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PharmD 2004 . University Nilton Lins, Brazil

Masters in Pharmacology 2006 . University of Sao Paulo , Brazil

PhD in Pharmacology 2009 . University of Sao Paulo , Brazil

Research description

My major research interest are:

  • Nitric Oxide Biology
  • Alternative methods for nitric oxide detection and development of new methods 
  • Cardiovascular Pharmacology
  • Oxidative Stress

Recent Publications:


Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation.
Zhuge Z, Paulo L, Jahandideh A, Brandão M, Athayde-Filho P, Lundberg J, et al
Redox Biol 2017 Oct;13():163-169 

Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis.
Scarel-Caminaga R, Cera F, Pigossi S, Finoti L, Kim Y, Viana A, et al
Int J Mol Sci 2017 Jun;18(6): 

Profound differences between humans and rodents in the ability to concentrate salivary nitrate: Implications for translational research.
Montenegro M, Sundqvist M, Nihlén C, Hezel M, Carlström M, Weitzberg E, et al
Redox Biol 2016 12;10():206-210 

Blood Pressure-Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor.
Montenegro M, Sundqvist M, Larsen F, Zhuge Z, Carlström M, Weitzberg E, et al
Hypertension 2017 01;69(1):23-31 

Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.
Peleli M, Zollbrecht C, Montenegro M, Hezel M, Zhong J, Persson E, et al
Free Radic. Biol. Med. 2016 10;99():472-484 

Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension.
Porpino S, Zollbrecht C, Peleli M, Montenegro M, Brandão M, Athayde-Filho P, et al
Br. J. Pharmacol. 2016 07;173(14):2290-302 

Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.
Cai J, Zhong H, Wu J, Chen R, Yang H, Al-Abed Y, et al
Mol. Med. 2016 Mar;23(): 

The HIV protease inhibitor saquinavir inhibits HMGB1 driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88.
Pribis J, Al-Abed Y, Yang H, Gero D, Xu H, Montenegro M, et al
Mol. Med. 2015 Sep;():

Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension.
Pinheiro L, Amaral J, Ferreira G, Portella R, Ceron C, Montenegro M, et al
Free Radic. Biol. Med. 2015 Oct;87():252-62 

Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension.
Amaral J, Ferreira G, Pinheiro L, Montenegro M, Tanus-Santos J
Redox Biol 2015 Aug;5():340-6 

Nox4-dependent activation of cofilin mediates VSMC reorientation in response to cyclic stretching.
Montenegro M, Valdivia A, Smolensky A, Verma K, Taylor W, San Martín A
Free Radic. Biol. Med. 2015 Aug;85():288-94 

The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition.
Pinheiro L, Amaral J, Ferreira G, Montenegro M, Oliveira-Paula G, Tanus-Santos J
Nitric Oxide 2014 Aug;40():52-9 

Letter by Montenegro and Lundberg regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine".
Montenegro M, Lundberg J
Circulation 2014 Apr;129(13):e426