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Education

Master of Science, The University of Michigan, Ann Arbor, MI, USA, 1983

Ph.D., The University of Michigan, Ann Arbor, MI, USA, 1985

Publications

Identification of novel GLI1 target genes and regulatory circuits in human cancer cells
Diao Y, Rahman Mf, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, et al
Molecular oncology 2018;12(10):1718-1734

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism
Azatyan A, Gallo-oller G, Diao Y, Selivanova G, Johnsen Ji, Zaphiropoulos Pg
Cancer letters 2018;442():341-350

Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells
Diao Ym, Azatyan A, Rahman Mfu, Zhao Cy, Zhu J, Dahlman-wright K, et al
ONCOTARGET 2016;7(44):71580-71593

Tamoxifen Resistance: Emerging Molecular Targets
Rondón-lagos M, Villegas Ve, Rangel N, Sánchez Mc, Zaphiropoulos Pg
International journal of molecular sciences 2016;17(8):-

Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling
Villegas Ve, Rondón-lagos M, Annaratone L, Castellano I, Grismaldo A, Sapino A, et al
International journal of molecular sciences 2016;17(3):308-

An updated h-index measures both the primary and total scientific output of a researcher
Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson Gl, Sumazin P, et al
Discoveries (Craiova, Romania) 2015;3(3):-

Neighboring gene regulation by antisense long non-coding RNAs
Villegas Ve, Zaphiropoulos Pg
International journal of molecular sciences 2015;16(2):3251-66

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1
Villegas Ve, Rahman Mf, Fernandez-barrena Mg, Diao Y, Liapi E, Sonkoly E, et al
Molecular oncology 2014;8(5):912-26

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
Diao Y, Rahman Mf, Villegas Ve, Wickström M, Johnsen Ji, Zaphiropoulos Pg
BMC cancer 2014;14():600-

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
Shimokawa T, Rahman Mfu, Tostar U, Sonkoly E, Stahle M, Pivarcsi A, et al
RNA BIOLOGY 2013;10(2):321-33

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg Om, et al
International journal of cancer 2013;132(7):1516-24

Genetic variations and alternative splicing: the Glioma associated oncogene 1, GLI1
Zaphiropoulos Pg
Frontiers in genetics 2012;3():119-

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, et al
Oncogenesis 2012;1():e3-

Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant
Tostar U, Finta C, Rahman Mfu, Shimokawa T, Zaphiropoulos Pg
PLOS ONE 2012;7(5):e37761-

COMBINED EFFECTS OF 5-AZA-2 ' DEOXYCYTIDINE AND 4-PHENYLBUTYRATE ON MEDULLOBLASTOMA
Marino Am, Johnsen Ji, Ekstrom Tj, Zaphiropoulos P, Ostman A
NEURO-ONCOLOGY 2011;:I9-I9

MiR-203 functions as a tumor suppressor microRNA in basal cell carcinoma
Sonkoly E, Loven J, Wei T, Xu N, Meisgen F, Brodin P, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2011;:S20-S20

PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas
Santos Dcc, Zaphiropoulos Pg, Neto Cf, Pimentel Era, Sanches Ja, Ruiz Irg
INTERNATIONAL JOURNAL OF DERMATOLOGY 2011;50(7):838-43

Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?
Zaphiropoulos Pg
Frontiers in genetics 2011;2():92-

Genetic variations regulate alternative splicing in the 5 ' untranslated regions of the mouse glioma-associated oncogene 1, Gli1
Palaniswamy R, Teglund S, Lauth M, Zaphiropoulos Pg, Shimokawa T
BMC MOLECULAR BIOLOGY 2010;:32-

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway
Tostar U, Toftgård R, Zaphiropoulos Pg, Shimokawa T
Genes & cancer 2010;1(9):941-51

Lack of aneuploidy for chromosomes 15, 16, and 18 in placentas from small-for-gestational-age liveborn infants
Papadogiannakis N, Iwarsson E, Taimi T, Zaphiropoulos Pg, Westgren M
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 2008;198(2):231.e1-7

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgard R, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2008;283(21):14345-54

Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling
Shimokawa T, Svard J, Heby-henricson K, Teglund S, Toftgard R, Zaphiropoulos Pg
ONCOGENE 2007;26(34):4889-96

Inhibition of GLI1 gene activation by patched1
Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, et al
BIOCHEMICAL JOURNAL 2006;:19-26

PTCH mutations: Distribution and analyses
Lindstrom E, Shimokawa T, Toftgard R, Zaphiropoulos Pg
HUMAN MUTATION 2006;27(3):215-9

A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions
Shimokawa T, Rahnama F, Zaphiropoulos Pg
FEBS LETTERS 2004;578(1-2):157-62

Distinct roles of PTCH2 splice variants in Hedgehog signalling
Rahnama F, Toftgard R, Zaphiropoulos Pg
BIOCHEMICAL JOURNAL 2004;:325-34

The FU gene and its possible protein isoforms
Osterlund T, Everman Db, Betz Rc, Mosca M, Nothen Mm, Schwartz Ce, et al
BMC GENOMICS 2004;:49-

A map of the mouse Cyp3a locus
Zaphiropoulos Pg
DNA SEQUENCE 2003;14(3):155-62

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
Kogerman P, Krause D, Rahnama F, Kogerman L, Unden Ab, Zaphiropoulos Pg, et al
ONCOGENE 2002;21(39):6007-16

Intergenic mRNA molecules resulting from trans-splicing
Finta C, Zaphiropoulos Pg
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(8):5882-90

Intergenic mRNAs. Minor gene products or tools of diversity?
Finta C, Warner Sc, Zaphiropoulos Pg
HISTOLOGY AND HISTOPATHOLOGY 2002;17(2):677-82

Template switching generated during reverse transcription?
Zaphiropoulos Pg
FEBS LETTERS 2002;527(1-3):326-

A statistical view of genome transcription?
Finta C, Zaphiropoulos Pg
JOURNAL OF MOLECULAR EVOLUTION 2001;53(2):160-2

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450
Domanski Tl, Finta C, Halpert Jr, Zaphiropoulos Pg
MOLECULAR PHARMACOLOGY 2001;59(2):386-92

Intergenic transcripts containing a novel human cytochrome P4502C exon 1 spliced to sequences from the CYP2C9 gene
Warner Sc, Finta C, Zaphiropoulos Pg
MOLECULAR BIOLOGY AND EVOLUTION 2001;18(10):1841-8

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
Nilsson M, Unden Ab, Krause D, Malmqwist U, Raza K, Zaphiropoulos Pg, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000;97(7):3438-43

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors
Jogi A, Abel F, Sjoberg Rm, Toftgard R, Zaphiropoulos Pg, Pahlman S, et al
INTERNATIONAL JOURNAL OF ONCOLOGY 2000;16(5):943-9

The human CYP2C locus: A prototype for intergenic and exon repetition splicing events
Finta C, Zaphiropoulos Pg
GENOMICS 2000;63(3):433-8

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons
Finta C, Zaphiropoulos Pg
GENE 2000;260(1-2):13-23

Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1
Kogerman P, Grimm T, Kogerman L, Krause D, Unden Ab, Sandstedt B, et al
NATURE CELL BIOLOGY 1999;1(5):312-9

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
Zaphiropoulos Pg, Unden Ab, Rahnama F, Hollingsworth Re, Toftgard R
CANCER RESEARCH 1999;59(4):787-92

RNA molecules containing exons originating from different members of the cytochrome P4502C gene subfamily (CYP2C) in human epidermis and liver
Zaphiropoulos Pg
NUCLEIC ACIDS RESEARCH 1999;27(13):2585-90

The kidney cytochrome P-4502C23 arachidonic acid epoxygenase is upregulated during dietary salt loading
Holla Vr, Makita K, Zaphiropoulos Pg, Capdevila Jh
JOURNAL OF CLINICAL INVESTIGATION 1999;104(6):751-60

Mechanisms of pre-mRNA splicing: Classical versus non-classical pathways
Zaphiropoulos Pg
HISTOLOGY AND HISTOPATHOLOGY 1998;13(2):585-9

Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin
Eklund Lk, Lindstrom E, Unden Ab, Lundh-rozell B, Stahle-backdahl M, Zaphiropoulos Pg, et al
MOLECULAR CARCINOGENESIS 1998;21(2):87-92

Non-homologous recombination mediated by Thermus aquaticus DNA polymerase I. Evidence supporting a copy choice mechanism
Zaphiropoulos Pg
NUCLEIC ACIDS RESEARCH 1998;26(12):2843-8

Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis
Zaphiropoulos Pg
MOLECULAR AND CELLULAR BIOLOGY 1997;17(6):2985-93

Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
Unden Ab, Zaphiropoulos Pg, Bruce K, Toftgard R, Stahlebackdahl M
CANCER RESEARCH 1997;57(12):2336-40

The gene for Gorlin's syndrome, human patched, is consistently overexpressed in both hereditary and sporadic basal cell carcinomas
Unden Ab, Bruce K, Zaphiropoulos Pg, Toftgard R, Stahlebackdahl M
JOURNAL OF INVESTIGATIVE DERMATOLOGY 1997;108(4):352-352

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Hahn H, Christiansen J, Wicking C, Zaphiropoulos Pg, Chidambaram A, Gerrard B, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(21):12125-8

cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region
Zaphiropoulos Pg, Toftgard R
DNA AND CELL BIOLOGY 1996;15(12):1049-56

Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping
Zaphiropoulos Pg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(13):6536-41

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PTCH inactivation
Unden Ab, Holmberg E, Lundhrozell B, Stahlebackdahl M, Zaphiropoulos Pg, Toftgard R, et al
CANCER RESEARCH 1996;56(20):4562-5

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
Hahn H, Wicking C, Zaphiropoulos Pg, Gailani Mr, Shanley S, Chidambaram A, et al
CELL 1996;85(6):841-51

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
Gailani Mr, Stahlebackdahl M, Leffell Dj, Glynn M, Zaphiropoulos Pg, Pressman C, et al
NATURE GENETICS 1996;14(1):78-81

CYTOCHROME-P450 GENES EXPRESSED IN PORCINE OVARIES - IDENTIFICATION OF NOVEL FORMS, EVIDENCE FOR GENE CONVERSION, AND EVOLUTIONARY RELATIONSHIPS
Zaphiropoulos Pg, Skantz A, Eliasson M, Ahlberg Mb
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1995;212(2):433-41

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