Acupuncture does not increase fertility in women with PCOS

Published 2017-06-27 17:05. Updated 2017-06-28 08:13Denna sida på svenska
Många kvinnor vill använda akupunktur för att bli gravida. Foto: iStockMany women want to use acupuncture to become pregnant. Photo: iStock 

Acupuncture has no effect on involuntary childlessness caused by polycystic ovary syndrome (PCOS), the most effective treatment for PCOS being the drug chlomiphene, a joint international study conducted at Heilongjiang University of Chinese Medicine, China, reports. The study, which involved the participation of researchers at Karolinska Institutet, is published in JAMA.

Women with polycystic ovary syndrome (PCOS) have high levels of male sex hormone in their blood, causing irregular ovulation and difficulties conceiving. Earlier studies have shown that acupuncture reduces high levels of male sex hormone and produces more regular ovulation.

A new study conducted by an international team of researchers has examined whether acupuncture also increases the number of pregnancies and the number of babies born to women with PCOS who are trying to become pregnant. Their aim was to study if acupuncture can be used as an alternative to chlomiphene stimulation, a treatment that while effective also produces adverse reactions.

1,000 women in a clinical trial

The study was carried out at Heilongjiang University of Chinese Medicine by researchers from China, the USA, Hong Kong and Sweden in 2012–2015 and involved 27 hospitals.

1,000 women were divided into four groups, two of which received active acupuncture treatment in combination with either chlomiphene stimulation or placebo, the other two receiving a control treatment involving fewer needles inserted superficially without active stimulation, again with either chlomiphene stimulation or placebo.

Few negative side-effects

The results show that acupuncture is not an effective infertility treatment for women with PCOS who are trying to become pregnant, nor did it have any impact on chlomiphene stimulation.

“This is important information, as many women want to use acupuncture to become pregnant,” says Elisabet Stener-Victorin, docent and researcher at Karolinska Institutet’s Department of Physiology and Pharmacology and former visiting professor at Heilongjiang University of Chinese Medicine. “If you have PCOS and want to become pregnant, then drug treatment is the most effective way forward. But for women who don’t wish to become pregnant yet but who have irregular ovulation and other symptoms related to high levels of male sex hormone, acupuncture can be used to relieve the symptoms as the method has no negative side-effects.”


”Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome – A Randomized Clinical Trial”
Xiao-Ke Wu, Elisabet Stener-Victorin, Hong-Ying Kuang, Hong-Li Ma, Jing-Shu Gao, Liang-Zhen Xie, Li-Hui Hou, Zhen-Xing Hu, Xiao-Guang Shao, Jun Ge, Jin-Feng Zhang, Hui-Ying Xue, Xiao-Feng Xu, Rui-Ning Liang, Hong-Xia Ma, Hong-Wei Yang, Wei-Li Li, Dong-Mei Huang, Yun Sun, Cui-Fang Hao, Shao-Min Du, Zheng-Wang Yang, Xin Wang, Ying Yan, Xiu-Hua Chen, Ping Fu, Cai-Fei Ding, Ya-Qin Gao, Zhong-Ming Zhou, Chi Chiu Wang, Tai-Xiang Wu, Jian-Ping Liu, Ernest HY Ng, Richard S. Legro, Heping Zhang for PCOSAct Study Group
JAMA, online 27 June 2017

Clinical researchGynaecologyObstetrics