Anna Rising group

Spider silk biology for biomedical applications

Biomimetic spinning of artificial spider silk (Andersson et al. Nat Chem Biol. 2018).

Research focus

We use spider silk technology for medical applications. One line of research concerns making artificial spider silk fibers for use in regenerative medicine. Another line of research concerns the use of a spider silk protein domain for efficient production of proteins and peptides, in particular for the generation of novel lung surfactant preparations. Our lab is located at Karolinska Institutet and at the Swedish University of Agricultural Sciences (SLU).

Films from Andersson, Jia et al. Nat Chem Biol. 2017:

Formation of artificial spider silk / Konstgjord spindeltråd bildas

Group members

Anna Rising


Olga Shilkova

Senior lab manager

Tina Arndt

PhD student

Sameer Hassan

Postdoctoral researcher

Nina Schiller

Postdoctoral researcher

Fredrik Bäcklund

Postdoctoral researcher

Benjamin Schmuck

Postdoctoral researcher

Magnus Hansson

Postdoctoral researcher

Juanita Francis

Research assistant

Part of the group that works at SLU:

Nathalie Gonska, PostDoc

Sumalata Sonavane, PhD student

Selected publications

Efficient protein production inspired by how spiders make silk.
Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, et al
Nat Commun 2017 05;8():15504

Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy.
Otikovs M, Andersson M, Jia Q, Nordling K, Meng Q, Andreas LB, et al
Angew. Chem. Int. Ed. Engl. 2017 10;56(41):12571-12575

Biomimetic spinning of artificial spider silk from a chimeric minispidroin.
Andersson M, Jia Q, Abella A, Lee XY, Landreh M, Purhonen P, et al
Nat. Chem. Biol. 2017 03;13(3):262-264

Toward spinning artificial spider silk.
Rising A, Johansson J
Nat. Chem. Biol. 2015 May;11(5):309-15

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells.
Wu S, Johansson J, Damdimopoulou P, Shahsavani M, Falk A, Hovatta O, et al
Biomaterials 2014 Oct;35(30):8496-502

Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.
Andersson M, Chen G, Otikovs M, Landreh M, Nordling K, Kronqvist N, et al
PLoS Biol. 2014 Aug;12(8):e1001921

Controlled assembly: a prerequisite for the use of recombinant spider silk in regenerative medicine?
Rising A
Acta Biomater 2014 Apr;10(4):1627-31

Recombinant spider silk matrices for neural stem cell cultures.
Lewicka M, Hermanson O, Rising AU
Biomaterials 2012 Nov;33(31):7712-7


Department of Neurobiology, Care Sciences and Society Neurobiologi, vårdvetenskap och samhälle (NVS)
Division of Neurogeriatrics
Blickagången 16