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Jonas Fuxe Group

Photo: Filippa Fuxe
Photo: Filippa Fuxe

Research Projects

Mechanisms of Tissue Remodeling in Inflammation and Cancer

A fundamental principle of multi-cellular organisms is the ability of cells to interact and communicate. Tubular organs are lined by epithelial and endothelial cells that form selective barriers allowing the formation of different tissue compartments. This function is dependent on the ability of cells to polarize and establish specialized intercellular junctions that regulate flux of ions, solutes and cells across the barrier. The assembly and disassembly of these junctions is tightly regulated during development and in normal physiology, but is disturbed in pathological conditions of tissue remodeling, such as in chronic inflammation and cancer. We use a combination of in vitro studies and mouse models of chronic airway inflammation and cancer to study the role of specific growth factors and cytokines in mediating tissue remodeling and junction reorganization in endothelial and epithelial cell layers.

A major research theme in the lab is remodeling of blood and lymphatic vessels. While VEGF is a major angiogenic factor, less is known about the mechanisms that drive other types of vascular remodeling including phenotypic switches of endothelial cells leading to excessive infiltration of inflammatory cells. We are particularly interested in the role of angiopoietins and the Tie2 signaling pathway in modulating the inflammatory response by acting on blood and lymphatic vessels.

Another theme is the role of epithelial-mesenchymal transition (EMT) in tumor cell invasion and epithelial remodeling in chronic inflammation. EMT is characterized by loss of cell-cell adhesion and polarity accompanied by cytoskeletal rearrangements and increased cell motility. TGF-b is a major inducer of EMT but the molecular mechanisms involved are not clear. We are interested in transcriptional regulation of target genes downstream of the TGF-b/Smad signaling pathway.

Group Members

Jonas FuxeForskare

jonas.fuxe@ki.se

Nikolina GiotopoulouDoktorand, Forskarstuderande

nikolina.giotopoulou@ki.se

Azadeh NilchianDoktorand, Forskarstuderande

azadeh.nilchian@ki.se

Wenwen SunAnknuten, Postdoc

wenwen.sun@ki.se

Postdoc: Vacant position(s)

Alumni:

Mei-Fong Pang, PhD. PhD student in Fuxe group 2009-2012. Current position: postdoc at Princeton University, US.

Jill Johnson, PhD. Postdoc in Fuxe group 2008-2011. Current position: Research Fellow at the National Heart and Lung Institute, Imperial College London

Tove Berg, PhD. Postdoc in Fuxe group 2009-2012.

Vedrana Tabor, PhD. Postdoc in Fuxe group 2012-2014.

Sandra Travica, PhD. Postdoc in Fuxe group 2013-2014. Current position: Medical Scientific Advisor for Oncology Business at Pfizer Inc.

Publications

30385615

28916486

28590032

2016

25961925

27933184

27779199

27210762

2015

25637607

25674539

2014

25406396

25365481

22627188

Book chapter in “CANCER AND INFLAMMATION MECHANISMS: Chemical, Biological, and Clinical Aspects”. 2014 p23-39 (Wiley).

2013

23955085

23804031

23401487

2012

22627188

22975327

22954696

22624044

EMT research – not an empty promise

Fuxe J.

International Innovation, NordicFocus, September 2012;27-33

Earlier publications

Jonas Fuxe publications 2002-2011