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About me

Postdoctoral Research Fellow

Education

2013 - PhD in Biochemistry, Genome Damage & Stability Centre, University of Sussex, UK

2008 - BSc (Hons) in Biochemistry, University of Manchester, UK

Research description

 

My research centres upon the interplay between DNA precursor metabolism and genome stability, and how this can be exploited to enhance existing cancer therapies. Currently, my research is focused upon the enzyme SAMHD1, which we identified as a barrier to the efficacy of several antimetabolite-based cancer therapies.

 

For further reading see selected publications:

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.

SAMHD1 is a barrier to antimetabolite-based cancer therapies.

Pathways controlling dNTP pools to maintain genome stability.

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.

Teaching portfolio

Main supervisor for MSc students

Co-supervisor for PhD student

Academic honours, awards and prizes

The Swedish Childhood Cancer Foundation Postdoctoral Fellowship

EMBO Long-Term Fellowship

 

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