CfA seminar: M2 macrophages in asthma: is their role regulated by chitinase-like proteins?
Speaker: Dr. Rafael de Quieroz Prado, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
About the speaker:
Dr. Rafael Prado was born in Brazil. He graduated as biologist and obtained both his master’s and PhD in Basic and Applied Immunology in the Department of Medicine at University of São Paulo.
His dissertation research was performed in the laboratory of Dr. Vania Bonato. He studied how toll-like receptor ligands modulate asthmatic parameters in animal models. As a detailed extension of Strachan hygiene hypothesis, his work contributed to the field by demonstrating that the attenuation of asthma by mycobacterial protein combined with unmethylated DNA requires a circuit involving TLR9, IFN-gamma, and bone-marrow-derived monocytes. In parallel, he also performed studies with experimental tuberculosis, where he investigated the impact of lung type-2 immunity induced by allergen sensitization over the mycobacterial infection.
Fascinated by the hypothesis that Th2 immunity can mediate tissue repair responses following damage, but not in allergic diseases, he moved to Washington, DC in Winter 2014 where he is currently a postdoctoral fellow in Dr. Thomas Wynn’s lab at National Institute of Allergy and Infectious Diseases, NIH. His postdoctoral research involves investigating the role of monocyte and macrophage subsets in wound healing, chronic inflammation, and fibrosis progression and resolution.
Dr. Prado has served as scientific referee for Ebiomedicine Journal and Brazilian Journal of Medical and Biological Research. Lately, he has also received several awards, including NIH Fellows Award for Research Excellence, Keystone Symposia Future of Science Fund Scholarship, and NIH Summer Research Mentor Award.