Bengt Gårdlund group

Pathophysiology, diagnosis and treatment of severe infections

Clinical research aiming at a better understanding of the pathophysiology, diagnosis and treatment of severe infections. Clinical trials and cohort studies.

Keywords: Sepsis, ICU, severe infections, immunocompromised host, clinical trials

Members

Bengt Gårdlund, Group Leader,  MD, PhD (Docent) in infectious diseases

Presently chief physician (överläkare) working full time clinically as infectious disease consultant in the ICU and other departments (Hematology, Organ and bone marrow transplant, surgery, orthopedics etc.) at Karolinska University Hospital, Huddinge. Also taken part in workshops and working parties for designing national guidelines for the treatment of sepsis, endocarditis, fungal infections etc. Research work is focused on cooperation in various networks described below.

Physician Certificate 1980 09 29, Medical Doctor. Dissertation date: 1977 05 26. Title of thesis: Studies on the structure of human fibrinogen and on its immunological properties. Certified Specialist in Infectious Diseases 1987 01 05. Associate Professor (Docent) in Infectious Diseases 1998 02 02.

Phone: +46-8-58587014

Invasive fungal infections

Ola Blennow, MD, PhD student at the Dpt of Infectious Diseases, Karolinska University Hospital, Huddinge.

Diagnosis of severe sepsis and septic shock at the emergency department
 

Patrik Gille-Johnsson, MD, PhD student (doktorand) at Dpt of Infectious Diseases, Karolinska University Hospital, Solna. 

Analysis of an international septic shock cohort (derived from the PROWESS SHOCK clinical trial)
In cooperation with the PROWESS SHOCK academic steering committee: V. Marco Ranieri, M.D., B. Taylor Thompson, M.D., Philip S. Barie, M.D., M.B.A., Jean-François Dhainaut, M.D., Ivor S. Douglas, M.D., Simon Finfer, F.R.C.P., Bengt Gårdlund, M.D., John C. Marshall, M.D., Andrew Rhodes, M.D.
Evaluation of ELISpot technique for detecting cytokine producing leucocytes in the circulation in human sepsis
Staffan Paulie, PhD, Assoc. Prof. at Stockholm University. Mabtech AB
Christian Smedman, PhD student, Karolinska Institute and Mabtech AB
Lindvi Gudmundsdotter, PhD. Mabtech AB
Kopek Nihlmark, Quality manager, Mabtech AB
Patrik Gille-Johnsson, MD, PhD student at Dpt of Infectious Diseases, Karolinska University Hospital, Solna.
Anna Somell, MD, PhD at the Dpt of Anesthesia and Intensive Care, Karolinska University Hospital, Huddinge.

Selected publications

Duration of treatment for candidemia and risk for late-onset ocular candidiasis.
Blennow O, Tallstedt L, Hedquist B, Gårdlund B
Infection 2013 Feb;41(1):129-34

Circulating monocytes are not the major source of plasma cytokines in patients with sepsis.
Gille-Johnson P, Smedman C, Gudmundsdotter L, Somell A, Nihlmark K, Paulie S, et al
Shock 2012 Dec;38(6):577-83

Severe sepsis and systemic inflammatory response syndrome in emergency department patients with suspected severe infection.
Gille-Johnson P, Hansson K, Gårdlund B
Scand. J. Infect. Dis. 2013 Mar;45(3):186-93

Clinical and laboratory variables identifying bacterial infection and bacteraemia in the emergency department.
Gille-Johnson P, Hansson K, Gårdlund B
Scand. J. Infect. Dis. 2012 Oct;44(10):745-52

Drotrecogin alfa (activated) in adults with septic shock.
Ranieri V, Thompson B, Barie P, Dhainaut J, Douglas I, Finfer S, et al
N. Engl. J. Med. 2012 May;366(22):2055-64

FluoroSpot Analysis of TLR-Activated Monocytes Reveals Several Distinct Cytokine-Secreting Subpopulations.
Smedman C, Ernemar T, Gudmundsdotter L, Gille-Johnson P, Somell A, Nihlmark K, et al
Scand. J. Immunol. 2012 Feb;75(2):249-58

ELISpot analysis of LPS-stimulated leukocytes: human granulocytes selectively secrete IL-8, MIP-1beta and TNF-alpha.
Smedman C, Gårdlund B, Nihlmark K, Gille-Johnson P, Andersson J, Paulie S
J. Immunol. Methods 2009 Jul;346(1-2):1-8

Statistical analysis plan of PROWESS SHOCK study.
, Thompson B, Ranieri V, Finfer S, Barie P, Dhainaut J, et al
Intensive Care Med 2010 Nov;36(11):1972-3

Unblinding plan of PROWESS-SHOCK trial.
Ranieri V, Thompson B, Finfer S, Barie P, Dhainaut J, Douglas I, et al
Intensive Care Med 2011 Aug;37(8):1384-5

Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.
Finfer S, Ranieri V, Thompson B, Barie P, Dhainaut J, Douglas I, et al
Intensive Care Med 2008 Nov;34(11):1935-47

Nosocomial pneumonia in the ICU: a prospective cohort study.
Hyllienmark P, Gårdlund B, Persson J, Ekdahl K
Scand. J. Infect. Dis. 2007 ;39(8):676-82

Postoperative surgical site infections in cardiac surgery--an overview of preventive measures.
Gårdlund B
APMIS 2007 Sep;115(9):989-95

Swedish guidelines for diagnosis and treatment of infective endocarditis.
Westling K, Aufwerber E, Ekdahl C, Friman G, Gårdlund B, Julander I, et al
Scand. J. Infect. Dis. 2007 ;39(11-12):929-46

[13 cases of cervical necrotizing fasciitis--all patients survived. Surgery, antibiotics and hyperbaric oxygenation give the best results].
Stenberg A, Larsson A, Gårdlund B, Kumlien J, Lind F, Nordlander B
Lakartidningen 2004 Jul;101(28-29):2336-41

Different trends in antibiotic resistance rates at a university teaching hospital.
Sörberg M, Farra A, Ransjö U, Gårdlund B, Rylander M, Settergren B, et al
Clin. Microbiol. Infect. 2003 May;9(5):388-96

Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system.
Sörberg M, Farra A, Ransjö U, Gårdlund B, Rylander M, Wallén L, et al
Scand. J. Infect. Dis. 2002 ;34(5):372-8

Postoperative mediastinitis in cardiac surgery - microbiology and pathogenesis.
Gårdlund B, Bitkover C, Vaage J
Eur J Cardiothorac Surg 2002 May;21(5):825-30

Fewer reoperations and shorter stay in the cardiac surgical ward when stabilising the sternum with the Ley prosthesis in post-operative mediastinitis.
Astudillo R, Vaage J, Myhre U, Karevold A, Gårdlund B
Eur J Cardiothorac Surg 2001 Jul;20(1):133-9

Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study.
Reinhart K, Menges T, Gardlund B, Harm Zwaveling J, Smithes M, Vincent J, et al
Crit. Care Med. 2001 Apr;29(4):765-9

Postoperative mediastinitis in cardiac surgery - microbiology and pathogenesis.
Gårdlund B, Bitkover C, Vaage J
Eur J Cardiothorac Surg 2002 May;21(5):825-30