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Top Publications 2013

Jonas M. Fuks, Romanico B. G. Arrighi,Jessica M. Weidner, Suresh Kumar Mendu, Zhe Jin, Robert P. A. Wallin, Bence Rethi, Bryndis Birnir and Antonio Barragan
GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
PLoS Pathog. 2012 December; 8(12): e1003051.
• Article abstract

Bates M, O'Grady J, Maeurer M, Tembo J, Chilukutu L, Chabala C, Kasonde R, Mulota P, Mzyece J, Chomba M, Mukonda L, Mumba M, Kapata N, Rachow A, Clowes P, Hoelscher M, Mwaba P, Zumla A.
Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study.
Lancet Infect Dis. 2013 Jan;13(1):36-42.
• Link to the abstract in PubMed

Quince C, Lundin EE, Andreasson AN, Greco D, Rafter J, Talley NJ, Agreus L, Andersson AF, Engstrand L, D'Amato M.
The impact of Crohn's disease genes on healthy human gut microbiota: a pilot study.
Gut. 2013 Jan 7.
• Link to the abstract in PubMed

Hedlund EM, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, Sun B, Liu Y, Hosaka K, Cao Y.
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):654-9. doi: 10.1073/pnas.1209310110
• Link to the abstract in PubMed

Vanherberghen B, Olofsson PE, Forslund E, Sternberg-Simon M, Khorshidi MA, Pacouret S, Guldevall K, Enqvist M, Malmberg KJ, Mehr R, Önfelt B.
Classification of human natural killer cells based on migration behavior and cytotoxic response.
Blood. 2013 Feb 21;121(8):1326-34. doi: 10.1182/blood-2012-06-439851.
• Link to the abstract in PubMed

Göndör A.
Dynamic chromatin loops bridge health and disease in the nuclear landscape.
Semin Cancer Biol. 2013 Apr;23(2):90-8. doi: 10.1016/j.semcancer.2013.01.002
• Link to the abstract in PubMed

Yihai Cao
Erythropoietin in cancer: a dilemma in risk therapy
Trends in Edocrinology & Metabolism Volume 24, Issue 4, April 2013, Pages 190199
• Article abstract

Ute Römling, Michael Y. Galperin and Mark Gomelsky
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
Microbiology and Molecular Biology Reviews (MMBR)
• Article abstract

Gupta S, Braun M, Tischler ND, Stoltz M, Sundström KB, Björkström NK, Ljunggren HG, Klingström J.
Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis
PLoS Pathog. 2013 Mar;9(3):e1003272. doi: 10.1371/journal.ppat.1003272
• Link to the abstract in PubMed

Göndör A
Nuclear architecture and chromatin structure on the path to cancer
Semin Cancer Biol. 2013 Apr;23(2):63-4. doi: 10.1016/j.semcancer.2013.02.006.
• Link to the abstract in PubMed

Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, Podschun R, Meyer-Hoffert U, Haesler R, Midtling E, Pütsep K, McGuckin MA, Schreiber S, Saftig P, Rosenstiel P.
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Gut. 2013 Apr;62(4):520-30. doi: 10.1136/gutjnl-2011-300076
• Link to the abstract in PubMed

Heuts F, Gavier-Widén D, Carow B, Juarez J, Wigzell H, Rottenberg ME.
CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6482-7
Link to the abstract in PubMed

Cohn L, Chatterjee B, Esselborn F, Smed-Sörensen A, Nakamura N, Chalouni C, Lee BC, Vandlen R, Keler T, Lauer P, Brockstedt D, Mellman I, Delamarre L.
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.
J Exp Med. 2013 May 6;210(5):1049-63
• Link to the abstract in PubMed

Ute Römling
Microbiology: Bacterial communities as capitalist economies
Nature 497, 321322 (16 May 2013) doi:10.1038/nature12103
• Link to the article

Shaner NC, Lambert GG, Chammas A, Ni Y, Cranfill PJ, Baird MA, Sell BR, Allen JR, Day RN, Israelsson M, Davidson MW, Wang J.
A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum.
Nat Methods. 2013 May;10(5):407-9. doi: 10.1038/nmeth.2413
• Link to the abstract in PubMed

Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M.
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7
• Link to the abstract in PubMed

Zirath H, Frenzel A, Oliynyk G, Segerström L, Westermark UK, Larsson K, Munksgaard Persson M, Hultenby K, Lehtiö J, Einvik C, Påhlman S, Kogner P, Jakobsson PJ, Arsenian Henriksson M.
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10258-63
• Link to the abstract in PubMed

Cao Y
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Trends Mol Med. 2013 Aug;19(8):460-73
• Link to the abstract in PubMed

Lüthje P, Brauner H, Ramos NL, Ovregaard A, Gläser R, Hirschberg AL, Aspenström P, Brauner A.
Estrogen supports urothelial defense mechanisms
Sci Transl Med. 2013 Jun 19;5(190):190ra80
• Link to the abstract in PubMed

Venkatesh S, Workman JL, Wahlgren M, Bejarano MT.
Malaria: Molecular secrets of a parasite.
Nature. 2013 Jul 11;499(7457):156-7. doi: 10.1038/nature12407
• Link to the abstract in PubMed

Yang Y, Zhang Y, Cao Z, Ji H, Yang X, Iwamoto H, Wahlberg E, Länne T, Sun B, Cao Y.
Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues.
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12018-23
• Link to the abstract in PubMed

Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Länne T, Sun B, Li X, Liu Y, Zhang Y, Cao Y.
Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis.
Cell Metab. 2013 Jul 2;18(1):118-29. doi: 10.1016/j.cmet.2013.06.003.
• Link to the abstract in PubMed

Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P.
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Science. 2013 Jul 5;341(6141):84-7. doi: 10.1126/science.1233606.
• Link to the abstract in PubMed

Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y.
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis.
Nat Commun. 2013;4:2129. doi: 10.1038/ncomms3129.
• Link to the abstract in PubMed

Gehrmann U, Hiltbrunner S, Georgoudaki AM, Karlsson MC, Näslund TI, Gabrielsson S.
Synergistic induction of adaptive antitumor immunity by codelivery of antigen with ±-galactosylceramide on exosomes.
Cancer Res. 2013 Jul 1;73(13):3865-76. doi: 10.1158/0008-5472.CAN-12-3918.
• Link to the abstract in PubMed

Yang X, Zhang Y, Yang Y, Lim S, Cao Z, Rak J, Cao Y.
Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13932-7
• Link to the abstract in PubMed

Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Viñals F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, Uhlén M, Jirström K, Pontén F, Wohlschlegel J, Grandér D, Spruck C, Larsson LG, Sangfelt O.
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.
EMBO Mol Med. 2013 Jul;5(7):999-1018
• Link to the abstract in PubMed

Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, Chambers BJ, Rottenberg ME.
Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis
PLoS Pathog. 2013 Jul;9(7):e1003442
• Link to the abstract in PubMed

Burmakin M, Shi Y, Hedström E, Kogner P, Selivanova G.
Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro
Clin Cancer Res. 2013 Sep 15;19(18):5092-103.
• Link to the abstract in PubMed

Jakobsson HE, Abrahamsson TR, Jenmalm MC, Harris K, Quince C, Jernberg C, Björkstén B, Engstrand L, Andersson AF.
Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section
Gut. 2013 Aug 7. doi: 10.1136/gutjnl-2012-303249
• Link to the abstract in PubMed

Cao Y
Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity
Cell Metab. 2013 Oct 1;18(4):478-89
• Link to the abstract in PubMed

Hansen KD, Sabunciyan S, Langmead B, Nagy N, Curley R, Klein G, Klein E, Salamon D, Feinberg AP.
Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization.
Genome Res. 2013 Sep 25
• Link to the abstract in PubMed

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proc Natl Acad Sci U S A. 2013 Nov 25.
• Link to the abstract in PubMed

Hamsten C, Tran TA, Starkhammar M, Brauner A, Commins SP, Platts-Mills TA, van Hage M.
Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups.
J Allergy Clin Immunol. 2013 Dec;132(6):1431-1434.e6.
• Link to the abstract in PubMed

Croucher NJ, Mitchell AM, Gould KA, Inverarity D, Barquist L, Feltwell T, Fookes MC, Harris SR, Dordel J, Salter SJ, Browall S, Zemlickova H, Parkhill J, Normark S, Henriques-Normark B, Hinds J, Mitchell TJ, Bentley SD.
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.
PLoS Genet. 2013;9(10):e1003868
• Link to the abstract in PubMed

Bräutigam L, Jensen LD, Poschmann G, Nyström S, Bannenberg S, Dreij K, Lepka K, Prozorovski T, Montano SJ, Aktas O, Uhlén P, Stühler K, Cao Y, Holmgren A, Berndt C.
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20057-62.
• Link to the abstract in PubMed

Kandaswamy K, Liew TH, Wang CY, Huston-Warren E, Meyer-Hoffert U, Hultenby K, Schröder JM, Caparon MG, Normark S, Henriques-Normark B, Hultgren SJ, Kline KA.
Focal targeting by human beta-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20230-5
• Link to the abstract in PubMed

Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg CI, Westerberg LS, Snapper SB, Zhao X, Song W.
N-wasp is essential for the negative regulation of B cell receptor signaling
PLoS Biol. 2013 Nov;11(11):e1001704.
• Link to the abstract in PubMed