Neutrophils are the most abundant form of white blood corpuscles. They are the major effector cells in host defence against bacteria and fungi. Neutropenias (NP) denote a deficiency of blood neutrophils. NPs arise as a consequence of impaired production or of increased destruction of neutrophils.
Neutropenias can be severe and are then associated with increased numbers and severity of infections, often life-threatening. Many NPs are congenital and chronic; others are acquired, e.g. induced by drugs. Some are associated with autoimmune diseases. The severe NP can be treated with specific growth factors and antibiotics.
Our research is focused on the causes and management of congenital and acquired NPs
Our research is focused on the causes and management of congenital and acquired NPs and is closely associated with the care for these patients at the Hematology Center, Karolinska University Hospital Huddinge. It is the largest NP clinic in Sweden. We collaborate closely with European and US centers within a variety of networks, including the Severe Chronic Neutropenia International Registry.