Biophysics and structural biology of protein missfolding
The major research line in my lab is spectroscopic and biophysical studies of amyloids to elucidate structure, function and assemblies. The current focus is on the Amyloid-β peptide but we also study other neuropathological associated peptides and amyloids such as α-synuclein, Huntingtin and IAPP. The main techniques we use is NMR. Thioflavin T fluorescence, CD-spectroscopy and analytical SEC. To study amyloids, we have come up with a novel recombinant production procedure, far superior previous systems described in the literature in terms of yield, purity and easiness. I work in close collaboration with professor Jens Pahnke at University of Oslo and professor Baiba Jansone at Lativan University were our findings guide their in vivo experiments in transgenic mice. Together with Professor Jan Johansson we also study structural features of the Bri2 BRICHOS domain.
I am currently seeking highly motivated master and bachelor students for exciting projects in the field of neurodegeneration diseases with main focus of structural biology and biophysics. Please e-mail CV to email@example.com for descriptions of available projects.
Department of Neurobiology, Care Sciences and Society Neurobiologi, vårdvetenskap och samhälle (NVS)
Division of Neurogeriatrics
141 52 HUDDINGE