Henrik Biverstål

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Articles

Article: NEURAL REGENERATION RESEARCH. 2025;20(3):873-886
Pro-resolving lipid mediator reduces amyloid-β42-induced gene expression in human monocyte-derived microglia
Wang Y; Zhang X; Biverstal H; Bazan NG; Tan S; Li N; Ohshima M; Schultzberg M; Li X
Article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: NATURE COMMUNICATIONS. 2023;14(1):5804
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents
He Y; Kaya I; Shariatgorji R; Lundkvist J; Wahlberg LU; Nilsson A; Mamula D; Kehr J; Zareba-Paslawska J; Biverstal H; Chergui K; Zhang X; Andren PE; Svenningsson P
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2023;125:103843
Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain
Shimozawa M; Tigro H; Biverstal H; Shevchenko G; Bergquist J; Moaddel R; Johansson J; Nilsson P
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: SCIENTIFIC REPORTS. 2023;13(1):985
Food protein-derived amyloids do not accelerate amyloid β aggregation
Rahman MM; Pires RS; Herneke A; Gowda V; Langton M; Biverstal H; Lendel C
Article: JACS AU. 2022;2(11):2571-2584
Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease
Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain
Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
Article: CHEMICAL SCIENCE. 2022;13(2):536-553
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation
Nagaraj M; Najarzadeh Z; Pansieri J; Biverstal H; Musteikyte G; Smirnovas V; Matthews S; Emanuelsson C; Johansson J; Buxbaum JN; Morozova-Roche L; Otzen DE
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808
Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro
Oliveira DV; Svensson J; Zhong X; Biverstal H; Chen G; Karlstrom H
Article: SCIENTIFIC REPORTS. 2020;10(1):21765
Functionalization of amyloid fibrils via the Bri2 BRICHOS domain
Biverstal H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
Article: THE FEBS JOURNAL. 2020;287(13):2823-2833
High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry
Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234
Metal ion coordination delays amyloid-? peptide self-assembly by forming an aggregation?inert complex
Wallin C; Jarvet J; Biverstal H; Warmlander S; Danielsson J; Graslund A; Abelein A
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
Article: SCIENTIFIC REPORTS. 2020;10(1):235
High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477
Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity
Honcharenko D; Juneja A; Roshan F; Maity J; Galan-Acosta L; Biverstal H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Stromberg R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice
Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
Article: NATURE COMMUNICATIONS. 2017;8(1):2081
Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: JOURNAL OF NEUROSCIENCE METHODS. 2017;290:145-150
Improved method for cannula fixation for long-term intracerebral brain infusion
Sike A; Wengenroth J; Upite J; Bruning T; Eiriz I; Santha P; Biverstal H; Jansone B; Haugen HJ; Krohn M; Pahnke J
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2017;5(1):49
Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Steffen J; Krohn M; Schwitlick C; Bruning T; Paarmann K; Pietrzik CU; Biverstal H; Jansone B; Langer O; Pahnke J
Article: NATURE COMMUNICATIONS. 2017;8:15504
Efficient protein production inspired by how spiders make silk
Kronqvist N; Sarr M; Lindqvist A; Nordling K; Otikovs M; Venturi L; Pioselli B; Purhonen P; Landreh M; Biverstal H; Toleikis Z; Sjoberg L; Robinson CV; Pelizzi N; Jornvall H; Hebert H; Jaudzems K; Curstedt T; Rising A; Johansson J
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila
Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(8):835-843
Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation
Biverstal H; Dolfe L; Hermansson E; Leppert A; Reifenrath M; Winblad B; Presto J; Johansson J
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2015;72(8):1599-1611
BRI2 ectodomain affects Aβ₄₂ fibrillation and tau truncation in human neuroblastoma cells
Del Campo M; Oliveira CR; Scheper W; Zwart R; Korth C; Mueller-Schiffmann A; Kostallas G; Biverstal H; Presto J; Johansson J; Hoozemans JJ; Pereira CF; Teunissen CE
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2015;22(3):207-213
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Cohen SIA; Arosio P; Presto J; Kurudenkandy FR; Biverstal H; Dolfe L; Dunning C; Yang X; Frohm B; Vendruscolo M; Johansson J; Dobson CM; Fisahn A; Knowles TPJ; Linse S
Article: ORGANIC AND BIOMOLECULAR CHEMISTRY. 2014;12(34):6684-6693
Synthesis and evaluation of antineurotoxicity properties of an amyloid-β peptide targeting ligand containing a triamino acid
Honcharenko D; Bose PP; Maity J; Kurudenkandy FR; Juneja A; Floistrup E; Biverstal H; Johansson J; Nilsson L; Fisahn A; Stromberg R
Article: JOURNAL OF NEUROSCIENCE. 2014;34(34):11416-11425
Amyloid-β-Induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations Is Prevented by Interference with Peptide Conformation Change and Aggregation
Kurudenkandy FR; Zilberter M; Biverstal H; Presto J; Honcharenko D; Stromberg R; Johansson J; Winblad B; Fisahn A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(37):31608-31617
BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide
Willander H; Presto J; Askarieh G; Biverstal H; Frohm B; Knight SD; Johansson J; Linse S
Journal article: ALZHEIMER'S AND DEMENTIA. 2011;7(4S_Part_24):e21-e22
P4‐316: Stabilization of neurotoxic Alzheimer amyloid‐beta oligomers by protein engineering
Dubnovitsky A; Sandberg A; Luheshi L; Söllvander S; de Barros TP; Macao B; Knowles T; Biverstål H; Lendel C; Ekholm‐Petterson F; Lannfelt L; Dobson C; Härd T
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1808(1):298-306
Laurdan and di-4-ANEPPDHQ do not respond to membrane-inserted peptides and are good probes for lipid packing
Dinic J; Biverstahl H; Maler L; Parmryd I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(35):15595-15600
Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
Sandberg A; Luheshi LM; Sollvander S; de Barros TP; Macao B; Knowles TPJ; Biverstal H; Lendel C; Ekholm-Petterson F; Dubnovitsky A; Lannfelt L; Dobson CM; Hard T
Article: MOLECULAR PLANT. 2009;2(6):1298-1309
Dual Targeting to Mitochondria and Chloroplasts: Characterization of Thr-tRNA Synthetase Targeting Peptide
Berglund A-K; Spanning E; Biverstahl H; Maddalo G; Tellgren-Roth C; Maler L; Glaser E
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1788(9):1976-1986
Biophysical studies of the membrane location of the voltage-gated sensors in the HsapBK and KvAP K⁺ channels
Biverstahl H; Lind J; Bodor A; Maler L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1768(1):115-121
The membrane-induced structure of melittin is correlated with the fluidity of the lipids
Andersson A; Biverstahl H; Nordin J; Danielsson J; Lindahl E; Maler L
Article: BIOPHYSICAL JOURNAL. 2006;91(4):L29-L31
Real-time transmembrane translocation of penetratin driven by light-generated proton pumping
Bjorklund J; Biverstahl H; Graslund A; Maler L; Brzezinski P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;349(4):847-860
Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different
Ståhl A; Nilsson S; Lundberg P; Bhushan S; Biverståhl H; Moberg P; Morisset M; Vener A; Mäler L; Langel U; Glaser E
Article: BIOCHEMISTRY. 2004;43(47):14940-14947
NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein
Biverståhl H; Andersson A; Gräslund A; Mäler L
Article: THE FEBS JOURNAL. 2003;270(14):3055-3063
Structure and positioning comparison of two variants of penetratin in two different membrane mimicking systems by NMR
Lindberg M; Biverståhl H; Gräslund A; Mäler L
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Preprint: BIORXIV. 2023
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstål H; Otzen DE; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54
Structural insights into aggregation hotspots on Alzheimer's associated amyloid-β fibrils blocked by the BRICHOS chaperone
Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S168
Targeting a-synuclein amyloid aggregates with the BRICHOS domain - basis for treatment of Parkinson's disease
Adam L; Kumar R; Molenkamp W; Alkenayeh R; Biverstal H; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S89
Molecular mechanisms of amyloid-β self-assembly and chaperone-mediated inhibition can be translated to in vivo-derived fibril seeds
Kumar R; Garcia LEA; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Preprint: BIORXIV. 2021
Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue
Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Review: BIOCHIMIE. 2017;140:176-192
Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity
Aleksis R; Oleskovs F; Jaudzems K; Pahnke J; Biverstal H
Conference publication: PROTEIN SCIENCE. 2017;26:31-32
Bri2 BRICHOS molecular chaperone activity is decoupled from its ability to inhibit amyloid fibril formation
Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
Conference publication: PROTEIN SCIENCE. 2014;23:90
Limited Proteolysis And Dissociation Of Trimeric State Of The BRICHOS Domain Increase Its Anti-Amyloid Activity
Biverstal H; Dolfe L; Hermansson E; Presto J; Johansson J
Conference publication: NEONATOLOGY. 2014;105(4):359
The BRICHOS Domain: Structure, Function and Involvement in Interstitial Lung Disease
Johansson J; Presto J; Biverstal H; Dolfe L

Grants

PET analyses of ABC transporter function for diagnostics and stratification of dementia patients
Swedish Research Council
1 January 2021 - 31 December 2023
Propagation behavior of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier
Swedish Research Council
1 December 2015 - 30 November 2018

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