2017) Online 25 November. Article.

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A, Tyrakis PA, Macias D, Velica P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer Cell (2017) Online 13 November. Article.
On KI News: Harder for T cells to fight cancer in absence of VEGF-A

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes. DF
NEJM (2017) Online 9 November. Original Article
On KI News: Breast cancer recurrence risk lingers longer than expected

Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial
Price D, Buhl R, Chan A, Freeman D et al.
The Lancet Respiratory Medicine (2017) Online 3 November. Article in press.

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, Ekbom A, Neovius M, Ludvigsson JF, Askling J, Olén O
Gastroenterology (2017) Online 1 November. Article in Press.
On KI News: Older people with bowel disease receive older medicines

Information for KI researchers

If you cannot find your latest high impact publication in the list above, please contact the Communications Office. To be added to the list, the paper must have at least one KI affiliated author, and present original findings or a full review/oversight of a topic. The paper must also be recently published in a journal with JIF 15 or above, not more than a few months back in time. 

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