Identification of environmental and genetic determinants for lung development in children is of utmost importance, given its long term consequence on disease development later in life. My phD-project aims to investigate lung function in children and adolescents. I aim to advance the understanding about the timing of air pollution exposure (potential time windows of vulnerability) in relation to lung function in childhood or early adolescents and the complex interplay between genetic and traffic-related air pollutants affecting lung function growth. I am focusing in genes involved in inflammatory and oxidative pathway. Lung function impairment and growth will further be studied in relation to environmental exposures, perinatal events and respiratory symptoms. My phD-project is mainly based on a Swedish birth cohort (BAMSE) that allows for unique investigation of lung growth and respiratory disease in a large number of children up to 16 years.