Spatio-temporal Regulation of Signal Transduction for Insulin Secretion
Lecturer: Professor Anders Tengholm, Department of Medical Cell Biology, Uppsala University
The magnitude and temporal pattern of insulin secretion is determined by interplay between several intracellular messengers and signalling proteins in pancreatic b-cells. Live-cell imaging have shown that glucose and neuro-hormonal stimuli induce dynamic changes of the sub-plasmalemmal concentrations of e.g. ATP, Ca2+ and cyclic AMP, which contribute to pulsatile insulin secretion. Moreover, secretory products elicit auto- and paracrine signalling that influence the secretion pattern. This presentation will review some recent insights into the spatio-temporal regulation of these signalling systems and how signalling defects may contribute to impaired insulin secretion in type 2 diabetes.
Christina Bark, Department of Molecular Medicine and Surgery