Our research is focused on the peripheral auditory system where we primarily study mechanisms underlying hearing impairment and explore novel treatment strategies.
The experimental approaches are based on in vivo models and primary cultures of the inner ear as well as human embryonic stem cell lines. Methods include functional testing of auditory function, noise exposure and molecular and structural analysis. Current research projects include:
a) Prevention of age-related hearing loss by caloric restriction or administration of antioxidants and minerals.
b) A model for enhancing the efficacy of electrical stimulation in cochlear implants using infusion of trophic factors.
c) Deriving sensory neurons from human embryonic stem cells to use for implantation into the injured inner ear.
d) Protecting inner ear cells against degenerativeprocesses by infusing cell-derived factors or implanting immature cells derived from human embryonic stem cells.
e) Developing a bioelectrode for electrical stimulation of inner ear neurons using encapsulated cells.
f) Applying novel vectors, cell-penetrating peptides, for more efficient transfection of inner ear cells.
g) Promoting cell survival and migration using structured protein patterns.
Repeated Moderate Noise Exposure in the Rat--an Early Adulthood Noise Exposure Model.
Mannström P, Kirkegaard M, Ulfendahl M
J. Assoc. Res. Otolaryngol. 2015 Dec;16(6):763-72
Dendrogenin A and B two new steroidal alkaloids increasing neural responsiveness in the deafened guinea pig.
Fransson A, de Medina P, Paillasse M, Silvente-Poirot S, Poirot M, Ulfendahl M
Front Aging Neurosci 2015 ;7():145
Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat.
Mannström P, Ulfhake B, Kirkegaard M, Ulfendahl M
Exp. Gerontol. 2013 Nov;48(11):1173-9
Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6.
Dash-Wagh S, Jacob S, Lindberg S, Fridberger A, Langel U, Ulfendahl M
Mol Ther Nucleic Acids 2012 Dec;1():e61
Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo.
Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, et al
Exp. Neurol. 2012 Jan;233(1):172-81