The research of the group is focused on the role of the hippocampus in cognitive functions involving emotional and spatial memory mechanisms.
The research of the group is focused on the role of the hippocampus in cognitive functions involving emotional and spatial memory mechanisms. The work uses a combination of behavioral and neurochemical techniques involving studies in mice and rats.
We have been particularly interested in how chemical messengers such as serotonin and neuropeptides may modulate hippocampal cognitive functions. Another major question addresses whether disturbances in emotional memory functions are underlying depressed mood in states of major depressive disorder (MDD).Our research has demonstrated the important modulatory role of central 5-HT systems for both spatial and emotional memory. The work has also identified the critical role of multiple 5-HT-receptor subtypes such as 5-HT1A, 5-HT1B and 5-HT7 receptors in hippocampally mediated cognition. The present analysis involves studies on mechanisms behind the important interactions between 5-HT1A and NMDA-glutamate receptors as well as with muscarinic systems. A particular focus involves the signaling pathways of postsynaptic 5-HT1A receptors in vivo and how they interact with NMDA-receptor subunits important for cognition and depression.
Håkan Karlsson – Docent, Research group leader (Karlsson laboratory)
Sven Ove Ögren – Professor Emeritus
Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands.
Pittalà V, Siracusa MA, Salerno L, Romeo G, Modica MN, Madjid N, et al
Eur Neuropsychopharmacol 2015 Aug;25(8):1314-23
The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory.
Stiedl O, Pappa E, Konradsson-Geuken Å, Ögren SO
Front Pharmacol 2015 ;6():162
GABA(A) receptor activation in the CA1 area of the dorsal hippocampus impairs consolidation of conditioned contextual fear in C57BL/6J mice.
Misane I, Kruis A, Pieneman AW, Ögren SO, Stiedl O
Behav. Brain Res. 2013 Feb;238():160-9
5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors.
Eriksson TM, Holst S, Stan TL, Hager T, Sjögren B, Ogren SÖ, et al
Neuropharmacology 2012 Nov;63(6):1150-60
Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, et al
Mol. Psychiatry 2013 Oct;18(10):1096-105