Jan Johansson group
Protein biochemistry for medical applications
Three major research lines are pursued; one concerns the BRICHOS domain for treatment of protein aggregation diseases, another line concerns development of synthetic surfactant for treatment of lung diseases and the third line focuses on molecular biology of spider silk proteins. Current activities include elucidation of the BRICHOS mechanism of action using a combination of structural biology, fibrillation kinetics, structure-function analyses, BRICHOS treatment of Alzheimer knock-in mouse models, a clinical trial of the first synthetic surfactant based on designed analogues of surfactant proteins SP-B and SP-C, studies of new surfactant protein analogues, and structure-function analyses of recombinant spider silk proteins.
Department of Neurobiology, Care Sciences and Society Neurobiologi, vårdvetenskap och samhälle (NVS)
Division of Neurogeriatrics
141 52 HUDDINGE