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About me

I have received my PhD at Karolinska Institute in the field of Epigenetics and Bioinformatics under the supervision of Professor Karl Ekwall. I have started my postdoctoral work at Karolinska Institute, Dept. of molecular Biochemistry and Biophysics where I was involved in analyzing high-throughput sequencing data such as RNAseq, miRNA and Single-cell RNA sequencing.

In 2012 I have started another post-doctoral work at the Department of Biosciences and Nutrition in the "Estrogen signaling research group" headed by Professor Karin Dahlman-Wright. From 2014 I am working as a Senior Researcher in the same group. I am working in close collaboration with the Karolinska Institute core facility for Bioinformatics and Expression Analysis (BEA, www.bea.ki.se).

Education

PhD in Cell & Molecular Biology with specialization in Epigenetics and Bioinformatics, Department of Biosciences and Nutrition, Karolinska Institutet, Sweden. Dissertation Title: Genome-wide patterns of histone modifications in fission yeast (http://diss.kib.ki.se/2010/978-91-7409-747-4/).

M.Sc. in Analytical Chemistry from Calcutta University, India.

Research description

My present research focus is on the epigenetic mechanisms in the development of Type 2 Diabetes.

 

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Academic honours, awards and prizes

International Conference on Biotechnology & Bioinformatics (ICBB-2014) “Young Investigator Award” in February 2014. 

100,000 SEK from Postgraduate program in Developmental Biology and Cellular Signaling (DECS) for running a course for PhD students Titled “A combination of in vivo and in silico methods to determine genome-wide protein targets” at Karolinska Institutet in the year 2013.

The prestigious Strategic Research Programme in Diabetes (SRP) post-doctoral research fellowship in 2012.

A travel award from The Chromatin Plasticity Network to attend Computational and Statistical Aspects of MicroArray Analysis (CSAMA08) June 15-20, 2008 in Bressanone, Italy.

Södertörns högskola (Södertörn University College) PhD Study grant to perform the PhD study at Karolinska Institutet from 2005-2010.

Publications

c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer
He H, Sinha I, Fan R, Haldosen La, Yan F, Zhao C, et al
Oncogene 2018;37(19):2586-2600

Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis
Bialesova L, Kulyté A, Petrus P, Sinha I, Laurencikiene J, Zhao C, et al
Scientific reports 2017;7(1):10152-

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
Kirchner H, Sinha I, Gao H, Ruby Ma, Schönke M, Lindvall Jm, et al
Molecular metabolism 2016;5(3):171-183

AP-1 Is a Key Regulator of Proinflammatory Cytokine TNFα-mediated Triple-negative Breast Cancer Progression
Qiao Y, He H, Jonsson P, Sinha I, Zhao C, Dahlman-wright K
The Journal of biological chemistry 2016;291(10):5068-79

Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery
Berglind D, Müller P, Willmer M, Sinha I, Tynelius P, Näslund E, et al
Obesity (Silver Spring, Md.) 2016;24(1):250-61

Erratum to: The epigenetic signature of systemic insulin resistance in obese women
Arner P, Sahlqvist As, Sinha I, Xu H, Yao X, Waterworth D, et al
Diabetologia 2016;59(12):2728-

Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism
Jia M, Andreassen T, Jensen L, Bathen Tf, Sinha I, Gao H, et al
Cancer research 2016;76(19):5634-5646

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone
Wang Y, Fisahn A, Sinha I, Nguyen Dp, Sterzenbach U, Lallemend F, et al
Scientific reports 2016;6():18617-

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
Martínez-redondo V, Jannig Pr, Correia Jc, Ferreira Dm, Cervenka I, Lindvall Jm, et al
The Journal of biological chemistry 2016;291(29):15169-84

RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J, Zhao C, Zhuang T, Jonsson P, Sinha I, Williams C, et al
Oncogene 2016;35(15):1955-64

The epigenetic signature of systemic insulin resistance in obese women
Arner P, Sahlqvist As, Sinha I, Xu H, Yao X, Waterworth D, et al
Diabetologia 2016;59(11):2393-2405

A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin
Svensson Jp, Shukla M, Menendez-benito V, Norman-axelsson U, Audergon P, Sinha I, et al
Genome research 2015;25(6):872-83

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia Jc, Massart J, De Boer Jf, Porsmyr-palmertz M, Martínez-redondo V, Agudelo Lz, et al
Molecular metabolism 2015;4(12):891-902

The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Arner P, Sinha I, Thorell A, Rydén M, Dahlman-wright K, Dahlman I
Clinical epigenetics 2015;7():93-

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Dahlman I, Sinha I, Gao H, Brodin D, Thorell A, Rydén M, et al
International journal of obesity (2005) 2015;39(6):910-9

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer
Zhao C, Qiao Y, Jonsson P, Wang J, Xu L, Rouhi P, et al
Cancer research 2014;74(14):3983-94

Erg channel is critical in controlling cell volume during cell cycle in embryonic stem cells
Abdelhady S, Kitambi Ss, Lundin V, Aufschnaiter R, Sekyrova P, Sinha I, et al
PloS one 2013;8(8):e72409-

Positional differences of axon growth rates between sensory neurons encoded by Runx3
Lallemend F, Sterzenbach U, Hadjab-lallemend S, Aquino Jb, Castelo-branco G, Sinha I, et al
The EMBO journal 2012;31(18):3718-29

Genome-wide mapping of histone modifications and mass spectrometry reveal H4 acetylation bias and H3K36 methylation at gene promoters in fission yeast
Sinha I, Buchanan L, Ronnerblad M, Bonilla C, Durand-dubief M, Shevchenko A, et al
EPIGENOMICS 2010;2(3):377-93

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing
Durand-dubief M, Sinha I, Fagerstroem-billai F, Bonilla C, Wright A, Grunstein M, et al
EMBO JOURNAL 2007;26(10):2477-88

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions
Zhu Xf, Wiren M, Sinha I, Rasmussen Nn, Linder T, Holmberg S, et al
MOLECULAR CELL 2006;22(2):169-78

Genome-wide patterns of histone modifications in fission yeast
Sinha I, Wiren M, Ekwall K
CHROMOSOME RESEARCH 2006;14(1):95-105

Genome wide analysis of nucleosome density histone acetylation and HDAC function in fission yeast
Wiren M, Silverstein Ra, Sinha I, Walfridsson J, Lee Hm, Laurenson P, et al
EMBO JOURNAL 2005;24(16):2906-18

Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro
Singh V, Sinha I, Sadhale Pp
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2005;334(4):1149-58

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