Publications - Vascular Surgery

Denna sida på svenska

2016

Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms.
Martufi G, Lindquist Liljeqvist M, Sakalihasan N, Panuccio G, Hultgren R, Roy J, et al
J. Endovasc. Ther. 2016 Dec;23(6):957-966

Commentary on 'Plaque Echolucency and the Risk of Ischaemic Stroke in Patients with Asymptomatic Carotid Stenosis Within the First Asymptomatic Carotid Surgery Trial (ACST-1)'.
Roy J, Hedin U
Eur J Vasc Endovasc Surg 2016 05;51(5):622

Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk.
Lindquist Liljeqvist M, Hultgren R, Gasser T, Roy J
J. Vasc. Surg. 2016 Jun;63(6):1434-1442.e3

Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm.
Vorkapic E, Dugic E, Vikingsson S, Roy J, Mäyränpää M, Eriksson P, et al
Atherosclerosis 2016 Jun;249():101-9

A Majority of Admitted Patients With Ruptured Abdominal Aortic Aneurysm Undergo and Survive Corrective Treatment: A Population-Based Retrospective Cohort Study.
Hultgren R, Zommorodi S, Gambe M, Roy J
World J Surg 2016 12;40(12):3080-3087

Patients with abdominal aortic aneurysm have a high prevalence of popliteal artery aneurysms.
Tuveson V, Löfdahl H, Hultgren R
Vasc Med 2016 08;21(4):369-75

The composition of collagen in the aneurysm wall of men and women.
Villard C, Eriksson P, Hanemaaijer R, Lindeman J, Hultgren R
J. Vasc. Surg. 2017 Aug;66(2):579-585.e1

Age at detection of abdominal aortic aneurysms in siblings of patients with abdominal aortic aneurysms.
Linné A, Forsberg J, Lindström D, Ideskog E, Hultgren R
J. Vasc. Surg. 2016 Apr;63(4):883-7

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.
Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, et al
Sci Adv 2016 07;2(7):e1600224

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller C, et al
Arterioscler. Thromb. Vasc. Biol. 2016 Sep;36(9):1947-61

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al
Nature 2016 08;536(7614):86-90

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.
Miller C, Pjanic M, Wang T, Nguyen T, Cohain A, Lee J, et al
Nat Commun 2016 Jul;7():12092

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl T, Suganthan R, et al
Sci Rep 2016 Jun;6():28337

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.
Paramel Varghese G, Folkersen L, Strawbridge R, Halvorsen B, Yndestad A, Ranheim T, et al
J Am Heart Assoc 2016 May;5(5):

Heparanase expression upregulates platelet adhesion activity and thrombogenicity.
Cui H, Tan Y, Österholm C, Zhang X, Hedin U, Vlodavsky I, et al
Oncotarget 2016 Jun;7(26):39486-39496

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease.
Turner A, Martinuk A, Silva A, Lau P, Nikpay M, Eriksson P, et al
Arterioscler. Thromb. Vasc. Biol. 2016 May;36(5):972-83

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.
Ouimet M, Hennessy E, van Solingen C, Koelwyn G, Hussein M, Ramkhelawon B, et al
Arterioscler. Thromb. Vasc. Biol. 2016 May;36(5):942-951

VORTEC technique in central venous recanalization for haemodialysis access salvage.
Törnqvist P, Hedin U, Asciutto G, Engström J, Bountouris I, Kristmundsson T, et al
J Vasc Access 2016 Jan;17(1):e3-4

Disintegration of the Top Stent on Zenith Abdominal Aortic Stent-Grafts.
Lindström D, Wahlgren C, Sonesson B, Resch T
J. Endovasc. Ther. 2016 Apr;23(2):302-6

2015

Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.
Chang Y, Tseng C, Tannenberg P, Eriksson L, Yuan K, de Jesus Perez V, et al
Cardiovasc. Res. 2015 Jul;107(1):20-31

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.
Karunakaran D, Thrush A, Nguyen M, Richards L, Geoffrion M, Singaravelu R, et al
Circ. Res. 2015 Jul;117(3):266-78

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
Nurnberg S, Cheng K, Raiesdana A, Kundu R, Miller C, Kim J, et al
PLoS Genet. 2015 May;11(5):e1005155

Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury.
Eriksson L, Saxelin R, Röhl S, Roy J, Caidahl K, Nyström T, et al
J. Vasc. Res. 2015 ;52(1):41-52

VORTEC technique in central venous recanalisation for haemodialysis access salvage. Törnqvist H, Hedin U, Engström J, Bountouris I, Kristmundsson T, Sterner G, Dias NV. J Vasc Access, In press, 2015.

Gene expression signatures, pathways and networks in carotid atherosclerosis. Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, Lengquist M, Åkesson S, Wheelock C, Maegdefessel L, Gabrielsen A, Odeberg J, Hansson GK, Paulsson-Berne G, Hedin U. J Int Med, In press, 2015. 

Prediction of Rupture Sites in Abdominal Aortic Aneurysms After Finite Element Analysis.
Erhart P, Roy J, de Vries J, Liljeqvist M, Grond-Ginsbach C, Hyhlik-Dürr A, et al
J. Endovasc. Ther. 2016 Feb;23(1):115-20

Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation.
Paloschi V, Gådin J, Khan S, Björck H, Du L, Maleki S, et al
Arterioscler. Thromb. Vasc. Biol. 2015 Apr;35(4):973-80

Open Repair of Aneurysms of the Thoracoabdominal Aorta.
Kazen U, Blohmé L, Olsson C, Hultgren R
Thorac Cardiovasc Surg 2016 Jun;64(4):275-80

Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
Maegdefessel L, Spin J, Raaz U, Eken S, Toh R, Azuma J, et al
Nat Commun 2015 Feb;6():6506

Treatment of Popliteal Aneurysm in the endovascular era. Cervin, Anne, Tjärnström, Johan, Ravn, Hans, Acosta, Stefan, R. Hultgren, Welander, Martin, Björck Martin. EJVES European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. In press, 2015.

Inhibition of mast cells with CRD007 does not halt growth of small abdominal aortic aneurysm. Sillesen H1; Eldrup N2; R. Hultgren 3; Lindeman J4; Bredahl K5, Meyer C6; Thompson M7; Wanhainen A7; Wingren U8; Swedenborg J, on behalf of the AORTA Trial Investigators, The British journal of surgery. In press, 2015.

Preoperative hypofibrinogenemia is associated with increased intraoperative bleeding in ruptured abdominal aortic aneurysms.
Montán C, Johansson F, Hedin U, Wahlgren C
Thromb. Res. 2015 03;135(3):443-8

Aspirin-triggered 15-epi-lipoxin A₄ signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation.
Petri M, Laguna-Fernandez A, Tseng C, Hedin U, Perretti M, Bäck M
Int. J. Cardiol. 2015 Jan;179():370-2

Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins.
Liu A, Ming J, Fiskesund R, Ninio E, Karabina S, Bergmark C, et al
Arterioscler. Thromb. Vasc. Biol. 2015 Jan;35(1):197-205

2014

Platelet adhesion on endothelium early after vein grafting mediates leukocyte recruitment and intimal hyperplasia in a murine model.
Tseng C, Chang Y, Lengquist M, Kronqvist M, Hedin U, Eriksson E
Thromb. Haemost. 2015 Apr;113(4):813-25

Low post-operative mortality after surgery on patients with screening-detected abdominal aortic aneurysms: a Swedvasc registry study.
Linné A, Smidfelt K, Langenskiöld M, Hultgren R, Nordanstig J, Kragsterman B, et al
Eur J Vasc Endovasc Surg 2014 Dec;48(6):649-56

Perlecan heparan sulfate proteoglycan is a critical determinant of angiogenesis in response to mouse hind-limb ischemia.
Qiang B, Lim S, Lekas M, Kuliszewski M, Wolff R, Osherov A, et al
Can J Cardiol 2014 Nov;30(11):1444-51

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
Maegdefessel L, Spin J, Raaz U, Eken S, Toh R, Azuma J, et al
Nat Commun 2014 Oct;5():5214

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice.
Johansson M, Zhang X, Edfeldt K, Lundberg A, Levin M, Borén J, et al
Eur. J. Immunol. 2014 Oct;44(10):3081-92

Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury.
Gotha L, Lim S, Osherov A, Wolff R, Qiang B, Erlich I, et al
Am. J. Physiol. Heart Circ. Physiol. 2014 Aug;307(3):H337-45

Perioperative haemorrhage in endovascular abdominal aneurysm repair affects outcome.
Montán C, Wannberg M, Holst J, Wahlgren C
Eur J Vasc Endovasc Surg 2013 Jul;46(1):87-92

Perlecan Heparan Sulfate Is Required for the Inhibition of Smooth Muscle Cell Proliferation by All-trans-Retinoic Acid.
Tran-Lundmark K, Tannenberg P, Rauch B, Ekstrand J, Tran P, Hedin U, et al
J. Cell. Physiol. 2015 Feb;230(2):482-7

Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models.
Tseng C, Karlöf E, Chang Y, Lengquist M, Rotzius P, Berggren P, et al
PLoS ONE 2014 ;9(6):e98904

Synergy between shear-induced migration and secondary flows on red blood cells transport in arteries: considerations on oxygen transport.
Biasetti J, Spazzini P, Hedin U, Gasser T
J R Soc Interface 2014 Aug;11(97):20140403

Early changes of gene expression profiles in the rat model of arterial injury.
Fedorov A, Kostareva A, Raud J, Roy J, Hedin U, Razuvaev A
J Vasc Interv Radiol 2014 May;25(5):789-796.e7

Reasons for non-participation in population-based abdominal aortic aneurysm screening.
Linne A, Leander K, Lindström D, Törnberg S, Hultgren R
Br J Surg 2014 Apr;101(5):481-7

Glycolaldehyde and maleyl conjugated human serum albumin as potential macrophage-targeting carriers for molecular imaging purposes.
Gustafsson B, Hedin U, Caidahl K
Contrast Media Mol Imaging ;10(1):37-42

[CORAL does not change the treatment of atherosclerotic renal artery stenosis. However, the study reinforces the requirement for patient selection prior to balloon dilatation].
Eliasson K, Hedin U
Lakartidningen ;111(15):664-5

Urgent carotid surgery and stenting may be safe after systemic thrombolysis for stroke.
Koraen-Smith L, Troëng T, Björck M, Kragsterman B, Wahlgren C,
Stroke 2014 Mar;45(3):776-80

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, et al
PLoS Genet. 2014 Mar;10(3):e1004263

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.
Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, et al
J. Clin. Invest. 2014 Mar;124(3):1083-97

The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions.
Ovchinnikova O, Folkersen L, Persson J, Lindeman J, Ueland T, Aukrust P, et al
J. Intern. Med. 2014 Nov;276(5):525-36

Perioperative cytokine response to infection associated with elective arterial surgery.
Daryapeyma A, Aarstad H, Wahlgren C, Jonung T
Vasc Endovascular Surg 2014 Feb;48(2):116-22

A novel strategy to translate the biomechanical rupture risk of abdominal aortic aneurysms to their equivalent diameter risk: method and retrospective validation.
Gasser T, Nchimi A, Swedenborg J, Roy J, Sakalihasan N, Böckler D, et al
Eur J Vasc Endovasc Surg 2014 Mar;47(3):288-95

2013

[Tools for control of bleeding during vascular trauma].
Wahlgren C, Montán C, Hedin U
Lakartidningen ;110(7):354-7

[A centralised screening program for abdominal aortic aneurysms in Stockholm. Experiences from the first 18 months].
Hultgren R, Linné A, Löfberg H, Swedenborg J, Zuber E, Törnberg S
Lakartidningen ;110(23-24):1161-4

Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis.
Kharitonova T, Melo T, Andersen G, Egido J, Castillo J, Wahlgren N, et al
Stroke 2013 Sep;44(9):2513-8

Multidimensional growth measurements of abdominal aortic aneurysms.
Martufi G, Auer M, Roy J, Swedenborg J, Sakalihasan N, Panuccio G, et al
J. Vasc. Surg. 2013 Sep;58(3):748-55

NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis.
Liu H, Zhang X, Edfeldt K, Nijhuis M, Idborg H, Bäck M, et al
Arterioscler. Thromb. Vasc. Biol. 2013 Sep;33(9):2193-201

Venous occlusion plethysmography in patients with post-thrombotic venous claudication.
Rosfors S, Blomgren L
J. Vasc. Surg. 2013 Sep;58(3):722-6

The quasi-static failure properties of the abdominal aortic aneurysm wall estimated by a mixed experimental-numerical approach.
Forsell C, Swedenborg J, Roy J, Gasser T
Ann Biomed Eng 2013 Jul;41(7):1554-66

[The first lifesaving measures in severe injuries to the thorax and abdomen].
Riddez L, Falkén M, Sundelöf M, Wahlgren C, Ostlund A
Lakartidningen ;110(7):346-9

Identification of carotid plaque tissue properties using an experimental-numerical approach.
Heiland V, Forsell C, Roy J, Hedin U, Gasser T
J Mech Behav Biomed Mater 2013 Nov;27():226-38

Vascular training profiles across Europe.
Avgerinos E,
Eur J Vasc Endovasc Surg 2013 Dec;46(6):719-25

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.
Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, et al
Arterioscler. Thromb. Vasc. Biol. 2013 Oct;33(10):2432-43

Perioperative haemorrhage in endovascular abdominal aneurysm repair affects outcome.
Montán C, Wannberg M, Holst J, Wahlgren C
Eur J Vasc Endovasc Surg 2013 Jul;46(1):87-92

Women with abdominal aortic aneurysms have more extensive aortic neck pathology.
Hultgren R, Vishnevskaya L, Wahlgren C
Ann Vasc Surg 2013 Jul;27(5):547-52

Abdominal aortic aneurysms-gender aspects on prevalence, treatment, and concurrent aneurysms.
Hultgren R
Thorac Cardiovasc Surg 2013 Jan;61(1):15-21

2012

CT angiography of abdominal aortic aneurysms: not everything that is not white is thrombus.
Labruto F, Lundberg G, Roy J
J Vasc Interv Radiol 2012 Oct;23(10):1387-8

High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population.
Linné A, Lindström D, Hultgren R
J. Vasc. Surg. 2012 Aug;56(2):305-10

Regional variation in the incidence of abdominal aortic aneurysm in Sweden.
Hultgren R, Forsberg J, Alfredsson L, Swedenborg J, Leander K
Br J Surg 2012 May;99(5):647-53

Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia.
Chang Y, Ringman Uggla A, Osterholm C, Tran P, Eklöf A, Lengquist M, et al
Am. J. Physiol. Lung Cell Mol. Physiol. 2012 Jun;302(11):L1159-66

The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation.
Wang J, Razuvaev A, Folkersen L, Hedin E, Roy J, Brismar K, et al
Atherosclerosis 2012 Jan;220(1):102-9

2011

Thrombolysis for lower extremity bypass graft occlusion.
Koraen L, Kuoppala M, Acosta S, Wahlgren C
J. Vasc. Surg. 2011 Nov;54(5):1339-44

Reproductive history in women with abdominal aortic aneurysms.
Villard C, Swedenborg J, Eriksson P, Hultgren R
J. Vasc. Surg. 2011 Aug;54(2):341-5, 345.e1-2

Correlations between clinical variables and gene-expression profiles in carotid plaque instability.
Razuvaev A, Ekstrand J, Folkersen L, Agardh H, Markus D, Swedenborg J, et al
Eur J Vasc Endovasc Surg 2011 Dec;42(6):722-30

Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms.
Folkesson M, Silveira A, Eriksson P, Swedenborg J
Atherosclerosis 2011 Oct;218(2):294-9

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans.
Michel J, Martin-Ventura J, Egido J, Sakalihasan N, Treska V, Lindholt J, et al
Cardiovasc. Res. 2011 Apr;90(1):18-27

Imaging the intraluminal thrombus of abdominal aortic aneurysms: techniques, findings, and clinical implications.
Labruto F, Blomqvist L, Swedenborg J
J Vasc Interv Radiol 2011 Aug;22(8):1069-75; quiz 1075

Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms.
Swedenborg J, Mäyränpää M, Kovanen P
Arterioscler. Thromb. Vasc. Biol. 2011 Apr;31(4):734-40

Analysis of aortic wall stress and rupture risk in patients with abdominal aortic aneurysm with a gender perspective.
Larsson E, Labruto F, Gasser T, Swedenborg J, Hultgren R
J. Vasc. Surg. 2011 Aug;54(2):295-9

Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis.
Agardh H, Folkersen L, Ekstrand J, Marcus D, Swedenborg J, Hedin U, et al
J. Intern. Med. 2011 Feb;269(2):200-10

Prolonged exercise-induced stimulation of skeletal muscle glucose uptake is due to sustained increases in tissue perfusion and fractional glucose extraction.
Hamrin K, Qvisth V, Hagström-Toft E, Enoksson S, Henriksson J, Bolinder J
J. Clin. Endocrinol. Metab. 2011 Apr;96(4):1085-92

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.
Gertow K, Nobili E, Folkersen L, Newman J, Pedersen T, Ekstrand J, et al
Atherosclerosis 2011 Apr;215(2):411-6

High frequency of thoracic aneurysms in patients with abdominal aortic aneurysms.
Larsson E, Vishnevskaya L, Kalin B, Granath F, Swedenborg J, Hultgren R
Ann. Surg. 2011 Jan;253(1):180-4

Intravital microscopy on atherosclerosis in apolipoprotein e-deficient mice establishes microvessels as major entry pathways for leukocytes to advanced lesions.
Eriksson E
Circulation 2011 Nov;124(19):2129-38

Late follow-up of a randomized trial of routine duplex imaging before varicose vein surgery.
Blomgren L, Johansson G, Emanuelsson L, Dahlberg-Åkerman A, Thermaenius P, Bergqvist D
Br J Surg 2011 Aug;98(8):1112-6

Publication