Research group Klas Nordlind
The skin may be considered to be a mirror of the soul. Light from the outside world passes through the layers of epidermal cells, the first line of immune defenses, and then interacts with the neuroendocrine system. The dynamic interaction between these two extensive systems involves many molecules, among which serotonin (5-hydroxytryptamine; 5-HT) and substance P, may be of major importance.
Our research is focused at studying expression of these ligands and their receptors, also including the serotonin transporter protein, in common chronic inflammatory skin diseases, psoriasis, and the often severely itching atopic dermatitis. The patients are seen at our Neurocutaneous Reception and are characterized regarding the extent of their disease, the degree of pruritus, the degree of chronic stress, personality traits and depression. In addition, we study allergic contact dermatitis as a more well defined acute inflammatory condition.
The role of alcohol (involving these mentioned neuromediators) in psoriasis, is studied, regarding its degree of inflammation and its pruritus.
We also study these neuromediators, 5-HT and substance P, in murine models with induced allergic contact eczema (Balb/C) and atopic dermatitis (NC/Nga), respectively. In these models also the brain may be investigated.
These studies may lead to a better understanding of the complex interaction between the skin and the neuroendocrine system and lead to new treatments, both systemic and topical.
- Klas Nordlind, MD, PhD, Professor and senior consultant at the Department of Dermatology
- Sol-Britt Lonne-Rahm, MD, PhD, Senior consultant, licensed psychotherapist, at the Daycare Unit (where the Neurocutaneous reception is located)
- Husameldin El-Nour, MD, PhD, Research Assistant
- Kristofer Thorslund, MD, PhD
- Louise Lönndahl, postgraduate student
- Aram Rasul, PhD
- Kristina Dahlman-Ghozlan, MD, postgraduate student