Aleksander Mathe

Publications
CV
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Articles

Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;57:1-14

Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.

Carboni L; El Khoury A; Beiderbeck DI; Neumann ID; Mathé AA
Article: ACTA NEUROPSYCHIATRICA. 2022;34(2):86-92

Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression.

Stiernborg M; Efstathopoulos P; Lennartsson A; Lavebratt C; Mathé AA
Article: MOLECULAR PSYCHIATRY. 2021;26(9):5140-5149

Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance.

Nasca C; Dobbin J; Bigio B; Watson K; de Angelis P; Kautz M; Cochran A; Mathé AA; Kocsis JH; Lee FS; Murrough JW; McEwen BS; Rasgon N
Article: SCIENTIFIC REPORTS. 2021;11(1):11856

The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression.

Melas PA; Wirf M; André H; Jayaram-Lindström N; Mathé AA; Steensland P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2020;23(12):783-790

A Randomized Controlled Trial of Intranasal Neuropeptide Y in Patients With Major Depressive Disorder.

Mathé AA; Michaneck M; Berg E; Charney DS; Murrough JW
Article: CELLS. 2020;9(8):E1818-1818

Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment.

Carboni L; Pischedda F; Piccoli G; Lauria M; Musazzi L; Popoli M; Mathé AA; Domenici E
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;32:94-103

Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner.

Ardalan M; Elfving B; Rafati AH; Mansouri M; Zarate CA; Mathe AA; Wegener G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;31:69-85

Gene expression signature of antidepressant treatment response/non-response in Flinders Sensitive Line rats subjected to maternal separation.

Marchetti L; Lauria M; Caberlotto L; Musazzi L; Popoli M; Mathé AA; Domenici E; Carboni L
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:304

Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses.

Schintu N; Zhang X; Stroth N; Mathé AA; Andrén PE; Svenningsson P
Article: BEHAVIOURAL BRAIN RESEARCH. 2019;367:28-34

Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats.

Tillmann S; Skibdal HE; Christiansen SH; Gøtzsche CR; Hassan M; Mathé AA; Wegener G; Woldbye DPD
Article: ACTA NEUROPSYCHIATRICA. 2019;31(2):93-99

CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment.

Angelucci F; Ellenbroek BA; El Khoury A; Mathé AA
Article: BEHAVIOURAL BRAIN RESEARCH. 2018;351:93-103

Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression.

Sanchez C; El Khoury A; Hassan M; Wegener G; Mathé AA
Article: NEUROPSYCHOPHARMACOLOGY. 2018;43(10):2134-2145

Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression.

Carboni L; Marchetti L; Lauria M; Gass P; Vollmayr B; Redfern A; Jones L; Razzoli M; Malki K; Begni V; Riva MA; Domenici E; Caberlotto L; Mathé AA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(34):8627-8632

Acetyl-l-carnitine deficiency in patients with major depressive disorder.

Nasca C; Bigio B; Lee FS; Young SP; Kautz MM; Albright A; Beasley J; Millington DS; Mathé AA; Kocsis JH; Murrough JW; McEwen BS; Rasgon N
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2018;28(1):159-170

Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.

Cohen H; Vainer E; Zeev K; Zohar J; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(1):3-11

A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder.

Sayed S; Van Dam NT; Horn SR; Kautz MM; Parides M; Costi S; Collins KA; Iacoviello B; Iosifescu DV; Mathé AA; Southwick SM; Feder A; Charney DS; Murrough JW
Article: ACTA NEUROPSYCHIATRICA. 2017;29(1):54-58

Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.

Liu X-C; Erhardt S; Goiny M; Engberg G; Mathé AA
Article: FRONTIERS IN PSYCHIATRY. 2017;8:102

Neuropeptide Y and Calcitonin Gene-Related Peptide in Cerebrospinal Fluid in Parkinson's Disease with Comorbid Depression versus Patients with Major Depressive Disorder.

Svenningsson P; Pålhagen S; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(12):pyw069

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.

Wei YB; Melas PA; Villaescusa JC; Liu JJ; Xu N; Christiansen SH; Elbrønd-Bek H; Woldbye DPD; Wegener G; Mathé AA; Lavebratt C
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(10):e917

The wake-promoting drug modafinil stimulates specific hypothalamic circuits to promote adaptive stress responses in an animal model of PTSD.

Cohen S; Ifergane G; Vainer E; Matar MA; Kaplan Z; Zohar J; Mathé AA; Cohen H
Article: NEUROPEPTIDES. 2016;59:83-88

Gene-environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions.

Ellenbroek BA; Angelucci F; Husum H; Mathé AA
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2016;81:36-45

Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression.

Rummel J; Voget M; Hadar R; Ewing S; Sohr R; Klein J; Sartorius A; Heinz A; Mathé AA; Vollmayr B; Winter C
Article: BRAIN STRUCTURE & FUNCTION. 2016;221(7):3521-3546

Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study.

Adori C; Barde S; Vas S; Ebner K; Su J; Svensson C; Mathé AA; Singewald N; Reinscheid RR; Uhlén M; Kultima K; Bagdy G; Hökfelt T
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e869

Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression.

Wei YB; Liu JJ; Villaescusa JC; Åberg E; Brené S; Wegener G; Mathé AA; Lavebratt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(28):7906-7911

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance.

Bigio B; Mathé AA; Sousa VC; Zelli D; Svenningsson P; McEwen BS; Nasca C
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;291:299-305

Altered local field potential activity and serotonergic neurotransmission are further characteristics of the Flinders sensitive line rat model of depression.

Voget M; Rummel J; Avchalumov Y; Sohr R; Haumesser JK; Rea E; Mathé AA; Hadar R; van Riesen C; Winter C
Article: BRAIN STIMULATION. 2015;8(4):714-723

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System.

Edemann-Callesen H; Voget M; Empl L; Vogel M; Wieske F; Rummel J; Heinz A; Mathé AA; Hadar R; Winter C
Article: JOURNAL OF NEUROSCIENCE. 2015;35(11):4599-4613

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

Slattery DA; Naik RR; Grund T; Yen Y-C; Sartori SB; Füchsl A; Finger BC; Elfving B; Nordemann U; Guerrini R; Calo G; Wegener G; Mathé AA; Singewald N; Czibere L; Landgraf R; Neumann ID
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;281:348-357

Expression of inflammatory markers in a genetic rodent model of depression.

Strenn N; Suchankova P; Nilsson S; Fischer C; Wegener G; Mathé AA; Ekman A
Article: NEUROPSYCHOPHARMACOLOGY. 2015;40(3):774-790

Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times.

Cohen S; Vainer E; Matar MA; Kozlovsky N; Kaplan Z; Zohar J; Mathé AA; Cohen H
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(7):pyv002

Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium.

Wei YB; Backlund L; Wegener G; Mathé AA; Lavebratt C
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24(12):1907-1915

Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts.

Sandberg JV; Jakobsson J; Pålsson E; Landén M; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(1):pyu023

Cerebrospinal fluid neuropeptide Y levels in major depression and reported childhood trauma.

Soleimani L; Oquendo MA; Sullivan GM; Mathé AA; Mann JJ
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu067

Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways.

Mallei A; Failler M; Corna S; Racagni G; Mathé AA; Popoli M
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(2):pyu032

Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.

Wei Y; Melas PA; Wegener G; Mathé AA; Lavebratt C
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2014;28(10):964-972

Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration.

Croce N; Mathé AA; Gelfo F; Caltagirone C; Bernardini S; Angelucci F
Article: NEUROSCIENCE LETTERS. 2014;559:163-168

Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model.

Shrestha SS; Pine DS; Luckenbaugh DA; Varnäs K; Henter ID; Innis RB; Mathé AA; Svenningsson P
Article: BRAIN STIMULATION. 2014;7(1):21-28

Anti-anhedonic effect of deep brain stimulation of the prefrontal cortex and the dopaminergic reward system in a genetic rat model of depression: an intracranial self-stimulation paradigm study.

Rea E; Rummel J; Schmidt TT; Hadar R; Heinz A; Mathé AA; Winter C
Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e261

Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres.

Martinsson L; Wei Y; Xu D; Melas PA; Mathé AA; Schalling M; Lavebratt C; Backlund L
Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e255

Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.

Melas PA; Lennartsson A; Vakifahmetoglu-Norberg H; Wei Y; Åberg E; Werme M; Rogdaki M; Mannervik M; Wegener G; Brené S; Mathé AA; Lavebratt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(12):4804-4809

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

Nasca C; Xenos D; Barone Y; Caruso A; Scaccianoce S; Matrisciano F; Battaglia G; Mathé AA; Pittaluga A; Lionetto L; Simmaco M; Nicoletti F
Article: FRONTIERS IN PSYCHOLOGY. 2013;4:597

Maternal status regulates cortical responses to the body odor of newborns.

Lundström JN; Mathe A; Schaal B; Frasnelli J; Nitzsche K; Gerber J; Hummel T
Article: BIOLOGICAL PSYCHIATRY. 2012;72(12):997-1003

Cerebrospinal fluid neuropeptide Y-like immunoreactivity correlates with impulsive aggression in human subjects.

Coccaro EF; Lee R; Liu T; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(8):1051-1061

Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response.

Nikisch G; Baumann P; Liu T; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(5):669-679

Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression.

Melas PA; Rogdaki M; Lennartsson A; Björk K; Qi H; Witasp A; Werme M; Wegener G; Mathé AA; Svenningsson P; Lavebratt C
Article: PEPTIDES. 2012;35(1):49-55

Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model.

Melas PA; Mannervik M; Mathé AA; Lavebratt C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(3):375-387

Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression.

Wegener G; Finger BC; Elfving B; Keller K; Liebenberg N; Fischer CW; Singewald N; Slattery DA; Neumann ID; Mathé AA
Article: MOLECULAR PSYCHIATRY. 2012;17(2):173-184

Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration.

Eriksson TM; Delagrange P; Spedding M; Popoli M; Mathé AA; Ögren SO; Svenningsson P
Article: NEUROPSYCHOPHARMACOLOGY. 2012;37(2):350-363

The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder.

Cohen H; Liu T; Kozlovsky N; Kaplan Z; Zohar J; Mathé AA
Article: PSYCHONEUROENDOCRINOLOGY. 2012;37(1):78-86

The neuroendocrinology of childhood trauma in personality disorder.

Lee RJ; Hempel J; Tenharmsel A; Liu T; Mathé AA; Klock A
Article: PHARMACOGENETICS AND GENOMICS. 2011;21(12):779-789

Antidepressants and the resilience to early-life stress in inbred mouse strains.

Binder E; Malki K; Paya-Cano JL; Fernandes C; Aitchison KJ; Mathé AA; Sluyter F; Schalkwyk LC
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21(12):918-927

Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regions.

Gruber SHM; Angelucci F; Nomikos GG; Mathé AA
Article: NEUROPEPTIDES. 2011;45(6):401-406

Increased numbers of orexin/hypocretin neurons in a genetic rat depression model.

Mikrouli E; Wörtwein G; Soylu R; Mathé AA; Petersén Å
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2011;25(10):1378-1387

Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats.

Hansson AC; Rimondini R; Heilig M; Mathé AA; Sommer WH
Article: BEHAVIOURAL BRAIN RESEARCH. 2011;221(1):43-49

Impact of early life stress on alcohol consumption and on the short- and long-term responses to alcohol in adolescent female rats.

Van Waes V; Darnaudéry M; Marrocco J; Gruber SH; Talavera E; Mairesse J; Van Camp G; Casolla B; Nicoletti F; Mathé AA; Maccari S; Morley-Fletcher S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(6):796-833

Escitalopram modulates neuron-remodelling proteins in a rat gene-environment interaction model of depression as revealed by proteomics. Part I: genetic background.

Piubelli C; Vighini M; Mathé AA; Domenici E; Carboni L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(6):834-855

Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene-environment interaction model of depression as revealed by proteomics. Part II: environmental challenge.

Piubelli C; Vighini M; Mathé AA; Domenici E; Carboni L
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2011;99(1):104-111

Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats.

Criado JR; Liu T; Ehlers CL; Mathé AA
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(8):1769-1777

Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression.

Hascup KN; Hascup ER; Stephens ML; Glaser PEA; Yoshitake T; Mathé AA; Gerhardt GA; Kehr J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21(7):545-562

Nortriptyline influences protein pathways involved in carbohydrate metabolism and actin-related processes in a rat gene-environment model of depression.

Piubelli C; Gruber S; El Khoury A; Mathé AA; Domenici E; Carboni L
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2011;25(7):896-907

Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study.

Nikisch G; Baumann P; Oneda B; Kiessling B; Weisser H; Mathé AA; Yoshitake T; Kehr J; Wiedemann G; Eap CB
Article: NEUROPHARMACOLOGY. 2011;60(7-8):1243-1253

Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response.

Mallei A; Giambelli R; Gass P; Racagni G; Mathé AA; Vollmayr B; Popoli M
Article: NEUROSCIENCE. 2011;176:349-380

Regulation of cytoskeleton machinery, neurogenesis and energy metabolism pathways in a rat gene-environment model of depression revealed by proteomic analysis.

Piubelli C; Carboni L; Becchi S; Mathé AA; Domenici E
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2010;30(5):496-503

Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF.

Nikisch G; Baumann P; Wiedemann G; Kiessling B; Weisser H; Hertel A; Yoshitake T; Kehr J; Mathé AA
Article: PLOS ONE. 2010;5(9):e12596

Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.

Blaveri E; Kelly F; Mallei A; Harris K; Taylor A; Reid J; Razzoli M; Carboni L; Piubelli C; Musazzi L; Racagni G; Mathé A; Popoli M; Domenici E; Bates S
Article: ALCOHOL. 2010;44(6):487-493

Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains.

Walker BM; Drimmer DA; Walker JL; Liu T; Mathé AA; Ehlers CL
Article: HIPPOCAMPUS. 2010;20(7):820-828

The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression.

Bjørnebekk A; Mathé AA; Brené S
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2010;44(8):511-520

Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression.

Musazzi L; Mallei A; Tardito D; Gruber SHM; El Khoury A; Racagni G; Mathé AA; Popoli M
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(5):563-572

Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression.

Elfving B; Plougmann PH; Müller HK; Mathé AA; Rosenberg R; Wegener G
Article: BRAIN RESEARCH. 2010;1325:112-120

Enhanced expression of the neuronal K+/Cl- cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats.

Matrisciano F; Nasca C; Molinaro G; Riozzi B; Scaccianoce S; Raggi MA; Mercolini L; Biagioni F; Mathè AA; Sanna E; Maciocco E; Pignatelli M; Biggio G; Nicoletti F
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20(1):18-24

CSF neurochemicals during tryptophan depletion in individuals with remitted depression and healthy controls.

Moreno FA; Parkinson D; Palmer C; Castro WL; Misiaszek J; El Khoury A; Mathé AA; Wright R; Delgado PL
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):553-559

Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression.

Ryan B; Musazzi L; Mallei A; Tardito D; Gruber SHM; El Khoury A; Anwyl R; Racagni G; Mathé AA; Rowan MJ; Popoli M
Article: NEUROBIOLOGY OF DISEASE. 2009;34(2):375-380

Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety.

Wiehager S; Beiderbeck DI; Gruber SHM; El-Khoury A; Wamsteeker J; Neumann ID; Petersén A; Mathé AA
Article: NEUROSCIENCE LETTERS. 2009;451(2):148-151

Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model.

Petersén A; Wörtwein G; Gruber SHM; El-Khoury A; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(8):1135-1147

Housing conditions modulate escitalopram effects on antidepressive-like behaviour and brain neurochemistry.

Bjørnebekk A; Mathé AA; Gruber SHM; Brené S
Article: NEUROPEPTIDES. 2008;42(5-6):535-541

Differential effects of olanzapine, haloperidol and risperidone on calcitonin gene-related peptide in the rat brain.

Angelucci F; Gruber SHM; Caltagirone C; Mathé AA
Article: NEUROPHARMACOLOGY. 2008;55(4):525-531

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.

Matrisciano F; Caruso A; Orlando R; Marchiafava M; Bruno V; Battaglia G; Gruber SHM; Melchiorri D; Tatarelli R; Girardi P; Mathè AA; Nicoletti F
Article: EUROPEAN PSYCHIATRY. 2008;23(5):356-359

CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy.

Nikisch G; Mathé AA
Article: NEUROSCIENCE LETTERS. 2008;436(3):305-308

Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model.

Petersén A; Wörtwein G; Gruber SHM; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(1):93-101

Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression: implications for the pathophysiology of depression.

Husum H; Wörtwein G; Andersson W; Bolwig TG; Mathé AA
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(12):756-762

Chronic amphetamine treatment reduces NGF and BDNF in the rat brain.

Angelucci F; Gruber SHM; El Khoury A; Tonali PA; Mathé AA
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2007;21(8):820-825

Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor.

Angelucci F; Ricci V; Pomponi M; Conte G; Mathé AA; Attilio Tonali P; Bria P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2007;10(5):609-619

Restraint stress influences AP-1 and CREB DNA-binding activity induced by chronic lithium treatment in the rat frontal cortex and hippocampus.

Miller JC; Jiménez P; Mathé AA
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):226-231

Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?

Mathé AA; Husum H; El Khoury A; Jiménez-Vasquez P; Gruber SHM; Wörtwein G; Nikisch G; Baumann P; Agren H; Andersson W; Södergren A; Angelucci F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):136-140

Running is rewarding and antidepressive.

Brené S; Bjørnebekk A; Aberg E; Mathé AA; Olson L; Werme M
Article: NEUROREPORT. 2007;18(10):1039-1043

Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA.

Bjørnebekk A; Mathé AA; Brené S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(4):298-308

Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression.

Jiménez-Vasquez PA; Diaz-Cabiale Z; Caberlotto L; Bellido I; Overstreet D; Fuxe K; Mathé AA
Article: BRAIN RESEARCH. 2007;1131(1):181-186

Impact of an intense stress on ethanol consumption in female rats characterized by their pre-stress preference: modulation by prenatal stress.

Darnaudéry M; Louvart H; Defrance L; Léonhardt M; Morley-Fletcher S; Gruber SH; Galietta G; Mathé AA; Maccari S
Article: HIPPOCAMPUS. 2007;17(12):1193-1200

Social isolation increases number of newly proliferated cells in hippocampus in female flinders sensitive line rats.

Bjørnebekk A; Mathé AA; Gruber SHM; Brené S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16(8):592-600

Effects of acute and subchronic d-amphetamine on ventral striatal concentrations of neurotensin and neuropeptide Y in rats treated with antipsychotic drugs.

Gruber SHM; Nomikos GG; Mathé AA
Article: PEPTIDES. 2006;27(12):3202-3207

Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze.

Bacchi F; Mathé AA; Jiménez P; Stasi L; Arban R; Gerrard P; Caberlotto L
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2006;84(6):1292-1302

Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line "depressed" rat: Implications for the pathophysiology of depression?

Husum H; Aznar S; Høyer-Hansen S; Larsen MH; Mikkelsen JD; Møller A; Mathé AA; Wörtwein G
Article: NEUROPSYCHOPHARMACOLOGY. 2006;31(2):256-264

Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls.

Bjørnebekk A; Mathé AA; Brené S
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2006;83(1):28-34

The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats.

Thorsell A; Slawecki CJ; El Khoury A; Mathe AA; Ehlers CL
Article: PSYCHOPHARMACOLOGY. 2005;181(4):751-760

Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response.

Nikisch G; Mathé AA; Czernik A; Thiele J; Bohner J; Eap CB; Agren H; Baumann P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):357-368

The antidepressant effect of running is associated with increased hippocampal cell proliferation.

Bjørnebekk A; Mathé AA; Brené S
Article: NEUROPEPTIDES. 2005;39(4):369-377

Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behavior.

Slawecki CJ; Thorsell AK; El Khoury A; Mathé AA; Ehlers CL
Article: ALCOHOL. 2005;36(2):91-97

Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats.

Thorsell A; Slawecki CJ; Khoury A; Mathe AA; Ehlers CL
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15(3):311-317

Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain.

Angelucci F; Aloe L; Iannitelli A; Gruber SHM; Mathé AA
Article: PSYCHOPHARMACOLOGY. 2005;178(2-3):115-124

Neuropeptide expression in rats exposed to chronic mild stresses.

Sergeyev V; Fetissov S; Mathé AA; Jimenez PA; Bartfai T; Mortas P; Gaudet L; Moreau J-L; Hökfelt T
Article: JOURNAL OF STUDIES ON ALCOHOL AND DRUGS. 2005;66(1):46-52

Effect of ethanol on brain neuropeptides in adolescent and adult rats.

Slawecki CJ; Jiménez-Vasquez P; Mathé AA; Ehlers CL
Article: PSYCHOPHARMAKOTHERAPIE. 2005;12(4):130-134

Citalopram plasma and cerebrospinal fluid (CSF) concentrations monitoring:: Relationship with CSF monoamine metabolites and clinical outcomes

Nikisch G; Mathé AA; Baumann P
Article: EPILEPSY & BEHAVIOR. 2004;5(2):204-215

Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties.

Husum H; Bolwig TG; Sánchez C; Mathé AA; Hansen SL
Article: NEUROPSYCHOBIOLOGY. 2004;50(3):239-243

Neuropeptide y in euthymic lithium-treated women with bipolar disorder.

El Khoury A; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2003;6(3):225-231

Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression.

Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: NEUROPSYCHOPHARMACOLOGY. 2003;28(7):1292-1299

Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects.

Husum H; Van Kammen D; Termeer E; Bolwig G; Mathé A
Article: BIPOLAR DISORDERS. 2003;5(2):129-137

Social support in bipolar disorder: its relevance to remission and relapse.

Johnson L; Lundström O; Aberg-Wistedt A; Mathé AA
Article: JOURNAL OF NEUROCHEMISTRY. 2003;85(2):462-468

Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice.

McNamara RK; Vasquez PA; Mathe AA; Lenox RH
Article: NEUROPEPTIDES. 2003;37(1):51-56

Electroconvulsive stimuli alter nerve growth factor but not brain-derived neurotrophic factor concentrations in brains of a rat model of depression.

Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(2):378-381

Identification of the bioactive peptide PEC-60 in brain.

Norberg A; Gruber S; Angelucci F; Renlund S; Wadensten H; Efendic S; Ostenson CG; Jörnvall H; Sillard R; Mathé AA
Article: NEUROPSYCHOBIOLOGY. 2003;48(1):14-18

Decreased plasma prolactin release in euthymic lithium-treated women with bipolar disorder.

El Khoury A; Tham A; Mathé AA; Aberg-Wistedt A; Stain-Malmgren R
Article: NEUROPSYCHOPHARMACOLOGY. 2002;27(5):756-764

Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes.

Husum H; Mathé AA
Article: NEUROPEPTIDES. 2002;36(5):363-369

Extracellular levels of NPY in the dorsal hippocampus of freely moving rats are markedly elevated following a single electroconvulsive stimulation, irrespective of anticonvulsive Y1 receptor blockade.

Husum H; Gruber SHM; Bolwig TG; Mathé AA
Article: JOURNAL OF ECT. 2002;18(3):138-143

Electroconvulsive stimuli alter the regional concentrations of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in adult rat brain.

Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(1):133-139

d-Amphetamine-induced increase in neurotensin and neuropeptide Y outflow in the ventral striatum is mediated via stimulation of dopamine D1 and D2/3 receptors.

Gruber SHM; Nomikos GG; Mathé AA
Article: NEUROPHARMACOLOGY. 2002;42(6):798-806

Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats.

Husum H; Termeer E; Mathé AA; Bolwig TG; Ellenbroek BA
Article: NEUROPSYCHOPHARMACOLOGY. 2002;26(5):595-604

Effects of haloperidol and risperidone on neurotensin levels in brain regions and neurotensin efflux in the ventral striatum of the rat.

Gruber SHM; Nomikos GG; Mathé AA
Article: NEUROSCIENCE LETTERS. 2002;317(2):101-105

Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression.

Bellido I; Díaz-Cabiale Z; Jiménez-Vasquez PA; Andbjer B; Mathé AA; Fuxe K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2001;4(4):329-336

Tryptophan depletion in lithium-stabilized patients with affective disorder.

Johnson L; El-Khoury A; Aberg-Wistedt A; Stain-Malmgren R; Mathé AA
Article: DEVELOPMENTAL BRAIN RESEARCH. 2001;131(1-2):149-152

Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats.

Jiménez-Vasquez PA; Mathé AA; Thomas JD; Riley EP; Ehlers CL
Article: JOURNAL OF STUDIES ON ALCOHOL AND DRUGS. 2001;62(6):736-740

Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats.

Slawecki CJ; Jimenéz-Vasquez P; Mathé AA; Ehlers CL
Article: NEUROPEPTIDES. 2001;35(5-6):285-291

A pilot study of rat brain regional distribution of calcitonin, katacalcin and calcitonin gene-related peptide before and after antipsychotic treatment.

Angelucci F; Gruber SH; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;64(6):606-611

Dopamine receptor antagonists prevent the d-amphetamine-induced increase in calcitonin gene-related peptide levels in ventral striatum.

Gruber SH; Nomikos GG; Mathé AA
Article: NEUROPEPTIDES. 2001;35(3-4):168-173

Neuropeptide Y (NPY) mRNA in rat brain tissue: effects of decapitation and high-energy microwave irradiation on post mortem stability.

Thorsell A; Gruber SH; Mathé AA; Heilig M
Article: NEUROPSYCHOPHARMACOLOGY. 2001;24(2):183-191

Changed concentrations of tachykinins and neuropeptide Y in brain of a rat model of depression: lithium treatment normalizes tachykinins.

Husum H; Vasquez PA; Mathé AA
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2000;10(6):495-500

Effects of acute and chronic electroconvulsive stimuli on cAMP and cGMP efflux in the rat striatum and hippocampus.

Nomikos GG; Gruber S; Svensson TH; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2000;3(4):277-283

Tryptophan depletion selectively reduces CSF 5-HT metabolites in healthy young men: results from single lumbar puncture sampling technique.

Moreno FA; McGavin C; Malan TP; Gelenberg AJ; Heninger GR; Mathé AA; Delgado PL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(23):12852-12857

Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.

Thorsell A; Michalkiewicz M; Dumont Y; Quirion R; Caberlotto L; Rimondini R; Mathé AA; Heilig M
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2000;34(6):405-412

Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effects of electroconvulsive stimuli.

Jiménez-Vasquez PA; Overstreet DH; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;61(4):458-463

Effects of typical and atypical antipsychotics on neuropeptide Y in rat brain tissue and microdialysates from ventral striatum.

Gruber SH; Mathé AA
Article: JOURNAL OF AFFECTIVE DISORDERS. 2000;59(2):139-148

Age of onset in affective disorder: its correlation with hereditary and psychosocial factors.

Johnson L; Andersson-Lundman G; Aberg-Wistedt A; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;60(6):783-794

Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration.

Angelucci F; Mathé AA; Aloe L
Article: BEHAVIOURAL BRAIN RESEARCH. 2000;111(1-2):115-123

Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion.

Jiménez Vasquez PA; Salmi P; Ahlenius S; Mathé AA
Article: NEUROPHARMACOLOGY. 2000;39(8):1463-1473

Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram.

Husum H; Mikkelsen JD; Hogg S; Mathé AA; Mørk A
Article: NEUROREPORT. 2000;11(6):1369-1373

Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression.

Angelucci F; Aloe L; Vasquez PJ; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 1999;2(3):173-179

Calcitonin gene-related peptide (CGRP) levels and alcohol.

Ehlers CL; Somes C; Li T-K; Lumeng L; Hwang BH; Jimenez P; Mathé AA
Article: NEUROSCIENCE LETTERS. 1999;265(3):191-194

Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression.

Caberlotto L; Jimenez P; Overstreet DH; Hurd YL; Mathé AA; Fuxe K
Article: BIOLOGICAL PSYCHIATRY. 1999;45(3):285-289

Venlafaxine but not bupropion decreases cerebrospinal fluid 5-hydroxyindoleacetic acid in unipolar depression.

Little JT; Ketter TA; Mathé AA; Frye MA; Luckenbaugh D; Post RM
Article: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 1998;22(8):1778-1782

Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure.

Ehlers CL; Li TK; Lumeng L; Hwang BH; Somes C; Jimenez P; Mathé AA
Article: ACTA PSYCHIATRICA SCANDINAVICA. 1998;97(5):374-380

Serotonergic 'vulnerability' in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram-responders.

Aberg-Wistedt A; Hasselmark L; Stain-Malmgren R; Apéria B; Kjellman BF; Mathé AA
Article: NEUROPEPTIDES. 1997;31(4):357-365

A comparison between microwave irradiation and decapitation: basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides.

Nylander I; Stenfors C; Tan-No K; Mathé AA; Terenius L
Article: NEUROPSYCHOPHARMACOLOGY. 1997;16(6):408-418

Basal and stimulated C-fos mRNA expression in the rat brain: effect of chronic dietary lithium.

Miller JC; Mathé AA
Article: NEUROCHEMICAL RESEARCH. 1997;22(5):629-636

Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain.

Mathé AA; Gruber S; Jiménez PA; Theodorsson E; Stenfors C
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;319(2-3):191-195

Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific region of the rat striatum after electroconvulsive stimuli.

Zachrisson O; Mathé AA; Lindefors N
Article: JOURNAL OF CLINICAL PSYCHIATRY. 1997;58(1):26-29

Impaired neuropsychological performance in euthymic patients with recurring mood disorders.

Tham A; Engelbrektson K; Mathé AA; Johnson L; Olsson E; Aberg-Wistedt A
Article: BRAIN RESEARCH. 1996;43(1-2):347-350

Effects of chronic lithium and electroconvulsive stimuli on cholecystokinin mRNA expression in the rat brain.

Zachrisson O; Mathé AA; Lindefors N
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1996;46(3):316-323

The psychotomimetic drugs D-amphetamine and phencyclidine release calcitonin gene-related peptide in the limbic forebrain of the rat.

Mathé AA; Hertel P; Nomikos GG; Gruber S; Mathé JM; Svensson TH
Article: BRAIN RESEARCH. 1995;698(1-2):39-45

Concurrent analysis of neuropeptides and biogenic amines in brain tissue of rats treated with electroconvulsive stimuli.

Stenfors C; Bjellerup P; Mathé AA; Theodorsson E
Article: PSYCHOLOGICAL MEDICINE. 1995;25(5):1037-1049

A twin study of generalized anxiety disorder and major depression.

Roy MA; Neale MC; Pedersen NL; Mathé AA; Kendler KS
Article: NEUROSCIENCE LETTERS. 1995;194(1-2):89-92

Region-specific effects of chronic lithium administration on neuropeptide Y and somatostatin mRNA expression in the rat brain.

Zachrisson O; Mathé AA; Stenfors C; Lindefors N
Article: ACTA PSYCHIATRICA SCANDINAVICA. 1995;92(1):51-55

Seasonal mood variation among Japanese residents of Stockholm.

Murase S; Murase S; Kitabatake M; Yamauchi T; Mathé AA
Article: BRAIN RESEARCH. 1995;31(1-2):71-85

Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain.

Zachrisson O; Mathé AA; Stenfors C; Lindefors N
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1995;41(2):206-212

Chromatographic and immunochemical characterization of rat brain neuropeptide Y-like immunoreactivity (NPY-LI) following repeated electroconvulsive stimuli.

Stenfors C; Mathé AA; Theodorsson E
Article: BEHAVIOR GENETICS. 1995;25(3):217-232

A pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: results of model fitting.

Kendler KS; Pedersen NL; Neale MC; Mathé AA
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All other publications

Other: NEUROPSYCHOPHARMACOLOGY. 2020;45(11):1960

Torgny Svensson, M.D., Ph.D. (1945-2020).

Aghajanian GK; Mathé AA; Eriksson E; Krystal JH
Review: FRONTIERS IN ENDOCRINOLOGY. 2017;8:178

Neuropeptide Y in Alcohol Addiction and Affective Disorders.

Thorsell A; Mathé AA
Review: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2014;92(8):621-630

The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease.

Angelucci F; Gelfo F; Fiore M; Croce N; Mathé AA; Bernardini S; Caltagirone C
Review: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2013;7:10

Understanding resilience.

Wu G; Feder A; Cohen H; Kim JJ; Calderon S; Charney DS; Mathé AA
Corrigendum: JOURNAL OF PSYCHIATRIC RESEARCH. 2012;46(8):1108

Retraction notice to “Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine” [J Psychiat Res 44 (2010) 754e759].
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2011;15(11):1317-1331

Central functions of neuropeptide Y in mood and anxiety disorders.

Wu G; Feder A; Wegener G; Bailey C; Saxena S; Charney D; Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2011;35(6):1357-1375

Animal models of depression and anxiety: What do they tell us about human condition?

Neumann ID; Wegener G; Homberg JR; Cohen H; Slattery DA; Zohar J; Olivier JDA; Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2010;34(6):1037-1048

Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression.

Carboni L; Becchi S; Piubelli C; Mallei A; Giambelli R; Razzoli M; Mathé AA; Popoli M; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S186

Potential therapeutic targets from cellular/molecular signalling mechanisms in depression models

Svenningsson P; Eriksson TM; Bjork K; Ogren SO; Mathe A; El Yacoubi M; Vaugeois JM
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S479

Neuropeptide S alters depression- and anxiety-like behaviors in the FSL/FRL rats, a genetic animal model of depression

Wegener G; Finger BC; Slattery DA; Neumann ID; Mathe AA
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S398

Social isolation and "depressed" Flinders Sensitive Line rats: behaviour, steroids, and neuronal plasticity markers

Bianchi M; Ladurelle N; Liere P; Pianos A; Mathe AA; Baulieu EE
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S41-S42

Neuropeptide Y modulation of the glutamatergic system in the Flinders Sensitive Line rat: a rat model of depression

Hascup KN; Hascup ER; Gerhardt GA; Mathe AA; Kehr J
Review: EFFECTS OF PERI-ADOLESCENT LICIT AND ILLICIT DRUG USE ON THE DEVELOPING CNS, PT II. 2009;88:1-24

Effects of psychostimulants on neurotrophins implications for psychostimulant-induced neurotoxicity.

Angelucci F; Ricci V; Spalletta G; Caltagirone C; Mathé AA; Bria P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S355-S356

Proteome changes in rat hippocampus and pre-frontal/frontal cortex in Flinders rats after nortriptyline treatment

Carboni L; Piubelli C; De Luca M; Gruber S; Andersson W; El Khoury A; Mathe AA; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S355

Proteome changes in rat hippocampus and pre-frontal/frontal cortex in Flinders rats after escitalopram treatment

Piubelli C; Becchi S; El Khoury A; Andersson W; Gruber S; Mathe AA; Domenici E; Carboni L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S323

Hippocampal cytogenesis is increased in a genetic rat model of depression. Escitalopram reduces increased cell number

Mathe A; Gruber SHM; Wortwein G; Petersen A
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S254

Effects of maternal separation and antidepressant treatment on adult brain and behavior in a rat model of depression

El Khoury A; Werme M; Gruber SHM; Mathe AA
Letter: HARVARD REVIEW OF PSYCHIATRY. 2008;16(4):267

Ecological studies of antidepressant treatment and suicidal risks.

Isacsson G; Mathé A
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2008;32(3):651-661

Acute stress differentially affects corticotropin-releasing hormone mRNA expression in the central amygdala of the "depressed" flinders sensitive line and the control flinders resistant line rats.

Zambello E; Jiménez-Vasquez PA; El Khoury A; Mathé AA; Caberlotto L
Meeting abstract: EUROPEAN PSYCHIATRY. 2008;23:S2

Gene-environment interaction in an animal model of depression

Mathe AA; El Khoury A; Gruber SH
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S19-S20

Synaptoproteomic analysis of a rat model of depression with gene-environment interaction

Mallei A; Giambelli R; Barbiero VS; Musazzi L; El Khoury A; Gruber SH; Mathe AA; Racagni G; Popoli M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S510-S511

Brain biochemistry markers differentiate between animal models of anxiety and depression

Mathe AA; Gruber SHM; El Khoury A; Beiderbeck D; Neumann ID; Landgraf R
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S213

Gene-environment interaction in a genetic rat model of depression

Mathe A; El Khoury A; Gruber SHM; Sodergren A; Jimenez P; Husum H; Wortwein G
Letter: MOLECULAR PSYCHIATRY. 2007;12(8):704-706

Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?

Matrisciano F; Panaccione I; Zusso M; Giusti P; Tatarelli R; Iacovelli L; Mathé AA; Gruber SHM; Nicoletti F; Girardi P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S24

Functional and molecular correlates of synaptic plasticity in a gene -: environment combination rat model of depression

Musazzi L; Barbiero V; Mallei A; Mathe A; El Khoury A; Gruber SH; Racagni G; Ryan BK; Rowan MJ; Popoli M
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2006;30(4):684-693

Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions.

Wörtwein G; Husum H; Andersson W; Bolwig TG; Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2006;30(3):535-540

Adult life behavioral consequences of early maternal separation are alleviated by escitalopram treatment in a rat model of depression.

El Khoury A; Gruber SHM; Mørk A; Mathé AA
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S20-S21

Functional proteomic analysis of an animal model of depression combining genetic vulnerability and environmental stress

Mallei A; Giambelli R; Barbiero VS; Maglione M; Mathé AA; El Khoury A; Carboni L; Domenici E; Racagni G; Popoli M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S336-S337

Proteomic analysis of hippocampus and frontal cortex in a rat model of depression with gene-environment interaction and antidepressant treatment

Carboni L; Piubelli C; Vighini M; El Khoury A; Gruber S; Anderssen W; Mathe AA; Aitchison KJ; Mallei A; Giambelli R; Popoli M; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S308-S309

Neuropeptides in human cerebrospinal fluid and in brains of animal models of depression -: effects of treatment

Mathe AA; Nikisch G; Agren H; Baumann P; El Khoury A; Gruber SHM; Husum H; Jimenez-Vasquez P; Wortwein G; Andersson W; Aitchison KJ; McGuffin P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S169-S170

Functional proteomic analysis of an animal model of depression combining genetic vulnerability and environmental stress

Mallei A; Giambelli R; Barbiero VS; Mathe AA; El Khoury A; Carboni L; Domenici E; Aitchison KJ; Racagni G; Popoli M
Published conference paper: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):403-410

Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram.

Nikisch G; Agren H; Eap CB; Czernik A; Baumann P; Mathé AA
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2005;29(4-5):739-759

The Flinders Sensitive Line rat: a selectively bred putative animal model of depression.

Overstreet DH; Friedman E; Mathé AA; Yadid G
Review: MOLECULAR PSYCHIATRY. 2005;10(4):345-352

BDNF in schizophrenia, depression and corresponding animal models.

Angelucci F; Brenè S; Mathé AA
Published conference paper: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2004;24(3):283-290

Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response.

Nikisch G; Mathé AA; Czernik A; Eap CB; Jiménez-Vasquez P; Brawand-Amey M; Baumann P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2004;14:S3

The role of neurogenesis in addiction and depression

Brené S; Åberg E; Bjornebekk A; Hofstetter C; Mathè AA; Olson L
Review: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 2004;146:151-165

Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia.

Angelucci F; Mathé AA; Aloe L
Letter: BIOLOGICAL PSYCHIATRY. 2003;53(3):268-270

Comment on "preclinical models: status of basic research in depression".

Overstreet DH; Daws LC; Yadid G; Friedman E; Mathé AA; Janowsky DS
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2002;26(1):41-48

Calcitonin gene-related peptide and calcitonin in the CSF of patients with dementia and depression: possible disease markers.

Mathé AA; Agren H; Wallin A; Blennow K
Review: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2000;3(1):13-25

Chronic antipsychotic treatment selectively alters nerve growth factor and neuropeptide Y immunoreactivity and the distribution of choline acetyl transferase in rat brain regions.

Angelucci F; Aloe L; Gruber SHM; Fiore M; Mathé AA
Review: JOURNAL OF ECT. 1999;15(1):60-75

Neuropeptides and electroconvulsive treatment.

Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1998;22(6):1007-1021

Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain.

Marteinsdottir I; Horrobin DF; Stenfors C; Theodorsson E; Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1998;22(3):529-546

Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded "depressed", Wistar, and Sprague Dawley rats. Effects of electroconvulsive stimuli.

Mathé AA; Jimenez PA; Theodorsson E; Stenfors C
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1998;43:42S

Deficits in neuropeptide Y in a genetic animal model of depression are normalized by chronic fluoxetine treatment

Caberlotto L; Hurd Y; Fuxe K; Mathe AA; Overstreet DH
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1998;43:s102

CSF neuropeptide Y correlates with anxiety in patients with affective disorders

Osuch EA; Frye MA; Little JT; Kimbrell TA; Huggins T; Dunn R; Speer A; Cora-Locatelli G; Vanderham L; Post RM; Mathe AA
Published conference paper: BEHAVIOURAL BRAIN RESEARCH. 1995;72(1-2):103-114

Effects of D-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat.

Hertel P; Mathé JM; Nomikos GG; Iurlo M; Mathé AA; Svensson TH
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1995;19(7):1177-1187

Chronic dietary lithium inhibits basal c-fos mRNA expression in rat brain.

Mathé AA; Miller JC; Stenfors C
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):654

ELEVATED CONCENTRATIONS OF CSF CGRP MIGHT BE A TRAIT MARKER FOR AFFECTIVE-ILLNESS

MATHE AA; GEORGE MS; FRYE MA; POST RM
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):610

CSF CGRP CORRELATES WITH NEUROPEPTIDES IN CONTROLS BUT NOT AFFECTIVE-ILLNESS

GEORGE MS; MATHE AA; FRYE MA; DAVIS CL; PAZZAGLIA PJ; RUBINOW DL; JERRELS S; POST RM
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):609-610

CSF NEUROPEPTIDE-Y IN MOOD DISORDERS AND TREATMENT WITH CARBAMAZEPINE

FRYE MA; MATHE AA; GEORGE MS; PAZZAGLIA PJ; JERRELS S; POST RM
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1995;19(2):323-332

EFFECTS OF ACUTE AND CHRONIC ELECTROCONVULSIVE TREATMENT ON INTERSTITIAL CONCENTRATIONS OF SOMATOSTATIN IN THE RAT HIPPOCAMPUS AND STRIATUM

MATHE AA; NOMIKOS GG; SVENSSON TH
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Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2021-2024

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Docent, Karolinska Institutet, 1984

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