New biomarkers for neuroblastoma
Researchers at Sahlgrenska Academy in Gothenburg and Karolinska Institutet, among others, have identified two new significant biomarkers for the childhood cancer neuroblastoma. The findings are published in the journal Cancer Cell.
"These results may have a direct impact on disease prognosis and in the long-term also improve treatment of neuroblastoma", says Per Kogner, Professor of Child Oncology at the Department of Women’s and Children’s Health, Karolinska Institutet, and one of the study authors.
The study was led by Professor Chandrasekhar Kanduri, Sahlgrenska Academy.
Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
Tanmoy Monda, Prasanna Kumar Juvvuna, Agnete Kirkeby, Sanhita Mitra, Subazini Thankaswamy Kosalai, Larissa Traxler, Falk Hertwig, Sara Wernig-Zorc, Caroline Miranda, Lily Deland, Ruth Volland, Christoph Bartenhagen, Deniz Bartsch, Sashidhar Bandaru, Anne Engesser, Santhilal Subhash, Tommy Martinsson, Helena Carén, Levent M. Akyürek, Leo Kurian, Meena Kanduri, Maite Huarte, Per Kogner, Matthias Fischer, Chandrasekhar Kanduri
Cancer Cell, online 12 March 2018, doi: 10.1016/j.ccell.2018.01.020