CfA Seminar: New mechanism for biosynthesis of lipid mediators in the pathogenesis of Aspergillus-induced inflammatory diseases
Prof. Nancy Keller, University of Wisconsin,
Prof. Nancy Keller is an authority in research on the pathobiology of Aspergillus and other fungi. Recent work indicates that part of the pro-inflammatory response is due to production of lipid mediators by the invading fungi. It is increasingly recognized that inhalation of environmental fungi is a major exposure with potential to be disease-driving in asthma and other inflammatory diseases.
Prof. Keller is one of the invited key note speakers at the upcoming KiiM retreat and will at this CfA seminar provide the opportunity to listen to her research for those who are not able to attend the retreat.
Host: Sven-Erik Dahlén, Director The Centre for Allergy Research
Some recent publications:
Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang CC, Keller NP. Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci U S A. 2013 Sep 30.
Gauthier GM, Keller NP. Crossover fungal pathogens: The biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans. Fungal Genet Biol. 2013
Casavant BP, Berthier E, Theberge AB, Berthier J, Montanez-Sauri SI, Bischel LL, Brakke K, Hedman CJ, Bushman W, Keller NP, Beebe DJ. Suspended microfluidics. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10111-6.
Affeldt KJ, Brodhagen M, Keller NP. Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins (Basel). 2012 Sep;4(9):695-717.