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Eva Hellström-Lindberg group

Eva Hellström Lindberg research group

Our research aims at improving overall and symptom-free survival in MDS and is pursued along the following lines:

  1. Clinical trials within the Nordic MDS Group: www.nmds.org
  2. Large sequencing projects encompassing DNA and RNA sequencing aiming for personalized prognostication.
  3. Hemopoietic stem cell (HSC) studies in specific MDS subtypes aiming to understand clonal hierarchies, mechanisms for HSC-niche interactions, and response to therapy. In particular we study patients who undergo stem cell transplantation in the Nordic region.
  4. Studies of the MDS subtype refractory anemia with ring sideroblasts, MDS-RS, exploring the biological consequences of mutations in the splice factor gene SF3B1 for HSC clonal advantage and anemia, respectively.

Funding bodies

  • Knut and Alice Wallenberg Foundation
  • The Swedish Cancer Society
  • The Scientific Research Council
  • Stockholm County Council Research funds
  • Cancer Society in Stockholm
  • Nordic Cancer Union

Members

Teresa Mortera Blanco, PhD, Senior Lab manager

Monika Jansson, Med Lic, Lab manager

Marios Dimitriou, Associate professor

Martin Jädersten, MD, PhD, Senior post doc

Magnus Tobiasson, MD, PhD, Senior post doc

Gabriele Todisco, MD, Post doc

Isabel Hofman, PhD, post doc

Edda Elvarsdottir, PhD student

Maria Creignou, MD, PhD PhD student

Sara von Bahr Grebäck, PhD, Administrator

Annette Öster Fernström, PhD, Administrator

Gunilla Walldin, Research and biobank nurse

Ann-Charlotte Björklund, technician

Indira Barbosa, technician

Selected publications

30267009

30194306

29097382

Mortera-Blanco T, Dimitriou M, Woll PS, Karimi M. Elvarsdottir E, Conte S. Tobiasson M, Jansson M, Douagi I, Moari M, Saft L, Papaemmanuil E, Jacobsen, SEW. Hellström-Lindberg E. SF3B1 mutations in myelodysplastic syndromes with ring sideroblasts arise in multipotent hematopoietic stem cells. Blood. 2017 Aug 17;130(7):881-890.

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