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Cascade is a newly developed software for segmenting white matter lesions automatically.

The program is freely accessible, and a link or other instructions how to get access to it will follow.

CASCADE segments white matter lesions (WML) and estimates the total WML load. Input-images are any combination of T1-weighted, T2-weighted, PD and FLAIR images. CASCADE is a very good tool, not only for its accuracy and robustness, but also because it can easily produce results without any restriction on image input.


CASCADE, was developed and is continuously updated at the Division of Clinical Geriatrics, Karolinska Institutet. It is now being used by researchers worldwide, including Sweden, Finland, Norway, the Netherlands, England, Spain and Canada.


Download the latest version here.

If you are using CASCADE in your research, please reference:


Damangir, Soheil, et al. "Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines." Journal of the neurological sciences 322.1 (2012): 211-216.


For any inquiries about CASCADE, please contact Soheil Damangir at:



Department of neurobiology, care sciences and society (NVS)|

Karolinska Institutet

141 57 Huddinge| Novum, plan 5

08-585 854 72


Cascade depends on FSL for academic uses. For other usages please contact us for details.