MTC researchers in the Gunilla Karlsson Hedestam Group publish in Immunity
MTC researchers in the Gunilla Karlsson Hedestam Group have published in Immunity this month
In their article, Paola Martinez-Murillo and colleagues (pictured above) identify a novel neutralizing antibody epitope present at the apex of the HIV-1 envelope glycoprotein (Env) spike. Single cell sorting of immunization-induced Env-specific memory B cells followed by isolation and characterization of monoclonal antibodies demonstrate how they bind the target epitope and definition of the antibody germline allele by next generation sequencing reveals the level of affinity maturation of the antibodies.
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Paola Martinez-Murillo, Karen Tran, Javier Guenaga, Gustaf Lindgren, Monika Àdori, Yu Feng, Ganesh E. Phad1, Néstor Vázquez Bernat, Shridhar Bale, Jidnyasa Ingale, Viktoriya Dubrovskaya, Sijy O’Dell, Lotta Pramanik, Mats Spångberg, Martin Corcoran, Karin Loré, John R. Mascola, Richard T. Wyatt, Gunilla B. Karlsson Hedestam
Immunity Volume 46, Issue 5, 16 May 2017, Pages 804–817.e7