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Education

Currently Assistant Professor and Team Leader Translational Medicine, Department of Oncology-Pathology, Karolinska Institute

Visting Professor, 2017, Department of Science, Roma Tre University, Rome, Italy

Project Leader 2016-2018,  Department of Medical Biochemistry and Biophysics, Karolinska Institute

Team Leader Target Biology, 2015-2017, Department of Medical Biochemistry and Biophysics, Karolinska Institute

Post-doctoral training, 2014-2016, Department of Medical Biochemistry and Biophysics, Karolinska Institute

Post-doctoral training, 2012-2014, Department of Medicine Solna, Karolinska Institute

PhD in Medical Science, 2012 Department of Biosciences and Nutrition, Karolinska Institutet. Thesis title: “Modulation of Nuclear Receptor Signaling by RBR Ubiquitin Ligases”. 

MSc, 2008, Stockholm University

Research description

My research is focused on understanding how altered metabolism can regulate the capacity of cancer cells to repair their DNA and translate this into novel treatments for cancer patients.

Team Members:

Anna Huguet Ninou, doctoral student KI

Jemina Letho, doctoral student KI

Co-supervisor for following PhD students:

Nadilly Bonagas,  doctoral student KI

 

 

 

 

 

 

 

 

 

 

 

Academic honours, awards and prizes

2018, Medtech4Health/Vinnova/SWELife          

2017, Visting Professor, Department of Science, Roma Tre University, Rome, Italy

2016, 2017  The Felix Mindus contribution to leukemia research        

2015, Swedish Childhood Cancer Foundation (Barncancerfonden), Postdoctoral Fellowship                      

2013, Swedish Society for Medical Research, Postdoctoral Fellowship

Publications

Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation
Henriksson S, Groth P, Gustafsson N, Helleday T
Cell cycle (Georgetown, Tex.) 2018;17(5):568-579

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Gustafsson R, Jemth As, Gustafsson Nm, Färnegårdh K, Loseva O, Wiita E, et al
Cancer research 2017;77(4):937-948

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie Nc, Hagenkort A, Page Bd, Masuyer G, Rehling D, Carter M, et al
Cancer research 2016;76(18):5501-11

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
Gustafsson Sheppard N, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, et al
Scientific reports 2015;5():15029-

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
Nilsson R, Jain M, Madhusudhan N, Sheppard Ng, Strittmatter L, Kampf C, et al
Nature communications 2014;5():3128-

Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression
Gustafsson Sheppard N, Heldring N, Dahlman-wright K
Journal of molecular endocrinology 2012;49(3):277-87

Molecular characterization of estrogen receptor signaling in breast cancer cells
Zhao C, Gao H, Gustafsson N, Papoutsi Z, Jaffrey S, Gustafsson Ja, et al
FEBS JOURNAL 2010;:10-10

RBCK1 Drives Breast Cancer Cell Proliferation by Promoting Transcription of Estrogen Receptor alpha and Cyclin B1
Gustafsson N, Zhao Cy, Gustafsson Ja, Dahlman-wright K
CANCER RESEARCH 2010;70(3):1265-74

E3 Ubiquitin Ligase RNF31 Cooperates with DAX-1 in Transcriptional Repression of Steroidogenesis
Ehrlund A, Anthonisen Eh, Gustafsson N, Venteclef N, Remen Kr, Damdimopoulos Ae, et al
MOLECULAR AND CELLULAR BIOLOGY 2009;29(8):2230-42

Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice (vol 102, pg 3857, 2005)
Andersson S, Gustafsson N, Warner M, Gustafsson Ja
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006;103(21):8298-8298

Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice
Andersson S, Gustafsson N, Warner M, Gustafsson Ja
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005;102(10):3857-62

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