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About me

I am since November 2018 working as a Postdoctoral fellow in Professor Agneta Nordberg’s group. My main area of research is the in vitro characterization of novel PET tracers against neuroinflammation in Alzheimer’s disease, specifically astrocytosis, using radioligand binding assay and autoradiography. I defended my PhD in Neurochemistry with Molecular neurobiology from the Department of Biochemistry and Biophysics at Stockholm University in February 2018. I was supervised by late Professor Kerstin Iverfeldt, followed by Associate Professor Anna-Lena Ström. The focus of my thesis was the characterization of the interaction between the Alzheimer’s disease associated Amyloid-β Precursor Protein (APP) and one of its adaptor proteins Fe65. More specifically, the effect of posttranslational modifications (PTMs), such as phosphorylation, on the APP/Fe65 interaction and their nuclear localization, in addition to how PTMs affect the processing of APP.

Research description

We try to understand the binding properties of a tentative astrocytic PET tracer in human postmortem brain tissue from cognitively normal (control) and AD patients, using autoradiography and binding assay techniques. We are also interested in comparing the binding properties of this novel tracer with an astrocytic PET tracer already in clinical use, and to investigate the relationships between astrocytosis and Aβ- or tau depositions.

Publications

Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
Koistinen Na, Edlund Ak, Menon Pk, Ivanova Ev, Bacanu S, Iverfeldt K
PloS one 2017;12(3):e0173888-

Phosphorylation of Fe65 amyloid precursor protein-binding protein in response to neuronal differentiation
Koistinen Na, Bacanu S, Iverfeldt K
Neuroscience letters 2016;613():54-9