Research Group - Zhu Jie
Neuroinflammation and Neuroimmunity
We aim to investigate the role of inflammatory molecules, especially for cytokines and chemokines, as well as ApoE molecules in neuroinflammatory and neurodegenerative disorders and find new targets derived from experimental studies into clinical trial in such human diseases.
The neuroinflammation and neuroimmunity group is dedicated to investigation of the pathogenesis and treatment of neurodegenerative and neuroimmune diseases, including Alzheimer´s disease (AD), Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) and multiple sclerosis (MS), etc. The diseases represent some of the most common neurological diseases in the Western World, and constitute a tremendous burden to health budgets worldwide. Although the cause and mechanisms of neurodegenerative and neuroimmune diseases are unknown, inflammatory molecules and immune response, such as cytokines and chemikines as well as activated immune cells are involved in the pathogenesis of these disorders, since anti-inflammative substances and immuneregulators can slowdown the disease process clearly.
Currently we conduct the research programmes to get the knowledge for exploiting the pathogenesis of these disorders and apply in clinical patients. The aims of the project are as:
- To study the mechanisms underlying excitotoxic hippocampal neurodegeneration, focus on the role of immune cells and cytokines/chemokines in the neurodegeneration as well as ageing process and gender differences
- To investigate the role of inflammatory molecules and apoE in the pathogenesis of inflammatory autoimmune diseases in nervous system
- To develop novel therapies to treat neurodegenerative and neuroinflammatory diseases
Another important aim is the training of PhD students and postdoctoral fellows. We organize courses for the undergraduate students on immune, inflammation and Neuroscience. The research laboratory is located in the Novum at the Huddinge Hospital. We collaborate with research groups in CMM in Karolinska Hospital, Depts. of Infections immune and Clinical immunology in Huddinge Hospital and other disciplines. We also collaborate with several international research groups and with several international pharmaceutical companies.
|Phone:||+46-(0)8-585 854 94|
|Fax:||+46-(0)8-585 854 70|
|Address:||Karolinska Institutet |
Department of Neurobiology, Care Sciences and Society
Division of Neurodegeneration
Novum floor 5
141 57 Huddinge