“One in five had completely avoided sexual relations after their diagnosis”
Doctoral thesis. Recently, Galit Andersson, defended a doctoral thesis at the Department of Public Health Sciences, Karolinska Institutet. For the thesis large surveys were conducted of transgender people and people living with HIV in Sweden to assay their quality of life.
Brain pathways of aversion identified
Study. What happens in the brain when we feel discomfort? Researchers at Karolinska Institutet are now one step closer to finding the answer. In a new study published in the journal Molecular Psychiatry they identify which pathways in the mouse brain control behaviour associated with aversion.
Social threat learning influences our decisions
Study. Learning what is dangerous by watching a video or being told (known as social learning) has just as strong an effect on our decision-making as first-hand experience of danger, researchers at Karolinska Institutet in Sweden report. The results of the study, which is published in the journal PNAS (Proceedings of the National Academy of Sciences), can help to explain why we take irrational decisions.
Newly discovered disease opens for future diabetes treatment
Study. Knowledge of a newly discovered genetic disorder, which means that a person cannot produce the protein TXNIP (thioredoxin interacting protein) in their cells, can open for the development of new diabetes drugs. This is shown in a study from Karolinska Institutet published in the journal Diabetes.
Low physical fitness in adolescence linked to higher risk of disability pension later in life
Obesity or low physical fitness during adolescence is strongly associated with disability pension later in life. This is shown in a study of more than one million Swedish men, published in Annals of Internal Medicine by researchers at Karolinska Institutet.
KI signs agreement with the International Union of Basic and Clinical Pharmacology
Collaboration. KI has now formalised its collaboration with the International Union of Basic and Clinical Pharmacology (IUPHAR) in the interests of promoting sustainable drug development and rational drug use. The agreement applies to both research and education.
DNA puzzle uncovers rare chromosome defects
Study. Using puzzle pieces from four different DNA analyses, researchers at Karolinska Institutet have been able to map three extremely complex chromosome aberrations. This has given families answers about the cause of their children’s serious symptoms. The study was published in the scientific journal PLOS Genetics and the goal is to produce a test to be used in the clinic.
New insight into cell receptors opens the way for tailored cancer drugs
Study. New findings on how cancer mutations influence Class Frizzled receptors on the cell membrane opens the way for the development of tailored drugs for rectal cancer and lung cancer. This according to researchers behind a new article published in the journal Nature Communications.
Top publications in selection
A limited selection of recent publications in high impact journals where researchers from KI are main authors.
Chronic kidney disease linked to increased risk of aortic stenosis
Kidney Dysfunction and the Risk of Developing Aortic Stenosis, Vavilis G, Bäck M, Occhino G, Trevisan M, Bellocco R, Evans M, Lindholm B, Szummer K, Carrero JJ, JACC, January 2019.
Tourette's and tics linked to high risk of cardiovascular disease
Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders, Brander G, Isomura K, Chang Z, Kuja-Halkola R, Almqvist C, Larsson H, Mataix-Cols D, Fernández de la Cruz L, JAMA Neurology, Januray 2019.
Common physical health drugs may help treat mental diseases
Repurposing HMG-CoA reductase inhibitors, L-type calcium channel antagonists and biguanides for psychiatric symptoms in serious mental illness: a within-individual cohort study in national Swedish data, Hayes JH, Lundin A, Dal H, Lewis G, Wong I, Osborn DPJ, Dalman C, JAMA Psychiatry, January 2019.
KI in the media
Latest episode of podcast on research
Do you use to blame your aggression on testosterone? Listen to the latest episode of the pod Medicinvetarna (in Swedish) to find out why that is not correct.