Milena Zeitelhofer Adzemovic

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About me

Associate professor in Neuroscience.
Consultant in Neurology and Psychiatry.
Leader of the research team conducting basic- and translational research focusing on neuropathology of autoimmune neuroinflammation.

Research

Clinical evaluation and epidemiological investigation of mental health in chronic autoimmune conditions, with particular focus on MS.

Neuropathology of autoimmune neuroinflammation including multiple sclerosis (MS) and peripheral neuropathies.

Teaching

Teaching experience at all levels of the three cycle-education as well as post-doctoral:

- teaching in the study programme at KI (Medicine and Biomedicine)
- lecturing at obligatory and elective courses (study programme
doctoral education
clinical residency)
- clinical and laboratory supervision
mentorship
- supervision of degree projects at the undergraduate and graduate level
- organization of the doctoral course “Clinical and Experimental Neuroimmunology”

Articles

Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(175)

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines.

Üçal M; Haindl MT; Adzemovic MZ; Zeitelhofer M; Schaefer U; Fazekas F; Hochmeister S
Article: JOURNAL OF NEUROINFLAMMATION. 2021;18(1):138

Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination.

Haindl MT; Üçal M; Klaus B; Tögl L; Dohrmann J; Adzemovic MZ; Enzinger C; Hochmeister S
Article: SCIENTIFIC REPORTS. 2020;10(1):22383

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier.

Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077

Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.

Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.

N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
Article: FRONTIERS IN NEUROLOGY. 2020;11:600401

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta).

Hochmeister S; Aeinehband S; Dorris C; Berglund R; Haindl MT; Velikic V; Gustafsson SA; Olsson T; Piehl F; Jagodic M; Zeitelhofer M; Adzemovic MZ
Article: CLINICAL EPIGENETICS. 2019;11(1):86

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.

Kular L; Needhamsen M; Adzemovic MZ; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegnér J; Beck S; Piehl F; Brundin L; Jagodic M
Article: GLIA. 2019;67(3):467-481

The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis.

Haindl MT; Köck U; Zeitelhofer-Adzemovic M; Fazekas F; Hochmeister S
Article: PLOS ONE. 2018;13(7):e0200649

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CChum mice.

Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
Article: EXPERIMENTAL NEUROLOGY. 2017;294:32-44

Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats.

Üçal M; Haindl MT; Adzemovic MZ; Strasser J; Theisl L; Zeitelhofer M; Kraitsy K; Ropele S; Schäfer U; Fazekas F; Hochmeister S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(9):E1678-E1687

Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis ‬.

Zeitelhofer M; Adzemovic MZ; Gomez-Cabrero D; Bergman P; Hochmeister S; N'diaye M; Paulson A; Ruhrmann S; Almgren M; Tegnér JN; Ekström TJ; Guerreiro-Cacais AO; Jagodic M
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2016;(117)

Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections.

Adzemovic MZ; Zeitelhofer M; Leisser M; Köck U; Kury A; Olsson T
Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63

Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney.

Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Ylä-Herttuala S; Eriksson U
Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

Lewandowski SA; Nilsson I; Fredriksson L; Lönnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
Article: PLOS ONE. 2016;11(5):e0154797

Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke.

Hochmeister S; Engel O; Adzemovic MZ; Pekar T; Kendlbacher P; Zeitelhofer M; Haindl M; Meisel A; Fazekas F; Seifert-Held T
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells.

Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; García-Ibáñez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Östman A; Bergh J; Poljakovic M; Genové G
Article: NEUROBIOLOGY OF DISEASE. 2014;71:220-233

Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.

Castelo-Branco G; Stridh P; Guerreiro-Cacais AO; Adzemovic MZ; Falcão AM; Marta M; Berglund R; Gillett A; Hamza KH; Lassmann H; Hermanson O; Jagodic M
Article: GENES AND IMMUNITY. 2014;15(7):457-465

The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation.

Laaksonen H; Guerreiro-Cacais AO; Adzemovic MZ; Parsa R; Zeitelhofer M; Jagodic M; Olsson T
Article: GLIA. 2014;62(7):1066-1074

Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system.

Kitic M; Wimmer I; Adzemovic M; Kögl N; Rudel A; Lassmann H; Bradl M
Article: EXPERIMENTAL NEUROLOGY. 2013;249:39-48

Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage.

Adzemovic MZ; Zeitelhofer M; Hochmeister S; Gustafsson SA; Jagodic M
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2013;333:e397-e398

A new model of focal inflammatory demyelination in the neocortex of the rat

Hochmeister S; Birngruber T; Zeitelhofer-Adzemovic M; Haindl M; Pieber TR; Sinner F
Article: PLOS ONE. 2013;8(2):e56586

Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response.

Adzemovic MV; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
Article: PLOS ONE. 2012;7(7):e39794

Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats.

Adzemovic MZ; Öckinger J; Zeitelhofer M; Hochmeister S; Beyeen AD; Paulson A; Gillett A; Thessen Hedreul M; Covacu R; Lassmann H; Olsson T; Jagodic M
Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6883-6890

IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.

Beyeen AD; Adzemovic MZ; Ockinger J; Stridh P; Becanovic K; Laaksonen H; Lassmann H; Harris RA; Hillert J; Alfredsson L; Celius EG; Harbo HF; Kockum I; Jagodic M; Olsson T
Article: PLOS ONE. 2010;5(9):e12716

Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat.

Stridh P; Thessen Hedreul M; Beyeen AD; Adzemovic MZ; Laaksonen H; Gillett A; Ockinger J; Marta M; Lassmann H; Becanovic K; Jagodic M; Olsson T
Article: ANNALS OF NEUROLOGY. 2009;66(5):630-643

Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo.

Bradl M; Misu T; Takahashi T; Watanabe M; Mader S; Reindl M; Adzemovic M; Bauer J; Berger T; Fujihara K; Itoyama Y; Lassmann H
Article: NEUROBIOLOGY OF DISEASE. 2009;35(3):368-375

The "window of susceptibility" for inflammation in the immature central nervous system is characterized by a leaky blood-brain barrier and the local expression of inflammatory chemokines.

Schoderboeck L; Adzemovic M; Nicolussi E-M; Crupinschi C; Hochmeister S; Fischer M-T; Lassmann H; Bradl M
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All other publications

Editorial comment: FRONTIERS IN NEUROLOGY. 2022;13:925216

Editorial: Neuropathology of Autoimmune Inflammatory Demyelination Disorders.

Zeitelhofer M; Hochmeister S; Adzemovic MZ
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:212-213

DNA methylation changes in brains from multiple sclerosis patients

Kular L; Needhamsen M; Zeitelhofer-Adzemovic M; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegner J; Beck S; Piehl F; Brundin L; Jagodic M
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2018;24:848-849

Investigation of astrocytic functions and involvement in remyelination in an animal model of multiple sclerosis

Haindl MT; Koeck U; Zeitelhofer-Adzemovic M; Fazekas F; Hochmeister S
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2016;22:167

Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats

Hochmeister S; Uecal M; Haindl M; Zeitelhofer-Adzemovic M; Theisl L; Strasser J; Ropele S; Schaefer U; Fazekas F
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2016;22:165

Investigation of remyelination facilitating factors produced by astrocytes in an animal model of multiple sclerosis

Haindl M; Koeck U; Zeitelhofer-Adzemovic M; Storch MK; Fazekas F; Hochmeister S
Corrigendum: PLOS ONE. 2015;10(4):e0123142

Correction: imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response.

PLOS ONE Staff
Meeting abstract: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):32

Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response

Adzemovic MZ; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2013;19(11):137-138

A new model of focal inflammatory demyelination in the neocortex of the rat

Hochmeister S; Birngruber T; Zeitelhofer-Adzemovic M; Haindl M; Sinner F

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2024

Degrees and Education

Docent, Karolinska Institutet, 2021

About me

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Articles

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