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About me

I am the head of the Heart Lab, Clinical Research Center, Karolinska Institutet at Huddinge. I am also a consultant in cardiothoracic surgery at Karolinska University Hospital with the focus area advanced heart failure and mechanical assist devices.

Education

COURSES AND DEGREES Medical Doctor Examination: 1997. Medical Doctor: 1999 Specialist in Cardiothoracic surgery 2006 DOCTORAL DEGREE 2007: Karolinska Institutet, Thoracic surgery, Cardiac Cell Therapy. Title: Cell transplantation with human mesenchymal or embryonic stem cells to the heart: experimental, molecular, immunological and echocardiographic studies. Supervisor: Professor Christer Sylvén, Co-supervisors: Göran Dellgren, M.D., Ph.D., Chief Physician, Thoracic Unit, Matthias Corbascio, Specialist Physician M.D., Ph.D., Thoracic Unit, Prof Katarina Le Blanc, M.D., Ph.D., Chief Physician Hematology Unit – all KI. Opponent: P Menasché, Paris. POSTDOC APPOINTMENTS PostDoc, registered 2008. 50% research, financed for 4 years. Supervisor: Professor Anders Franco-Cereceda, Dept of Molecular Medicine and Surgery CURRENT POSITION 2009-: Consultant Cardiothoracic surgery (Bitr Överläkare), Dept of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Solna, Sweden. PRIOR POSITIONS 2000-2006: Specialist training, Dept of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden.

Research description

The Heart Lab is a translational lab focusing on cardiac progenitor cells and immunological tolerance induction.

Academic honours, awards and prizes

SCIENTIFIC DISTINCTIONS

2003-     The Scandinavian Association of Thoracic Surgery conference (SATS) in Turku/ Suomi. Oral Presentation and awarded with the “C. Walton Lillehei Young Investigators Award”.

 

2003-     The Swedish Annual Cardiothoracic meeting in Stockholm. Oral Presentation and received the Limedic´s award for best presentation.

 

2010-    The Ingegerd and Viking Olov Björk Scholarship.

Publications

Human fetal cardiac progenitors: The role of stem cells and progenitors in the fetal and adult heart
Bulatovic I, Månsson-broberg A, Sylvén C, Grinnemo Kh
Best practice & research. Clinical obstetrics & gynaecology 2016;31():58-68

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Månsson-broberg A, Rodin S, Bulatovic I, Ibarra C, Löfling M, Genead R, et al
Stem cell reports 2016;6(4):607-617

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson Oe, Mougiakakos D, Heldring N, Bassi G, Johansson Hj, Dalén M, et al
Stem cells translational medicine 2015;4(10):1199-213

Percutaneous Fluoroscopic-Guided Endomyocardial Delivery in an Experimental Model of Left Ventricular Assist Device Support
Dalén M, Behfar A, Terzic A, Schiller P, Seron A, Sherman W, et al
Journal of cardiovascular translational research 2015;8(6):381-4

Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells
Bulatovic I, Ibarra C, Österholm C, Wang H, Beltrán-rodríguez A, Varas-godoy M, et al
PloS one 2015;10(3):e0120176-

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
Rodin S, Antonsson L, Niaudet C, Simonson Oe, Salmela E, Hansson Em, et al
Nature communications 2014;5():3195-

Emergency parallel mechanical circulatory support for ventricular fibrillation
Fux T, Gabrielsen A, Grinnemo Kh, Van Der Linden J, Svenarud P, Lund Lh
Circulation. Heart failure 2014;7(1):229-30

HeartWare left ventricular assist device thrombosis in aspirin non-responder
Dalén M, Sartipy U, Corbascio M, Lund Lh, Grinnemo Kh
Asian cardiovascular & thoracic annals 2014;22(2):203-4

Costimulation blockade induces foxp3(+) regulatory T cells to human embryonic stem cells
Ljung K, Simonson Oe, Felldin U, Wärdell E, Ibarra C, Antonsson L, et al
BioResearch open access 2013;2(6):455-8

Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism
Danielsson C, Brask J, Sköld Ac, Genead R, Andersson A, Andersson U, et al
Cardiovascular research 2013;97(1):23-32

Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors
Ibarra C, Vicencio Jm, Estrada M, Lin Yb, Rocco P, Rebellato P, et al
CIRCULATION RESEARCH 2013;112(2):236-45

[Minimally invasive implantation of left ventricular assist devices. Good results in the first procedure in Sweden]
Dalén M, Svenarud P, Lund Lh, Månsson-broberg A, Grinnemo Kh
Lakartidningen 2013;110(49-50):2242-3

Peripheral extracorporeal membrane oxygenation as short-term right ventricular support after HeartWare left ventricular assist device implantation
Dalén M, Sartipy U, Lund Lh, Fux T, Corbascio M, Svenarud P, et al
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2013;59(5):523-5

Verification of cell viability in bioengineered tissues and organs before clinical transplantation
Jungebluth P, Haag Jc, Lim Ml, Lemon G, Sjöqvist S, Gustafsson Y, et al
Biomaterials 2013;34(16):4057-67

Whole organ and tissue reconstruction in thoracic regenerative surgery
Lim Ml, Jungebluth P, Ajalloueian F, Friedrich Lh, Gilevich I, Grinnemo Kh, et al
Mayo Clinic proceedings 2013;88(10):1151-66

Intentional ABO-incompatible heart transplantation: a case report of 2 adult patients
Tydén G, Hagerman I, Grinnemo Kh, Svenarud P, Van Der Linden J, Kumlien G, et al
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012;31(12):1307-10

Ischemia-reperfusion injury and pregnancy initiate time-dependent and robust signs of up-regulation of cardiac progenitor cells
Genead R, Fischer H, Hussain A, Jaksch M, Andersson Ab, Ljung K, et al
PloS one 2012;7(5):e36804-

The International Translational Regenerative Medicine Center
Alexis Md, Grinnemo Kh, Jove R
REGENERATIVE MEDICINE 2012;7(6):74-5

Estrogen receptors do not influence angiogenesis after myocardial infarction
Broberg Am, Siddiqui Aj, Fischer H, Grinnemo Kh, Wardell E, Andersson Ab, et al
SCANDINAVIAN CARDIOVASCULAR JOURNAL 2011;45(4):215-22

Myocardial recovery in peri-partum cardiomyopathy after continuous flow left ventricular assist device
Lund Lh, Grinnemo Kh, Svenarud P, Van Der Linden J, Eriksson Mj
JOURNAL OF CARDIOTHORACIC SURGERY 2011;:150-

Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study
Jungebluth P, Alici E, Baiguera S, Le Blanc K, Blomberg P, Bozoky B, et al
LANCET 2011;378(9808):1997-2004

Depressed expression of angiogenic growth factors in the subacute phase of myocardial ischemia: a mechanism behind the remodeling plateau?
Siddiqui Aj, Fischer H, Widegren U, Grinnemo Kh, Hao Xj, Mansson-broberg A, et al
CORONARY ARTERY DISEASE 2010;21(2):65-71

Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization
Genead R, Danielsson C, Wardell E, Kjaeldgaard A, Westgren M, Sundstrom E, et al
STEM CELL RESEARCH 2010;4(1):69-76

Extracorporeal membrane oxygenation as a rescue of intractable ventricular fibrillation and bridge to heart transplantation
Fux T, Svenarud P, Grinnemo Kh, Albage A, Bredin F, Van Der Linden J, et al
EUROPEAN JOURNAL OF HEART FAILURE 2010;12(3):301-4

Islet-1 Cells Are Cardiac Progenitors Present During the Entire Lifespan: From the Embryonic Stage to Adulthood
Genead R, Danielsson C, Andersson Ab, Corbascio M, Franco-cereceda A, Sylven C, et al
STEM CELLS AND DEVELOPMENT 2010;19(10):1601-15

[Mechanical heart pump an alternative when transplantation is contraindicated. Permanent treatment now possible thanks to a rapid development]
Svenarud P, Grinnemo Kh, Van Der Linden J, Hultman J, Lund L, Pehrsson K, et al
Lakartidningen 2009;106(20):1354-6

Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart
Grinnemo Kh, Genead R, Kumagai-braesch M, Andersson A, Danielsson C, Mansson-broberg A, et al
STEM CELLS 2008;26(7):1850-7

Erythropoietin has an antiapoptotic effect after myocardial infarction and stimulates in vitro aortic ring sprouting
Broberg Am, Grinnemo Kh, Genead R, Danielsson C, Andersson Ab, Wardell E, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2008;371(1):75-8

Immunogenicity of human embryonic stem cells
Grinnemo Kh, Sylven C, Hovatta O, Dellgren G, Corbascio M
CELL AND TISSUE RESEARCH 2008;331(1):67-78

Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation
Mansson-broberg A, Siddiqui Aj, Genander M, Grinnemo Kh, Hao Xj, Andersson Ab, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2008;373(3):355-9

[Acute aortic dissection in pregnancy--risk of double death]
Franco-cereceda A, Grinnemo Kh, Anjou E, Falconer H, Samnegård A
Lakartidningen 2007;104(28-29):2087-8

Angiogenic effects of sequential release of VEGF-A(165) and PDGF-BB with alginate hydrogels after myocardial infarction
Hao Xj, Silva Ea, Mansson-broberg A, Grinnemo Kh, Siddiqui Aj, Dellgren G, et al
CARDIOVASCULAR RESEARCH 2007;75(1):178-85

Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines
Strom S, Inzunza J, Grinnemo Kh, Hohmnberg K, Matilainen E, Stromberg Am, et al
HUMAN REPRODUCTION 2007;22(12):3051-8

Myocardial angiogenesis after plasmid or adenoviral VEGF-A(165) gene transfer in rat myocardial infarction model
Hao Xj, Mansson-broberg A, Grinnemo Kh, Siddiqui Aj, Dellgren G, Brodin La, et al
CARDIOVASCULAR RESEARCH 2007;73(3):481-7

Ephrin-B2 influences angiogenesis in ischemic myocardium in mice
Mansson-broberg A, Siddiqui Aj, Hao X, Grinnemo Kh, Dellgren G, Sylven C, et al
EUROPEAN HEART JOURNAL 2006;:68-68

Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings
Grinnemo Kh, Kumagai-braesch M, Mansson-broberg A, Skottman H, Hao Xj, Siddiqui A, et al
REPRODUCTIVE BIOMEDICINE ONLINE 2006;13(5):712-24

Human mesenchymal stem cells do not differentiate into cardiomyocytes in a cardiac ischemic xenomodel
Grinnemo Kh, Mansson-broberg A, Leblanc K, Corbascio M, Wardell E, Siddiqui Aj, et al
ANNALS OF MEDICINE 2006;38(2):144-53

Antagonism of the renin-angiotensin system can counteract cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in the normal heart
Siddiqui Aj, Mansson-broberg M, Gustafsson T, Grinnemo Kh, Dellgren G, Hao X, et al
AMERICAN JOURNAL OF HYPERTENSION 2005;18(10):1347-52

Human embryonic stem cells induce immunity when transplanted to immunologically competent mice
Grinnemo Kh, Mansson-broberg A, Teerijoki H, Kumagai-braesch M, Hovatta O, Sylven C, et al
EUROPEAN HEART JOURNAL 2005;:321-321

Human mesenchymal stem cells do not differentiate into cardiac myocytes in ischaemic myocardium
Grinnemo Kh, Mansson-broberg A, Leblanc K, Siddiqui Aj, Hao X, Sylven C, et al
EUROPEAN HEART JOURNAL 2005;:685-685

Tacrolimus seem to inhibit discordant xenorejection of human embryonic stem cells: a study in the human-to-pig model
Grinnemo Kh, Mansson-broberg A, Hao X, Siddiqui Aj, Hovatta O, Sylven C, et al
EUROPEAN HEART JOURNAL 2005;:531-531

Therapeutic endogenous ligand/receptor induction of the VEGF-angiopoietin system after intramyocardial gene transfer during myocardial ischaemia
Siddiqui Aj, Gustafsson T, Grinnemo Kh, Dellgren G, Xin H, Mansson-broberg A, et al
EUROPEAN HEART JOURNAL 2005;:66-66

Angiogenic and cardiac functional effects of dual gene transfer of VEGF-A(165) and PDGF-BB after myocardial infarction
Hao Xj, Mansson-broberg A, Blomberg P, Dellgren G, Siddiqui Aj, Grinnemo Kh, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2004;322(1):292-6

Angiogenic effects of dual gene transfer of bFGF and PDGF-BB after myocardial infarction
Hao X, Mansson-broberg A, Gustafsson T, Grinnemo Kh, Blomberg P, Siddiqui Aj, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2004;315(4):1058-63

Simvastatin enhances myocardial angiogenesis induced by vascular endothelial growth factor gene transfer
Siddiqui Aj, Gustafsson T, Fischer H, Widegren U, Hao X, Mansson-broberg A, et al
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2004;37(6):1235-44

Surgical closure of patent foramen ovale in patients with suspected paradoxical embolism: long-term results
Gasiavelis N, Grinnemo Kh, Lindblom D, Dellgren G
SCANDINAVIAN CARDIOVASCULAR JOURNAL 2004;38(6):375-9

Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium
Grinnemo Kh, Mansson A, Dellgren G, Klingberg D, Wardell E, Drvota V, et al
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2004;127(5):1293-300

Simvastatin enhances myocardial angiogenesis induced by vascular endothelial growth factor gene transfer
Siddiqui Aj, Xaojin H, Broberg Am, Grinnemo Kh, Wardell E, Sylven C
EUROPEAN HEART JOURNAL 2003;:690-690

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