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Publications

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2)
Frykman S, Inoue M, Ikeda A, Teranishi Y, Kihara T, Lundgren Jl, et al
Biochemical and biophysical research communications 2017;483(1):352-358

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
Schedin-weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto Ng, Wiehager B, et al
Alzheimer's research & therapy 2017;9(1):57-

ADAM10 and BACE1 are localized to synaptic vesicles
Lundgren Jl, Ahmed S, Schedin-weiss S, Gouras Gk, Winblad B, Tjernberg Lo, et al
Journal of neurochemistry 2015;135(3):606-15

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage
Teranishi Y, Inoue M, Yamamoto Ng, Kihara T, Wiehager B, Ishikawa T, et al
The FEBS journal 2015;282(17):3438-51

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals
Lundgren Jl, Ahmed S, Winblad B, Gouras Gk, Tjernberg Lo, Frykman S
Neuroscience letters 2014;566():125-30

Erlin-2 is associated with active gamma-secretase in brain and affects amyloid beta-peptide production
Teranishi Y, Hur Jy, Gu Gj, Kihara T, Ishikawa T, Nishimura T, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2012;424(3):476-81

Identification of Novel gamma-Secretase-associated Proteins in Detergent-resistant Membranes from Brain
Hur Jy, Teranishi Y, Kihara T, Yamamoto Ng, Inoue M, Hosia W, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(15):11991-2005

Identification of two novel synaptic gamma-secretase associated proteins that affect amyloid beta-peptide levels without altering Notch processing
Frykman S, Teranishi Y, Hur Jy, Sandebring A, Yamamoto Ng, Ankarcrona M, et al
NEUROCHEMISTRY INTERNATIONAL 2012;61(1):108-18

Minor contribution of presenilin 2 for gamma -secretase activity in mouse embryonic fibroblasts and adult mouse brain
Franberg J, Svensson Ai, Winblad B, Karlstrom H, Frykman S
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2011;404(1):564-8

Mitochondrial gamma-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
Pavlov Pf, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, et al
FASEB JOURNAL 2011;25(1):78-88

Affinity pulldown of gamma-secretase and associated proteins from human and rat brain
Teranishi Y, Hur Jy, Welander H, Franberg J, Aoki M, Winblad B, et al
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2010;14(11):2675-86

gamma-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes
Franberg J, Karlstrom H, Winblad B, Tjernberg Lo, Frykman S
PLOS ONE 2010;5(3):e9772-

Synaptic and Endosomal Localization of Active gamma-Secretase in Rat Brain
Frykman S, Hur Jy, Franberg J, Aoki M, Winblad B, Nahalkova J, et al
PLOS ONE 2010;5(1):e8948-

Active gamma-secretase is localized to detergent-resistant membranes in human brain
Hur Jy, Welander H, Behbahani H, Aoki M, Franberg J, Winblad B, et al
FEBS JOURNAL 2008;275(6):1174-87

Rat brain gamma-secretase activity is highly influenced by detergents
Franberg J, Welander H, Aoki M, Winblad B, Tjernberg Lo, Frykman S
BIOCHEMISTRY 2007;46(25):7647-54

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
Hansson Ca, Frykman S, Farmery Mr, Tjernberg Lo, Nilsberth C, Pursglove Se, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(49):51654-60

Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons
Hamner S, Arumae U, Li-ying Y, Sun Yf, Saarma M, Lindholm D
MOLECULAR AND CELLULAR NEUROSCIENCE 2001;17(1):97-106

Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system
Hamner S, Skoglosa Y, Lindholm D
NEUROSCIENCE 1999;91(2):673-84

Bcl-2 regulates the levels of the cysteine proteases ICH and CPP32/Yama in human neuronal precursor cells
Korhonen L, Hamner S, Olsson Pa, Lindholm D
EUROPEAN JOURNAL OF NEUROSCIENCE 1997;9(11):2489-96

Neurotrophins and cerebellar development
Lindholm D, Hamner S, Zirrgiebel U
PERSPECTIVES ON DEVELOPMENTAL NEUROBIOLOGY 1997;5(1):83-94

Cell density increases Bcl-2 and Bcl-x expression in addition to survival of cultured cerebellar granule neurons
Ohga Y, Zirrgiebel U, Hamner S, Michaelidis Tm, Cooper J, Thoenen H, et al
NEUROSCIENCE 1996;73(4):913-7

Cell Density up-regulates BCL-2 and BCL-X expression in cultured cerebellar granule neurons and increases survival: Implication for action of neurotrophic factors
Lindholm D, Zirrgiebel U, Hamner S, Michaelidis T, Cooper J, Thoenen H, et al
JOURNAL OF BRAIN RESEARCH-JOURNAL FUR HIRNFORSCHUNG 1996;37(4):598-599

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