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About me

I am a postdoctoral-research fellow in Yenan Bryceson’s laboratory at HERM, Department of Medicine Huddinge. I joined the laboratory in 2015 when it was affiliated with the Center for Infectious Medicine (CIM). I am currently funded by a EMBO long-term fellowship and previously held a postdoctoral fellowship awarded by the Wenner-Gren Foundations. I received a PhD (Dr. rer. nat., summa cum laude) in biochemistry from the Ludwig-Maximilians University Munich, Germany, in December 2014 for work conducted in Christian Haass’ laboratory on the intramembrane-cleaving protease SPPL3. Prior to that I received my undergraduate training in biochemistry, molecular biology and immunology in Kiel, Germany.

Education

MAR 2009 TO DEC 2014

Graduate student, with Prof. Dr. Dr. Christian Haass & Dr. Regina Fluhrer (Adolf-Butenandt Institute, Ludwig-Maximilians University Munich, Germany)

OCT 2009 TO OCT 2013

Graduate program: Protein Dynamics in Health and Disease, Elite Network of Bavaria

AUG 2008 TO MAR 2009 

Diploma thesis with Prof. Dr. Ottmar Janßen (Institute of Immunology,
University Medical Center Schleswig-Holstein (UK-SH) & University of Kiel)

OCT 2004 TO MAR 2009

Diploma program: Biochemistry and Molecular Biology (Christian-Albrechts University of Kiel, Germany)

Research description

Working at the intersection of cell biology and clinical immunology, I am interested in the molecular mechanisms governing cytotoxic granule exocytosis in the lymphocyte context. Defects in key components of the lymphocyte cytotoxic machinery are associated with life-threatening primary immunodeficiensies in children and I am interrogating the cell biological mechanisms underlying these defects. In addition, I have a long-standing interest in glycobiology and intramembrane-cleaving proteasess.

Academic honours, awards and prizes

Fellowships

FEB 2016 TO JAN 2018: Longterm-fellowship, EMBO

FEB 2015 TO DEC 2015: Postdoctoral fellowship, Wenner-Gren Foundations, Stockholm

JAN 2010 TO JUN 2013: PhD fellowship, Hans und Ilse Breuer Foundation, Frankfurt, Germany

MAR 2007 TO MAR 2009: Fellowship, German National Academic Foundation (Studienstiftung des deutschen Volkes), Bonn, Germany

Prizes

JUN 2014: Best Poster Award, Glyco-T 2014 - 9th International Symposium on Glycosyltransfeases, Porto, Portugal

OCT 2009: Diploma Award, German Society for Biochemistry and Molecular Biology (GBM e.V.)

FEB 2008: Holsteiner Studienpreis, Christian-Albrechts University Kiel, Germany

Honours

JUN/JUL 2011: Selected participant, 61st Lindau Nobel Laureate Meeting 2011 (on physiology or medicine), Lindau, Germany

JUL/AUG 2010: Selected participant, Roche Continents 2010, Salburg, Austria

Publications

A RAB27A 5' untranslated region structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation
Tesi B, Rascon J, Chiang Scc, Burnyte B, Löfstedt A, Fasth A, et al
The Journal of allergy and clinical immunology 2018;():-

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7
Pastor Vb, Sahoo Ss, Boklan J, Schwabe Gc, Saribeyoglu E, Strahm B, et al
Haematologica 2018;103(3):427-437

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes Td, Chiang Scc, et al
Blood 2017;129(16):2266-2279

Natural killer cell biology illuminated by primary immunodeficiency syndromes in humans
Voss M, Bryceson Yt
Clinical immunology (Orlando, Fla.) 2017;177():29-42

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, et al
The Journal of biological chemistry 2016;291(1):318-33

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
Kuhn Ph, Voss M, Haug-kröper M, Schröder B, Schepers U, Bräse S, et al
Molecular & cellular proteomics : MCP 2015;14(6):1584-98

Differential protein-protein interactions of full length human FasL and FasL fragments generated by proteolysis
Lettau M, Voss M, Ebsen H, Kabelitz D, Janssen O
Experimental cell research 2014;320(2):290-301

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
Voss M, Künzel U, Higel F, Kuhn Ph, Colombo A, Fukumori A, et al
The EMBO journal 2014;33(24):2890-905

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
Voss M, Schröder B, Fluhrer R
Biochimica et biophysica acta 2013;1828(12):2828-39

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3)
Voss M, Fukumori A, Kuhn Ph, Künzel U, Klier B, Grammer G, et al
The Journal of biological chemistry 2012;287(52):43401-9

Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1
Schwarz N, Pruessmeyer J, Hess Fm, Dreymueller D, Pantaler E, Koelsch A, et al
Cellular and molecular life sciences : CMLS 2010;67(24):4233-48

The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes
Lettau M, Pieper J, Gerneth A, Lengl-janssen B, Voss M, Linkermann A, et al
Protein science : a publication of the Protein Society 2010;19(4):658-69

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
Voss M, Lettau M, Janssen O
BMC immunology 2009;10():53-

Posttranslational regulation of Fas ligand function
Voss M, Lettau M, Paulsen M, Janssen O
Cell communication and signaling : CCS 2008;6():11-

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