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Allergic diseases

Om allergi

Allergic reactions can take place in many different organs, e.g., airways, skin or the gastrointestinal tract. Allergy can be either antibody- or cellmediated.

In most patients, the antibody typically responsible for an allergic reaction belongs to the IgE isotype. When IgE bound to the cell surface of mast cells encounter an allergen, e.g., pollen, the mast cell is activated and releases its content of inflammatory mediators, such as histamine, which causes the typical allergic symptoms.

Allergy research at the Karolinska Institutet combines clinical, pre-clinical and epidemiological studies to investigate the mechanisms underlying allergic reactions and to improve diagnostic procedures and treatments. Several groups are involved in the research focusing on different aspects, such as genetics, effector and regulatory cells, inflammatory mediators, characterization of allergens, development of novel therapies etc.

Research groups

Research field Research group
Clinical allergy research Annika Scheynius
Ola Winqvist

Research field Research group
Allergic immune responses, Novel therapeutic strategies Marianne van Hage
Mast cell biology Gunnar Nilsson