Bäckman Team

My main research focus centers around the Cognition, Brain, and Aging (COBRA) project, a 3-wave longitudinal project with testing every fifth year.

Participants (n =181) were in their mid 60s at baseline.

COBRA includes measurement of dopamine (DA) D2 receptors using PET, structural and functional MRI, as well as extensive cognitive testing and assessment of life-style factors.

The key objective is to study the relation between changes in various brain parameters and changes in cognitive functions in aging, with special focus on DA.

We seek to elucidate the question of why some older persons exhibit marked decline in brain and cognition as they grow older, whereas others age gracefully. 

Team members

Lars Bäckman

Professor, Team leader

Saana Korkki

Affiliated to Research
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Martin Lövdén

Affiliated to Research

Jonna Nilsson

Affiliated to Research
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Gaia Olivo

Affiliated to Research

Selected publications

Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.
Nyberg L, Karalija N, Papenberg G, Salami A, Andersson M, Pedersen R, Vikner T, Garrett DD, Riklund K, Wåhlin A, Lövdén M, Lindenberger U, Bäckman L
Sci Rep 2022 Dec;12(1):20957

5-Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions.
Vikner T, Karalija N, Eklund A, Malm J, Lundquist A, Gallewicz N, Dahlin M, Lindenberger U, Riklund K, Bäckman L, Nyberg L, Wåhlin A
Ann Neurol 2022 Nov;92(5):871-881

Longitudinal Dopamine D2 Receptor Changes and Cerebrovascular Health in Aging.
Karalija N, Johansson J, Papenberg G, Wåhlin A, Salami A, Köhncke Y, Brandmaier AM, Andersson M, Axelsson J, Riklund K, Lövdén M, Lindenberger U, Bäckman L, Nyberg L
Neurology 2022 Sep;99(12):e1278-e1289

Sex differences in dopamine integrity and brain structure among healthy older adults: Relationships to episodic memory.
Karalija N, Papenberg G, Wåhlin A, Johansson J, Andersson M, Axelsson J, Riklund K, Lindenberger U, Nyberg L, Bäckman L
Neurobiol Aging 2021 Sep;105():272-279

Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.
Korkki SM, Papenberg G, Karalija N, Garrett DD, Riklund K, Lövdén M, Lindenberger U, Nyberg L, Bäckman L
Sci Rep 2021 Oct;11(1):21089

Distinct and Common Large-Scale Networks of the Hippocampal Long Axis in Older Age: Links to Episodic Memory and Dopamine D2 Receptor Availability.
Nordin K, Nyberg L, Andersson M, Karalija N, Riklund K, Bäckman L, Salami A
Cereb Cortex 2021 Jun;31(7):3435-3450

Mapping the landscape of human dopamine D2/3 receptors with [11C]raclopride.
Papenberg G, Jonasson L, Karalija N, Johansson J, Köhncke Y, Salami A, Andersson M, Axelsson J, Wåhlin A, Riklund K, Lindenberger U, Lövdén M, Nyberg L, Bäckman L
Brain Struct Funct 2019 Nov;224(8):2871-2882

Dopamine D2/3 Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion.
Salami A, Garrett DD, Wåhlin A, Rieckmann A, Papenberg G, Karalija N, Jonasson L, Andersson M, Axelsson J, Johansson J, Riklund K, Lövdén M, Lindenberger U, Bäckman L, Nyberg L
J Neurosci 2019 Jan;39(3):537-547

Dopamine D2 receptor availability is linked to hippocampal-caudate functional connectivity and episodic memory.
Nyberg L, Karalija N, Salami A, Andersson M, Wåhlin A, Kaboovand N, Köhncke Y, Axelsson J, Rieckmann A, Papenberg G, Garrett DD, Riklund K, Lövdén M, Lindenberger U, Bäckman L
Proc Natl Acad Sci U S A 2016 Jul;113(28):7918-23

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