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About me

PhD Student in the lab of Ernest Arenas


MSc - Stockholm University

BSc - University of Wisconsin - Madison

Research description

Interested in studying and characterizing the function and mechanisms by which components of the Wnt/PCP signalling pathway regulate the development of midbrain DA neurons in vivo and application of Wnts to improve protocols for the DA differentiation of stem cells. Also interested in single-cell heterogeneity in the developing midbrain.

Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP.
Zhang D, Yang S, Toledo E, Gyllborg D, Saltó C, Carlos Villaescusa J, et al
Sci Signal 2017 Aug;10(493):

Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease.
Toledo E, Gyllborg D, Arenas E
Br. J. Pharmacol. 2017 Dec;174(24):4716-4724

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.
Kaucka M, Zikmund T, Tesarova M, Gyllborg D, Hellander A, Jaros J, et al
Elife 2017 04;6():

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, et al
Cell 2016 Oct;167(2):566-580.e19

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
Villaescusa J, Li B, Toledo E, Rivetti di Val Cervo P, Yang S, Stott S, et al
EMBO J. 2016 09;35(18):1963-78

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system.
Marques S, Zeisel A, Codeluppi S, van Bruggen D, Mendanha Falcão A, Xiao L, et al
Science 2016 Jun;352(6291):1326-1329

Analysis of neural crest-derived clones reveals novel aspects of facial development.
Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, et al
Sci Adv 2016 08;2(8):e1600060

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