Joana Pereiras researchgroup
Brain Connectomics Lab
Our group is working with brain connectivity measures derived from structural MRI, functional MRI and diffusion tensor imaging in patients with Alzheimer's disease and Parkinson's disease.
Our current projects are focused on the assessment of brain connectivity and network topology in different stages of these disorders as well as their relationship with clinical measures.
We also work with analyses of spatial patterns derived from amyloid and tau positron emission tomography as well as biomarkers derived from the cerebrospinal fluid and plasma.
Our ultimate goal is to develop new brain connectivity measures and graph theoretical approaches to improve the early diagnosis, assessment of disease progression and treatment of neurodegenerative diseases.
Research group leader
Multilayer brain connectivity
In this project, we are integrating the information from different neuroimaging modalities (DTI, fMRI, PET, T1-w) into a single brain connectome in order to assess the interaction between different pathological processes occurring in aging and neurodegenerative diseases.
Dynamic brain connectivity
In this project, we have developed new methods to assess dynamic changes in brain connectivity based on introducing delays in the correlations in the functional activation signals between brain areas. These methods have proven to be more sensitive to changes occurring in the networks of patients with Parkinson’s disease and Alzheimer’s disease compared to other dynamic connectivity measures.
Application of deep learning to brain connectivity measures
In this project, we are working with different types of neural network architectures to predict Alzheimer’s disease and other disorders from DTI and fMRI connectivity measures and topological properties.
Together with Prof. Giovanni Volpe (Department of Physics, University of Gothenburg) we have developed an open-access software for the analyses of brain connectivity: BRAPH (Brain Analysis with Graph Theory), which can be downloaded at: http://braph.org/. We are currently working on the second version of the software, which will include several major updates.
• Marie Curie Intra-European Fellowship (IEF)
• Swedish Research Council
• Centrum för innovativ medicin (CIMED)
• Loo och Hans Ostermans stiftelse
• Gamla Tjänarinnor
• Lindhes Advokatbyra AB
• KI Stiftelser
• Swedish Foundation for Strategic Research (SSF)
• Senior Research Faculty Position at Karolinska Institute