High impact publications

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Each year, researchers at Karolinska Institutet publish approx. 4,700 papers with original results in peer-reviewed scientific journals. Here we list the most recent publications with one or several authors from KI in high impact journals (JIF 15 and above). 

A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck M, He L, Andaloussi Mäe M, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T,  Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C
Nature (2018) Online 14 February. Article.
On KI News: Atlas of brain blood vessels provides fresh clues to brain diseases

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford WC, Peng X, Hägg Olofsson M, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Martinsson Ahlzén HS, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ
Science Translational Medicine (2018) Online 14 February, Research Article.
On KI News:  Possible new principle for cancer therapy

Outcome measures in coeliac disease trials: the Tampere recommendations
Ludvigsson JF, Ciacci C, Green PH et al
Gut (2018) Online 13 February. Original Article.

Toward an optically controlled brain
Feliu N, Neher E, Parak WJ
Science (2018) Online 9 February. Perspective.

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells
Soon Heng Tan C, Diam Go K, Bisteau X, Dai L, Han Yong C, Prabhu N, Burak Ozturk M, Ting Lim Y,  Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P
Science (2018) Online 8 February. Report.

Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden
Persson M, Razaz N, Tedroff K, Joseph KS, Cnattingius S
BMJ (2018) Online 8 February. Research.
On KI News: Apgar scores in neonates predict risk of CP and epilepsy

Kynurenic acid and GPR35 regulate adipose tissue energy homeostasis and inflammation
Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL.
Cell Metabolism (2018) Online 6 February. Article.
On KI News: How exercise training promotes a sound mind in a sound body

Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
Gut (2018) Online 30 January. Original Article.

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Khan AA, Paget JT, McLaughlin M et al.
Science Translational Medicine (2018) Online 24 January, Research Article.

Partnerships for child health: capitalising on links between the sustainable development goals
Blomstedt Y, Bhutta ZA, Dahlstrand  J, Friberg P,  Gostin LO, Nilsson M, Sewankambo NK, Tomson G, Alfvén T.
BMJ (2018) Online 23 January. Analysis.

Midbrain circuits that set locomotor speed and gait selection
Caggiano V, Leiras R, Goñi-Erro H, Masini D, Bellardita C, Bouvier J, Caldeira V, Fisone G, Kiehn O.
Nature (2018) Online 17 January. Article.
On KI News: “Start cells” in the midbrain control whether we walk or run

Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study
Hultcrantz M,  Björkholm M, MD, Dickman PW, Landgren O, Derolf ÅR, Kristinsson SY, Andersson TML
Annals of Internal Medicine (2018) Online 16 January. Original Research.

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob J-M, Cheng H-W, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, Hepworth MR, Huber S, Ludewig B, Peduto L, Villablanca EJ, Veiga-Fernandes H, Pereira JP, Flavell RA, Willinger T.
Immunity (2018) Online 16 January. Article.
On KI News: Oxysterols guide gut immune cells and are involved in inflammatory bowel disease

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing' has been scheduled
Hochgerner H, Zeisel A, Lönnerberg P, Linnarsson S
Nature Neuroscience (2018) 15 January. Resource.

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells
Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW
Nature (2018) Online 3 January. Letter.

An OPR 3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis
Chini A , Monte I , Zamarreño AM, Hamberg M, Lassueur S, Reymond P , Weiss S, Stintzi A, Schaller A,  Porzel A, García-Mina JM,  Solano R.
Nature Chemical Biology(2018) Online 1 January, Article.

Multi-trait analysis of genome-wide association summary statistics using
Turley P, Walters RK,  Maghzian O et al.
Nature Genetics (2018) Online 1 January, Article.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Demenais F, Margaritte-Jeannin P,  Barnes KC et al.
Nature Genetics (2017) Online 22 December. Article.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation
Marty FM, Ljungman P, Chemaly RF et al.
NEJM (2017) Online 21 December. Original Article.

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Thion MS, Low D, Silvin A et al.
Cell (2017) Online 21 December. Article.

Prostate Cancer Death After Radiotherapy or Radical Prostatectomy: A Nationwide Population-based Observational Study
Robinson D, Garmo H, Lissbrant IF, Widmark A, Pettersson A, Gunnlaugsson A, Adolfsson J, Bratt O, Nilsson P, Stattin P
European Urology (2017) Online 15 December. Article in Press.

Our Gut Microbiome: The Evolving Inner Self
Kundu P, Blacher E, Elinav E, Pettersson S
Cell (2017) Online 14 December. Review.

Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital MalformationsA Cohort Study From the International Pregnancy Safety Study Consortium
Huybrechts KF, Bröms G, Brix Christensen L et al
JAMA Psychiatry (2017) Online 13 December. Original Investigation.

Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
The Lancet Oncology (2017) Online 11 December. Article.
Comment: Neoadjuvant chemotherapy in breast cancer: more than just downsizing

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; for the CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project.
BMJ (2017) Online 7 December. Research.
On KI News: Genes behind higher education linked to lower risk of Alzheimer’s

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott Z, Mistrik M, Kaae Andersen K et al.
Nature (2017) Online 6 December. Article.
On KI News: Alcohol-abuse drug Antabuse kills cancer cells

An interactive framework for whole-brain maps at cellular resolution
Fürth D, Vaissière T, Tzortzi O, Xuan Y, Märtin A, Lazaridis I, Spigolon G, Fisone G, Tomer R, Deisseroth K, Carlén M, Miller CA, Rumbaugh G, Meletis K
Nature Neuroscience (2017) Online 4 December. Technical Report.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ et al
JAMA Psychiatry (2017) Online 29 November. Original Investigation

Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia
Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, Akarca A, Marafioti T, Quezada SA, Sarwar N, Seckl MJ
The Lancet (2017) Online 25 November. Article.

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A, Tyrakis PA, Macias D, Velica P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer Cell (2017) Online 13 November. Article.
On KI News: Harder for T cells to fight cancer in absence of VEGF-A

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes. DF
NEJM (2017) Online 9 November. Original Article
On KI News: Breast cancer recurrence risk lingers longer than expected

Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial
Price D, Buhl R, Chan A, Freeman D et al.
The Lancet Respiratory Medicine (2017) Online 3 November. Article in press.

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, Ekbom A, Neovius M, Ludvigsson JF, Askling J, Olén O
Gastroenterology (2017) Online 1 November. Article in Press.
On KI News: Older people with bowel disease receive older medicines

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
Soininen H, Solomon A, Jelle Visser P, Hendrix SB, Blennow K, Kivipelto M, Hartmann T on behalf of the LipiDiDiet clinical study group.
Lancet Neurology (2017) Online 30 October. Article.

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Ferreira MA, Vonk JM, Baurecht H et al.
Nature Genetics (2017) Online 30 October. Letter.
On KI News: Asthma, hay fever and eczema share more than 100 genetic risk factors

What constitutes the prefrontal cortex?
Marie Carlén
Science (2017) online 27 October. Review.

Prevalence of cerebral palsy in Uganda: a population-based study
Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H
Lancet Global Health (2017) Online 25 October. Article
On KI News: Cerebral palsy survey in Uganda fills knowledge gap

Less dementia with oral anticoagulation in atrial fibrillation
Friberg L, Rosenqvist M
European Heart Journal (2017) Online 25 October. Article.
On KI News: Blood-thinning drugs linked to decreased dementia risk in patients with atrial fibrillation

Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain
Roos A, Bandstein N, Lundbäck M, Hammarsten O, Ljung R, Holzmann MJ
JACC (2017) Online 23 October. Article.

Deciphering lipid structures based on platform-independent decision rules
Hartler J, Triebl A, Ziegl A et al
Nature Methods (2017) Online 23 October. Brief Communication.

Blood Transfusions From Previously Pregnant Women and MortalityInterpreting the Evidence
Cable RG, Edgren G
JAMA (2017) Online 17 October. Editorial.

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundström E, Pachnis V, Marklund U
Gaestroentology (2017) Online 11 October. Article in Press

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li Z, Chen J, Yu H et al
Nature Genetics (2017) Online 9 Otctober. Article.

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
Lein E, Borm LE, Linnarsson S
Science (2017) Online 6 October. Review.

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
Eikelboom JW, Connolly SJ, Bosch J et al.
NEJM (2017) Online 5 October. Original Article.

Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study
Chen DY,  See LC,  Liu JR,  Chuang CK, Pang ST, Hsieh IC, Wen MS, Chen TH, Lin YC, Liaw CC, Hsu CL, Chang JWC, Kuo CF, Huang  WK
JCO (2017) Online 2 October. Original Report.

The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA (2017) Online 26 September. Research Letter.

Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
Erlinge D, Omerovic E, Fröbert O et al.
NEJM (2017) Online 21 September. Original Article.

Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
Olén O, Askling J, Sachs MC, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF
BMJ (2017) Online 20 September. Research.
On KI News: Inflammatory bowel disease in childhood associated with increased risk of cancer

Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren MSjöstrand C, Roine RO, Hildick-Smith D, Spence JD,  Thomassen L, the Gore REDUCE Clinical Study Investigators
NEJM (2017) Online 14 September. Original Article. 

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
Holman RR, Coleman RL, Chan JCN et al
Lancet Diabetes & Endocrinology (2017) Online 13 September. Article.

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK.
Immunity (2017) Online 12 September. Article.

Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux
Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J
JAMA (2017) Online 12 September. Original Investigation.
On KI News: Relapse rare in young men after antireflux surgery

Information for KI researchers

Can’t find your article in the high impact publications list above? Please contact the Communications and Public Relations Office so that we can add your article to the list. Current list criterias are that article author-lists include at least one researcher from KI, and that articles – original findings or reviews – are published in journals with JIF 15 or above. 

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