Regulatory RNAs in Development, Disease and Evolution
Protein-coding sequences comprise only a small fraction (~2%) of the mammalian genome. While most of the genome was for decades thought not be operational, recent technical developments, such as Next Generation Sequencing for transcriptome analysis, have clearly demonstrated that a large part is indeed transcribed. Strikingly, most of these transcribed regions do not code for proteins, but instead produce non-coding RNAs.
For many years, RNA molecules were viewed as passive mediators in protein expression. Intense research during the last 10-15 years has however revealed unanticipated regulatory roles for non-coding RNAs. These RNAs range from 20-30 nucleotide RNAs such as Piwi-interacting (pi) RNAs, micro (mi) RNAs and small interfering (si) RNAs, to long RNAs that can be several thousands of nucleotides in length. Non-coding RNAs are now known to be involved in defense against viruses and transposable elements, regulation of endogenous gene expression, X chromosome inactivation and many other biological processes. By regulating the expression of a large number of genes, they affect most, if not all major cellular pathways and processes, with impact in the understanding of development and disease.
This Karolinska Institute conference on Regulatory RNAs in Development, Disease and Evolution will bring together some of the most influential researchers in this field, who have contributed to novel and unexpected insights regarding the function, as well as possible biological and biomedical impact, of this emergent class of molecules.
The conference is now fully booked and closed for registration. The conference will also be broadcasted by video to an adjacent room to the Wallenberg Lecture Hall, which will be open to non-registered audience. For any other questions, please contact Goncalo.Castelo-Branco@ki.se