Xiaoqun Zhang

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About me

* 2008, Chinese Government Award for Outstanding Self-financed Student Abroad * FENS award to young scientists, Barcelona, Spain, 2012. 2003: Medical Degree, China Medical University, Shenyang, China. 2008: Ph.D in Medical Science and in the field of Neuropharmacology, Karolinska Institutet

Research

The main focus of my research is to study the function of some GPCRs that are mainly affected in PD and the progressive loss of nigrostriatal dopaminergic neurons in PD can be influenced by therapeutic approaches that target those GPCRs. A battery of complementary techniques which include brain slice electrophysiology and electrochemistry, pharmacology, biochemistry, histochemistry and behavioral testing in different genetic and toxic animal models for PD have been used to address all the issues raised in the projects.

Articles

Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2023;34(5):836-846

On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging.

Kaya I; Schembri LS; Nilsson A; Shariatgorji R; Baijnath S; Zhang X; Bezard E; Svenningsson P; Odell LR; Andrén PE
Article: NPJ PARKINSONS DISEASE. 2023;9(1):56

Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice.

Skiteva O; Yao N; Mantas I; Zhang X; Perlmann T; Svenningsson P; Chergui K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(22):14290

Impaired Aversive Memory Formation in GPR37L1KO Mice.

Veenit V; Zhang X; Paslawski W; Mantas I; Svenningsson P
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2022;72(11):2313-2325

Prosaposin Reduces α-Synuclein in Cells and Saposin C Dislodges it from Glucosylceramide-enriched Lipid Membranes.

Kojima R; Zurbruegg M; Li T; Paslawski W; Zhang X; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):12056

Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology.

He Y; Zhang X; Flais I; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;23(1):410

The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.

Veenit V; Zhang X; Ambrosini A; Sousa V; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(16):8907

Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants.

Mantas I; Millan MJ; Di Cara B; Groenink L; Veiga S; Cistarelli L; Brocco M; Bertrand M; Svenningsson P; Zhang X
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2021;60(33):18022-18030

Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology.

Kampen S; Duy Vo D; Zhang X; Panel N; Yang Y; Jaiteh M; Matricon P; Svenningsson P; Brea J; Loza MI; Kihlberg J; Carlsson J
Article: BIOLOGICAL PSYCHIATRY. 2021;90(1):16-27

TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.

Mantas I; Vallianatou T; Yang Y; Shariatgorji M; Kalomoiri M; Fridjonsdottir E; Millan MJ; Zhang X; Andrén PE; Svenningsson P
Article: NEUROPHARMACOLOGY. 2020;174:108136

NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism.

Sitzia G; Mantas I; Zhang X; Svenningsson P; Chergui K
Article: NEUROBIOLOGY OF DISEASE. 2020;137:104738

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.

Hulme H; Fridjonsdottir E; Gunnarsdottir H; Vallianatou T; Zhang X; Wadensten H; Shariatgorji R; Nilsson A; Bezard E; Svenningsson P; Andrén PE
Article: NEUROPHARMACOLOGY. 2020;162:107829

Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.

Mantas I; Yang Y; Mannoury-la-Cour C; Millan MJ; Zhang X; Svenningsson P
Article: FRONTIERS IN AGING NEUROSCIENCE. 2020;12:84

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37.

Zhang X; Mantas I; Fridjonsdottir E; Andrén PE; Chergui K; Svenningsson P
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:304

Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses.

Schintu N; Zhang X; Stroth N; Mathé AA; Andrén PE; Svenningsson P
Article: NATURE METHODS. 2019;16(10):1021-1028

Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging.

Shariatgorji M; Nilsson A; Fridjonsdottir E; Vallianatou T; Källback P; Katan L; Sävmarker J; Mantas I; Zhang X; Bezard E; Svenningsson P; Odell LR; Andrén PE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(30):15226-15235

α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.

Paslawski W; Zareba-Paslawska J; Zhang X; Hölzl K; Wadensten H; Shariatgorji M; Janelidze S; Hansson O; Forsgren L; Andrén PE; Svenningsson P
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2066-2077

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.

Yao N; Skiteva O; Zhang X; Svenningsson P; Chergui K
Article: CNS NEUROSCIENCE & THERAPEUTICS. 2018;24(2):144-153

CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.

Nouhi M; Zhang X; Yao N; Chergui K
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:166

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.

Zhang X; Mantas I; Alvarsson A; Yoshitake T; Shariatgorji M; Pereira M; Nilsson A; Kehr J; Andrén PE; Millan MJ; Chergui K; Svenningsson P
Article: EXPERIMENTAL NEUROLOGY. 2017;292:11-20

Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism.

Monnot C; Zhang X; Nikkhou-Aski S; Damberg P; Svenningsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(10):2735-2740

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Green H; Zhang X; Tiklova K; Volakakis N; Brodin L; Berg L; Greengard P; Perlmann T; Svenningsson P
Article: LEARNING & MEMORY. 2016;23(9):479-485

The GABAA receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum.

Zhang X; Yao N; Chergui K
Article: NEUROIMAGE. 2016;136:129-138

Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry.

Shariatgorji M; Strittmatter N; Nilsson A; Källback P; Alvarsson A; Zhang X; Vallianatou T; Svenningsson P; Goodwin RJA; Andren PE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(5):1423-1428

Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.

Marongiu R; Arango-Lievano M; Francardo V; Morgenstern P; Zhang X; Cenci MA; Svenningsson P; Greengard P; Kaplitt MG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(5):1429-1434

p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.

Schintu N; Zhang X; Alvarsson A; Marongiu R; Kaplitt MG; Greengard P; Svenningsson P
Article: NEUROSCIENCE LETTERS. 2016;611:51-58

Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity.

Yang J; Hertz E; Zhang X; Leinartaité L; Lundius EG; Li J; Svenningsson P
Article: JOURNAL OF NEUROSCIENCE. 2015;35(41):14057-14069

Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.

Alvarsson A; Zhang X; Stan TL; Schintu N; Kadkhodaei B; Millan MJ; Perlmann T; Svenningsson P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(10):1714-1722

Lurasidone and fluoxetine reduce novelty-induced hypophagia and NMDA receptor subunit and PSD-95 expression in mouse brain.

Stan TL; Sousa VC; Zhang X; Ono M; Svenningsson P
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2015;26(6):934-939

Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines.

Shariatgorji M; Nilsson A; Källback P; Karlsson O; Zhang X; Svenningsson P; Andren PE
Article: NEUROPHARMACOLOGY. 2015;92:108-115

Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors.

Zhang X; Chergui K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(4):pyu052

Induction of cannabinoid- and N-methyl-D-aspartate receptor-mediated long-term depression in the nucleus accumbens and dorsolateral striatum is region and age dependent.

Zhang X; Feng Z-J; Chergui K
Article: NEURON. 2014;84(4):697-707

Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections.

Shariatgorji M; Nilsson A; Goodwin RJA; Källback P; Schintu N; Zhang X; Crossman AR; Bezard E; Svenningsson P; Andren PE
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2014;171(16):3938-3945

Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease.

Zhang X; Feng Z-J; Chergui K
Article: EXPERIMENTAL NEUROLOGY. 2014;255:154-160

Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease.

Feng Z-J; Zhang X; Chergui K
Article: JOURNAL OF NEUROCHEMISTRY. 2014;129(4):581-590

GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease.

Zhang X; Feng Z-J; Chergui K
Article: MOLECULAR PSYCHIATRY. 2013;18(10):1096-1105

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.

Eriksson TM; Alvarsson A; Stan TL; Zhang X; Hascup KN; Hascup ER; Kehr J; Gerhardt GA; Warner-Schmidt J; Arango-Lievano M; Kaplitt MG; Ogren SO; Greengard P; Svenningsson P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(4):919-924

Reduced phosphorylation of GluA1 subunits relates to anxiety-like behaviours in mice.

Kiselycznyk C; Zhang X; Huganir RL; Holmes A; Svenningsson P
Article: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36(12):2117-2125

Ethanol disrupts the mechanisms of induction of long-term potentiation in the mouse nucleus accumbens.

Mishra D; Zhang X; Chergui K
Article: JOURNAL OF NEUROCHEMISTRY. 2012;123(5):811-823

Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice.

Egeland M; Zhang X; Millan MJ; Mocaer E; Svenningsson P
Article: NEUROPHARMACOLOGY. 2012;62(1):347-357

Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects.

Nilsson A; Stroth N; Zhang X; Qi H; Fälth M; Sköld K; Hoyer D; Andrén PE; Svenningsson P
Article: NEUROCHEMISTRY INTERNATIONAL. 2011;59(8):1109-1122

Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.

Szegedi V; Juhász G; Zhang X; Barkóczi B; Qi H; Madeira A; Kapus G; Svenningsson P; Spedding M; Penke B
Article: PSYCHOPHARMACOLOGY. 2011;218(4):621-634

Antidepressant-like properties of sarizotan in experimental Parkinsonism.

Zhang X; Egeland M; Svenningsson P
Article: NEUROCHEMISTRY INTERNATIONAL. 2011;59(2):280-289

Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression.

Madeira A; Yang J; Zhang X; Vikeved E; Nilsson A; Andrén PE; Svenningsson P
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2011;519(9):1815-1827

Distribution, level, pharmacology, regulation, and signaling of 5-HT6 receptors in rats and marmosets with special reference to an experimental model of parkinsonism.

Zhang X; Andren PE; Glennon RA; Svenningsson P
Article: BIOLOGICAL PSYCHIATRY. 2010;68(6):528-535

A role for p11 in the antidepressant action of brain-derived neurotrophic factor.

Warner-Schmidt JL; Chen EY; Zhang X; Marshall JJ; Morozov A; Svenningsson P; Greengard P
Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(5):1094-1104

Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease.

Nilsson A; Fälth M; Zhang X; Kultima K; Sköld K; Svenningsson P; Andrén PE
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(2):201-215

S100B overexpressing mutant mice exhibit prolonged behavioural and biochemical responses towards repeated intermittent binge treatments with MDMA.

Kindlundh-Högberg AMS; Zhang X; Svenningsson P
Article: NEUROPHARMACOLOGY. 2009;56(1):37-46

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation.

Qi H; Mailliet F; Spedding M; Rocher C; Zhang X; Delagrange P; McEwen B; Jay TM; Svenningsson P
Article: NEUROPHARMACOLOGY. 2008;54(7):1143-1152

Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.

Zhang X; Andren PE; Chergui K; Svenningsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(6):2163-2168

Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism.

Zhang X; Andren PE; Greengard P; Svenningsson P
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(10):3952-3961

Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.

Nilsson A; Sköld K; Sjögren B; Svensson M; Pierson J; Zhang X; Caprioli RM; Buijs J; Persson B; Svenningsson P; Andrén PE
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):29-33

Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson's disease model.

Zhang X; Andren PE; Svenningsson P
Article: BRAIN RESEARCH. 2006;1095(1):207-210

Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease.

Zhang X; Andren PE; Svenningsson P
Article: JOURNAL OF PROTEOME RESEARCH. 2006;5(2):262-269

Decreased striatal levels of PEP-19 following MPTP lesion in the mouse.

Sköld K; Svensson M; Nilsson A; Zhang X; Nydahl K; Caprioli RM; Svenningsson P; Andrén PE
Article: SCIENCE. 2006;311(5757):77-80

Alterations in 5-HT1B receptor function by p11 in depression-like states.

Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang X; El Yacoubi M; Vaugeois J-M; Nomikos GG; Greengard P
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All other publications

Letter: MOVEMENT DISORDERS. 2021;36(5):1278-1280

Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.

Paslawski W; Bergström S; Zhang X; Remnestål J; He Y; Boxer A; Månberg A; Nilsson P; Svenningsson P
Published paper: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2020;31(12):2553-2557

Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds.

Shariatgorji R; Nilsson A; Strittmatter N; Vallianatou T; Zhang X; Svenningsson P; Goodwin RJA; Andrén PE
Review: JOURNAL OF PARKINSONS DISEASE. 2012;2(2):87-106

Studies of depression-related states in animal models of Parkinsonism.

Schintu N; Zhang X; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S14-S15

GluN2D-containing NMDA receptors in cholinergic interneurons control dopamine release in the mouse striatum

Zhang X; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S181

Sarizotan stimulates cell proliferation in neurogenic regions in experimental Parkinsonism

Egeland M; Zhang X; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S9-S10

Sarizotan stimulates cell proliferation in neurogenic regions in experimental Parkinsonism

Egeland M; Zhang X; Svenningsson P

Employments

Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2020-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2008

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