Daniel Ketelhuth
Principal Researcher
| Docent
E-mail: daniel.ketelhuth@ki.se
Visiting address: BioClinicum,plan 8, Karolinska universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardiov m Olofsson P Gisterå A, 171 77 Stockholm
About me
- Assoc. Professor of Experimental Cardiology
1999 Biochemical-pharmacist - Faculty
of Pharmaceutical Sciences, University of São Paulo (USP), Riberião Preto,
Brazil.
2005 PhD in immunology. Institute of
Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil.
2005 – 2010 Postdoctoral fellow, Experimental Cardiovascular
Research Unit, CMM, Karolinska University Hospital, Stockholm, Sweden.
Research
- Cardiovascular diseases (CVDs) are the leading cause of mortality and
disability worldwide, imposing a significant burden on society. Coronary
heart disease and cerebrovascular disease, the two most common forms of
cardiovascular disease, are caused by acute complications of atherosclerosis.
CVD kills over 17 million individuals every year, which accounts for one
third of all global deaths.
Although population-wide management of traditional risk factors for CVDs
(e.g. hyperlipidemia, high-blood pressure, glycaemia) has reduced the
incidence of cardiovascular events in developed countries, substantial
residual risk remains. Thus, translational therapeutic strategies targeting
novel molecular pathways regulating atherosclerosis are needed.
Atherosclerosis is a chronic inflammatory disease initiated by retention and
accumulation of lipids in the artery wall, especially low-density lipoprotein
(LDL), leading to maladaptive responses of innate and adaptive immune cells.
Notably, metabolism and activation are fully integrated in immune cells, and
systemic or microenvironmental changes in metabolism have been shown to
modulate their responses.
In pioneer work, we have identified several targets to modulate the unwanted
immune responses in the artery wall, including components of LDL that can
trigger innate and adaptive immune cells, and metabolites of the essential
amino acid tryptophan, via the Kynurenine pathway. Our research indicates
that metabolites are not just ‘fuels’ in their metabolic pathways, but
that they can also act as signalling molecules in immune cells and influence
atherosclerosis. By increasing the understanding of the immunometabolic
reactions controlling immune responses in atherogenesis, our research will
lead to the development of new drugs to treat and prevent atherosclerotic
CVDs.
*Selected publications*
[pubmed:28194913]
[pubmed:28420668]
[pubmed:26892965]
[pubmed:25848033]
[pubmed:25750192]
[pubmed:24816772]
[pubmed:23903754]
[pubmed:22711758]
[pubmed:22064596]
[pubmed:20439543]
Articles
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Article: REDOX BIOLOGY. 2023;64:102773
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(8):1510-1523
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Article: CARDIOVASCULAR RESEARCH. 2023;119(7):1524-1536
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Article: CIRCULATION RESEARCH. 2022;130(12):1869-1887
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(9):5203
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Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:831039
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Article: FRONTIERS IN PHARMACOLOGY. 2022;13:988561
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Article: JOURNAL OF HYPERTENSION. 2022;40(1):153-162
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883
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Article: EUROPEAN HEART JOURNAL OPEN. 2021;1(1):oeab021
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Article: METABOLITES. 2021;11(7):411
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Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(1):53-68
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Article: CARDIOVASCULAR RESEARCH. 2020;116(12):1948-1957
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Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2685-2700
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Article: ATHEROSCLEROSIS. 2020;307:21-31
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Article: STEM CELL RESEARCH & THERAPY. 2019;10(1):371
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Article: CYTOKINE. 2019;122:154148
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Article: SCIENTIFIC REPORTS. 2019;9(1):12150
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Article: BIOMOLECULES. 2019;9(8):E386-386
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Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)
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Article: CIRCULATION. 2019;139(21):2466-2482
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Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2019;62(4):159-168
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Article: CIRCULATION. 2018;138(22):2513-2526
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Article: CIRCULATION. 2018;138(16):1693-1705
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
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Article: EUROPEAN HEART JOURNAL. 2018;39(27):2562-2573
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Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2018;25(9):948-955
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Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
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Article: FRONTIERS IN IMMUNOLOGY. 2018;9:950
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Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2018;2018:1975167-9
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Article: SCIENTIFIC REPORTS. 2017;7(1):15655
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(11):1918-1924
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Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(7):1296-1316
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Article: CIRCULATION RESEARCH. 2017;120(11):1740-1753
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Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(4):383-397
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Article: SCIENTIFIC REPORTS. 2016;6:28337
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Article: CIRCULATION RESEARCH. 2016;118(4):668-678
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(1):25-36
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Article: DIABETES. 2015;64(10):3425-3438
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Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):105-109
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Article: CARDIOVASCULAR RESEARCH. 2015;106(2):295-302
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038
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Article: METHODS IN MOLECULAR BIOLOGY. 2015;1339:149-159
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Article: THROMBOSIS AND HAEMOSTASIS. 2014;112(2):332-341
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Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(1):49-58
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Article: CURRENT PHARMACEUTICAL DESIGN. 2013;19(33):5850-5858
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Article: SCIENCE TRANSLATIONAL MEDICINE. 2013;5(196):196ra100
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Article: CARDIOVASCULAR RESEARCH. 2013;99(2):364-373
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(6):1189-1196
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(3):1323-1334
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Article: PLOS ONE. 2013;8(10):e76893
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Article: EUROPEAN HEART JOURNAL. 2012;33(16):2025-2034
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Article: IMMUNOBIOLOGY. 2012;217(5):540-547
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Article: CIRCULATION. 2011;124(22):2433-7
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Article: THROMBOSIS AND HAEMOSTASIS. 2011;106(5):779-786
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Article: CURRENT ATHEROSCLEROSIS REPORTS. 2011;13(2):162-169
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Article: CIRCULATION. 2011;123(10):1083-1091
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Article: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS. 2010;17(8):844-857
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Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):1081-1093
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(5):946-952
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Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(4):456-462
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Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2008;22(5-6):549-556
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Article: JOURNAL OF LIPID RESEARCH. 2006;47(7):1526-1534
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Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2004;24(2):170-176
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Article: BIOCHIMIE. 2003;85(10):983-991
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Article: INFLAMMATION RESEARCH. 2003;52(5):215-220
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Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2002;84(2):309-323
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All other publications
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Editorial comment: EUROPEAN HEART JOURNAL OPEN. 2022;2(6):oeac084
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Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2022;291(5):530-532
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Review: CLINICAL SCIENCE. 2022;136(6):435-454
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Meeting abstract: ATHEROSCLEROSIS. 2019;287:E1
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Review: CARDIOVASCULAR RESEARCH. 2019;115(9):1408-1415
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Review: CARDIOVASCULAR RESEARCH. 2019;115(9):1385-1392
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Review: CARDIOVASCULAR RESEARCH. 2019;115(1):10-19
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Review: CURRENT OPINION IN LIPIDOLOGY. 2018;29(5):375-380
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Meeting abstract: ATHEROSCLEROSIS. 2018;275:E5
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Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
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Meeting abstract: CARDIOVASCULAR RESEARCH. 2018;114:s140
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Meeting abstract: ATHEROSCLEROSIS. 2017;263:E12
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Review: CIRCULATION JOURNAL. 2015;79(5):924-933
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Review: HAMOSTASEOLOGIE. 2015;35(2):128-136
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Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):E140
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Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):E88-E89
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):3
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):61-62
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):80
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Review: PROGRESS IN CARDIOVASCULAR DISEASES. 2010;52(5):410-428
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):521
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):586-587
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):237
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Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2017