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Causes and consequences of criminality and psychiatric disorders

The aim of this study was to elucidate the mechanisms behind intergenerational transmissions of psychiatric problems. For this purpose, we use the large population based registries in Sweden. We have performed very large record linkages with the Multi-Generation, Migration, Twin, Education, Medical Birth, National Crime, Hospital Discharge, Cause of Death, and Conscript Registries and Censuses (1970, 1980, 1990). At least 24 theses have been based on this data.

The database with genetically informative psychiatric data from the entire Swedish population is very complex, and we have developed new statistical models to analyze causality and to understand how genes and environments influence intergenerational transmission. Using these methods we have shown that smoking during pregnancy is not causally related to offspring criminality and school achievements, that there is a common genetic etiology between schizophrenia and bipolar disorder, and that ADHD medication seems to be protective against criminality, traffic accidents, and drug abuse.

Project leader

Paul Lichtenstein

Telefon:08-524 874 24

E-post:Paul.Lichtenstein@ki.se

Partners

Project staff

Jie Song

Telefon:08-524 822 90

E-post:jie.song@ki.se

Agnieszka Butwicka

Telefon:08-524 824 28

E-post:agnieszka.butwicka@ki.se

Martin Cederlöf

E-post:martin.cederlof@ki.se

Antti Latvala

E-post:antti.latvala@ki.se

Publications

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls - CORRIGENDUM.
Pettersson E, Lichtenstein P, Larsson H, Song J, , Agrawal A, et al
Psychol Med 2019 Jan;49(2):351

Association of Fetal Growth With General and Specific Mental Health Conditions.
Pettersson E, Larsson H, D'Onofrio B, Almqvist C, Lichtenstein P
JAMA Psychiatry 2019 Feb;():

Antidepressant prescription patterns and CNS polypharmacy with antidepressants among children, adolescents, and young adults: a population-based study in Sweden.
Lagerberg T, Molero Y, D'Onofrio BM, Fernández de la Cruz L, Lichtenstein P, Mataix-Cols D, et al
Eur Child Adolesc Psychiatry 2019 Jan;():

Attention-Deficit/Hyperactivity Disorder, School Performance, and Effect of Medication.
Jangmo A, Stålhandske A, Chang Z, Chen Q, Almqvist C, Feldman I, et al
J Am Acad Child Adolesc Psychiatry 2019 Apr;58(4):423-432

Suicide Immediately After Discharge From Psychiatric Inpatient Care: A Cohort Study of Nearly 2.9 Million Discharges.
Haglund A, Lysell H, Larsson H, Lichtenstein P, Runeson B
J Clin Psychiatry 2019 Feb;80(2):

Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.
Gong T, Lundholm C, Rejnö G, Bölte S, Larsson H, D'Onofrio BM, et al
Clin. Exp. Allergy 2019 Feb;():

Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study.
Ginsberg Y, D'Onofrio BM, Rickert ME, Class QA, Rosenqvist MA, Almqvist C, et al
J Child Psychol Psychiatry 2019 Feb;60(2):160-168

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy.
Brikell I, Chen Q, Kuja-Halkola R, D'Onofrio B, Wiggs K, Lichtenstein P, et al
Epilepsia 2019 Feb;60(2):284-293

Adolescent self-harm with and without suicidality: cross-sectional and longitudinal analyses of a Swedish regional register.
Bjureberg J, Ohlis A, Ljótsson B, D'Onofrio B, Hedman-Lagerlöf E, Jokinen J, et al
J Child Psychol Psychiatry 2019 Mar;60(3):295-304

Epilepsy, antiepileptic drugs, and serious transport accidents: A nationwide cohort study.
Sundelin H, Chang Z, Larsson H, Lichtenstein P, Almqvist C, Tomson T, et al
Neurology 2018 Mar;90(13):e1111-e1118

Specificity in Etiology of Subtypes of Bipolar Disorder: Evidence From a Swedish Population-Based Family Study.
Song J, Kuja-Halkola R, Sjölander A, Bergen S, Larsson H, Landén M, et al
Biol. Psychiatry 2018 Dec;84(11):810-816

The association between body mass index and postpartum depression: A population-based study.
Silverman M, Smith L, Lichtenstein P, Reichenberg A, Sandin S
J Affect Disord 2018 11;240():193-198

Is depression more likely following childbirth? A population-based study.
Silverman M, Reichenberg A, Lichtenstein P, Sandin S
Arch Womens Ment Health 2019 Apr;22(2):253-258

Benzodiazepine prescribing for children, adolescents, and young adults from 2006 through 2013: A total population register-linkage study.
Sidorchuk A, Isomura K, Molero Y, Hellner C, Lichtenstein P, Chang Z, et al
PLoS Med. 2018 08;15(8):e1002635

Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample.
Rydell M, Lundström S, Gillberg C, Lichtenstein P, Larsson H
J Child Psychol Psychiatry 2018 Aug;59(8):863-871

Adverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study.
Rejnö G, Lundholm C, Larsson K, Larsson H, Lichtenstein P, D'Onofrio B, et al
J Allergy Clin Immunol Pract ;6(3):916-922.e6

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.
Pettersson E, Lichtenstein P, Larsson H, Song J, , Agrawal A, et al
Psychol Med 2018 Sep;():1-8

Criterion Validity and Utility of the General Factor of Psychopathology in Childhood: Predictive Associations With Independently Measured Severe Adverse Mental Health Outcomes in Adolescence.
Pettersson E, Lahey B, Larsson H, Lichtenstein P
J Am Acad Child Adolesc Psychiatry 2018 Jun;57(6):372-383

Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies.
Munk-Olsen T, Liu X, Viktorin A, Brown H, Di Florio A, D'Onofrio B, et al
Lancet Psychiatry 2018 08;5(8):644-652

Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment.
Mowlem F, Rosenqvist M, Martin J, Lichtenstein P, Asherson P, Larsson H
Eur Child Adolesc Psychiatry 2019 Apr;28(4):481-489

Parental nicotine replacement therapy and offspring bronchitis/bronchiolitis and asthma - a nationwide population-based cohort study.
Molero Y, Zetterqvist J, Lichtenstein P, Almqvist C, Ludvigsson J
Clin Epidemiol 2018 ;10():1339-1347

A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al
Mol. Psychiatry 2018 07;23(7):1652-1658

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.
Martin J, Walters R, Demontis D, Mattheisen M, Lee S, Robinson E, et al
Biol. Psychiatry 2018 Jun;83(12):1044-1053

Artistic creativity and risk for schizophrenia, bipolar disorder and unipolar depression: a Swedish population-based case-control study and sib-pair analysis.
MacCabe JH, Sariaslan A, Almqvist C, Lichtenstein P, Larsson H, Kyaga S
Br J Psychiatry 2018 06;212(6):370-376

Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes.
Kuja-Halkola R, Lind Juto K, Skoglund C, Rück C, Mataix-Cols D, Pérez-Vigil A, et al
Mol. Psychiatry 2018 Oct;():

Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up.
Isomura K, Brander G, Chang Z, Kuja-Halkola R, Rück C, Hellner C, et al
Biol. Psychiatry 2018 Sep;84(5):324-331

The familial co-aggregation of ASD and ADHD: a register-based cohort study.
Ghirardi L, Brikell I, Kuja-Halkola R, Freitag CM, Franke B, Asherson P, et al
Mol. Psychiatry 2018 02;23(2):257-262

Outcome-dependent associations between short interpregnancy interval and offspring psychological and educational problems: a population-based quasi-experimental study.
Class QA, Rickert ME, Larsson H, Öberg AS, Sujan AC, Almqvist C, et al
Int J Epidemiol 2018 08;47(4):1159-1168

The relation between the age at diagnosis of problem behaviors related to aggression and distal outcomes in Swedish children.
Campbell I, Lundstrom S, Larsson H, Lichtenstein P, Lubke G
Eur Child Adolesc Psychiatry 2018 Nov;():

No association between urbanisation, neighbourhood deprivation and IBD: a population-based study of 4 million individuals.
Butwicka A, Sariaslan A, Larsson H, Halfvarson J, Myrelid P, Olén O, et al
Gut 2019 05;68(5):947-948

Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study.
Brew B, Lundholm C, Viktorin A, Lichtenstein P, Larsson H, Almqvist C
Int J Epidemiol 2018 02;47(1):166-174

Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
Mol. Psychiatry 2018 05;23(5):1189-1197

Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population.
Yao S, Kuja-Halkola R, Thornton L, Norring C, Almqvist C, D'Onofrio B, et al
Int J Eat Disord 2017 09;50(9):1095-1103

The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
Viktorin A, Rydén E, Thase ME, Chang Z, Lundholm C, D'Onofrio BM, et al
Am J Psychiatry 2017 04;174(4):341-348

A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
Wiggs KK, Rickert ME, Hernandez-Diaz S, Bateman BT, Almqvist C, Larsson H, et al
Behav. Genet. 2017 07;47(4):383-393

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring.
Sujan AC, Rickert ME, Öberg AS, Quinn PD, Hernández-Díaz S, Almqvist C, et al
JAMA 2017 04;317(15):1553-1562

Suicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients With Bipolar Disorder.
Song J, Sjölander A, Joas E, Bergen S, Runeson B, Larsson H, et al
Am J Psychiatry 2017 08;174(8):795-802

The risk factors for postpartum depression: A population-based study.
Silverman M, Reichenberg A, Savitz D, Cnattingius S, Lichtenstein P, Hultman C, et al
Depress Anxiety 2017 02;34(2):178-187

Neighborhood Influences on Violent Reoffending Risk in Released Prisoners Diagnosed With Psychotic Disorders.
Sariaslan A, Larsson H, Lichtenstein P, Fazel S
Schizophr Bull 2017 09;43(5):1011-1020

The Heritability of Autism Spectrum Disorder.
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA 2017 09;318(12):1182-1184

Association Between Deliberate Self-harm and Violent Criminality.
Sahlin H, Kuja-Halkola R, Bjureberg J, Lichtenstein P, Molero Y, Rydell M, et al
JAMA Psychiatry 2017 06;74(6):615-621

Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.
Quinn P, Rickert M, Weibull C, Johansson A, Lichtenstein P, Almqvist C, et al
JAMA Psychiatry 2017 06;74(6):589-596

ADHD Medication and Substance-Related Problems.
Quinn P, Chang Z, Hur K, Gibbons R, Lahey B, Rickert M, et al
Am J Psychiatry 2017 09;174(9):877-885

Risk of eating disorders in immigrant populations.
Mustelin L, Hedman AM, Thornton LM, Kuja-Halkola R, Keski-Rahkonen A, Cantor-Graae E, et al
Acta Psychiatr Scand 2017 08;136(2):156-165

Association Between Medication Use and Performance on Higher Education Entrance Tests in Individuals With Attention-Deficit/Hyperactivity Disorder.
Lu Y, Sjölander A, Cederlöf M, D'Onofrio B, Almqvist C, Larsson H, et al
JAMA Psychiatry 2017 08;74(8):815-822

Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.
Longinetti E, Mariosa D, Larsson H, Ye W, Ingre C, Almqvist C, et al
Neurology 2017 Aug;89(6):578-585

Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age.
Longinetti E, Mariosa D, Larsson H, Almqvist C, Lichtenstein P, Ye W, et al
Eur. J. Neurol. 2017 01;24(1):137-142

Pharmacological treatment and risk of psychiatric hospital admission in bipolar disorder.
Joas E, Karanti A, Song J, Goodwin G, Lichtenstein P, Landén M
Br J Psychiatry 2017 03;210(3):197-202

Paternal age at childbirth and eating disorders in offspring.
Javaras K, Rickert M, Thornton L, Peat C, Baker J, Birgegård A, et al
Psychol Med 2017 Feb;47(3):576-584

Suicide in obsessive-compulsive disorder: a population-based study of 36 788 Swedish patients.
Fernández de la Cruz L, Rydell M, Runeson B, D'Onofrio B, Brander G, Rück C, et al
Mol. Psychiatry 2017 11;22(11):1626-1632

Suicide in Tourette's and Chronic Tic Disorders.
Fernández de la Cruz L, Rydell M, Runeson B, Brander G, Rück C, D'Onofrio B, et al
Biol. Psychiatry 2017 07;82(2):111-118

Identification of low risk of violent crime in severe mental illness with a clinical prediction tool (Oxford Mental Illness and Violence tool [OxMIV]): a derivation and validation study.
Fazel S, Wolf A, Larsson H, Lichtenstein P, Mallett S, Fanshawe T
Lancet Psychiatry 2017 06;4(6):461-468

The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study.
Faraone S, Ghirardi L, Kuja-Halkola R, Lichtenstein P, Larsson H
J Am Acad Child Adolesc Psychiatry 2017 Feb;56(2):167-174.e1

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
Chen Q, Kuja-Halkola R, Sjölander A, Serlachius E, Cortese S, Faraone SV, et al
J Child Psychol Psychiatry 2017 Jun;58(6):711-718

Familial aggregation of attention-deficit/hyperactivity disorder.
Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-Halkola R, Sandin S, et al
J Child Psychol Psychiatry 2017 03;58(3):231-239

Association Between Medication Use for Attention-Deficit/Hyperactivity Disorder and Risk of Motor Vehicle Crashes.
Chang Z, Quinn PD, Hur K, Gibbons RD, Sjölander A, Larsson H, et al
JAMA Psychiatry 2017 06;74(6):597-603

Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study.
Butwicka A, Långström N, Larsson H, Lundström S, Serlachius E, Almqvist C, et al
J Autism Dev Disord 2017 Jan;47(1):80-89

Parental and perinatal risk factors for sexual offending in men: a nationwide case-control study.
Babchishin KM, Seto MC, Sariaslan A, Lichtenstein P, Fazel S, Långström N
Psychol Med 2017 01;47(2):305-315

Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden.
Yao S, Kuja-Halkola R, Thornton LM, Runfola CD, D'Onofrio BM, Almqvist C, et al
JAMA Psychiatry 2016 Mar;73(3):284-91

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression.
Viktorin A, Meltzer-Brody S, Kuja-Halkola R, Sullivan PF, Landén M, Lichtenstein P, et al
Am J Psychiatry 2016 Feb;173(2):158-65

Selective serotonin re-uptake inhibitor use during pregnancy: association with offspring birth size and gestational age.
Viktorin A, Lichtenstein P, Lundholm C, Almqvist C, D'Onofrio BM, Larsson H, et al
Int J Epidemiol 2016 Feb;45(1):170-7

Autism and epilepsy: A population-based nationwide cohort study.
Sundelin HE, Larsson H, Lichtenstein P, Almqvist C, Hultman CM, Tomson T, et al
Neurology 2016 07;87(2):192-7

A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes.
Sujan AC, Rickert ME, Class QA, Coyne CA, Lichtenstein P, Almqvist C, et al
Behav. Genet. 2016 05;46(3):431-56

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, et al
Mol. Psychiatry 2016 09;21(9):1290-7

Triggers for Violent Criminality in Patients With Psychotic Disorders.
Sariaslan A, Lichtenstein P, Larsson H, Fazel S
JAMA Psychiatry 2016 08;73(8):796-803

Suicide risk after nonfatal self-harm: a national cohort study, 2000-2008.
Runeson B, Haglund A, Lichtenstein P, Tidemalm D
J Clin Psychiatry 2016 02;77(2):240-6

Understanding the covariation of tics, attention-deficit/hyperactivity, and obsessive-compulsive symptoms: A population-based adult twin study.
Pinto R, Monzani B, Leckman JF, Rück C, Serlachius E, Lichtenstein P, et al
Am. J. Med. Genet. B Neuropsychiatr. Genet. 2016 10;171(7):938-47

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
Pettersson E, Larsson H, Lichtenstein P
Mol. Psychiatry 2016 May;21(5):717-21

Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders.
Nordsletten AE, Larsson H, Crowley JJ, Almqvist C, Lichtenstein P, Mataix-Cols D
JAMA Psychiatry 2016 Apr;73(4):354-61

Killing the mother of one's child: psychiatric risk factors among male perpetrators and offspring health consequences.
Lysell H, Dahlin M, Långström N, Lichtenstein P, Runeson B
J Clin Psychiatry 2016 Mar;77(3):342-7

Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden.
Latvala A, Kuja-Halkola R, Rück C, D'Onofrio BM, Jernberg T, Almqvist C, et al
JAMA Psychiatry 2016 Dec;73(12):1268-1275

Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study.
Latvala A, Kuja-Halkola R, D'Onofrio BM, Larsson H, Lichtenstein P
Addiction 2016 10;111(10):1814-22

Premature mortality in autism spectrum disorder.
Hirvikoski T, Mittendorfer-Rutz E, Boman M, Larsson H, Lichtenstein P, Bölte S
Br J Psychiatry 2016 Mar;208(3):232-8

Age at fatherhood: heritability and associations with psychiatric disorders.
Frans EM, Lichtenstein P, Hultman CM, Kuja-Halkola R
Psychol Med 2016 10;46(14):2981-2988

Prediction of violent reoffending on release from prison: derivation and external validation of a scalable tool.
Fazel S, Chang Z, Fanshawe T, Långström N, Lichtenstein P, Larsson H, et al
Lancet Psychiatry 2016 Jun;3(6):535-43

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release.
Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
JAMA 2016 Nov;316(17):1798-1807

Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study.
Chang Z, D'Onofrio BM, Quinn PD, Lichtenstein P, Larsson H
Biol. Psychiatry 2016 12;80(12):916-922

Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings.
Cederlöf M, Larsson H, Lichtenstein P, Almqvist C, Serlachius E, Ludvigsson JF
BMC Psychiatry 2016 07;16():207

Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study.
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
JAMA Psychiatry 2016 Nov;73(11):1135-1144

The association between childhood relocations and subsequent risk of suicide attempt, psychiatric problems, and low academic achievement.
Bramson LM, Rickert ME, Class QA, Sariaslan A, Almqvist C, Larsson H, et al
Psychol Med 2016 Apr;46(5):969-79

Mental illness and suicide after self-harm among young adults: long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort.
Beckman K, Mittendorfer-Rutz E, Lichtenstein P, Larsson H, Almqvist C, Runeson B, et al
Psychol Med 2016 12;46(16):3397-3405

Improving risk assessment in schizophrenia: epidemiological investigation of criminal history factors.
Witt K, Lichtenstein P, Fazel S
Br J Psychiatry 2015 May;206(5):424-30

Age-specific suicide mortality following non-fatal self-harm: national cohort study in Sweden.
Tidemalm D, Beckman K, Dahlin M, Vaez M, Lichtenstein P, Långström N, et al
Psychol Med 2015 Jun;45(8):1699-707

Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population.
Song J, Bergen SE, Kuja-Halkola R, Larsson H, Landén M, Lichtenstein P
Bipolar Disord 2015 Mar;17(2):184-93

Attention-deficit/hyperactivity disorder and risk for substance use disorders in relatives.
Skoglund C, Chen Q, Franck J, Lichtenstein P, Larsson H
Biol. Psychiatry 2015 May;77(10):880-6

Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register.
Rück C, Larsson KJ, Lind K, Perez-Vigil A, Isomura K, Sariaslan A, et al
BMJ Open 2015 Jun;5(6):e007520

Congenital Adrenal Hyperplasia, Polycystic Ovary Syndrome and criminal behavior: A Swedish population based study.
Ohlsson Gotby A, Nordenström A, Falhammar H, Nordenskjöld A, Linden Hirschberg A, Frisén L, et al
Psychiatry Res 2015 Oct;229(3):953-9

Selective Serotonin Reuptake Inhibitors and Violent Crime: A Cohort Study.
Molero Y, Lichtenstein P, Zetterqvist J, Gumpert CH, Fazel S
PLoS Med. 2015 Sep;12(9):e1001875

Varenicline and risk of psychiatric conditions, suicidal behaviour, criminal offending, and transport accidents and offences: population based cohort study.
Molero Y, Lichtenstein P, Zetterqvist J, Gumpert CH, Fazel S
BMJ 2015 Jun;350():h2388

Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, et al
JAMA Psychiatry 2015 Aug;72(8):787-93

Paternal antisocial behavior and sons' cognitive ability: a population-based quasiexperimental study.
Latvala A, Kuja-Halkola R, Långström N, Lichtenstein P
Psychol Sci 2015 Jan;26(1):78-88

A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men.
Latvala A, Kuja-Halkola R, Almqvist C, Larsson H, Lichtenstein P
JAMA Psychiatry 2015 Oct;72(10):971-8

Sexual offending runs in families: A 37-year nationwide study.
Långström N, Babchishin KM, Fazel S, Lichtenstein P, Frisell T
Int J Epidemiol 2015 Apr;44(2):713-20

Bipolar disorder and leadership--a total population study.
Kyaga S, Lichtenstein P, Boman M, Landén M
Acta Psychiatr Scand 2015 Feb;131(2):111-9

Sex- and age-specific incidence of healthcare-register-recorded eating disorders in the complete swedish 1979-2001 birth cohort.
Javaras KN, Runfola CD, Thornton LM, Agerbo E, Birgegård A, Norring C, et al
Int J Eat Disord 2015 Dec;48(8):1070-81

Depression and violence: a Swedish population study.
Fazel S, Wolf A, Chang Z, Larsson H, Goodwin GM, Lichtenstein P
Lancet Psychiatry 2015 Mar;2(3):224-32

Depression and violence—what do we really know? – Authors' reply.
Fazel S, Goodwin GM, Lichtenstein P
Lancet Psychiatry 2015 Jun;2(6):492

Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study.
Engberg H, Butwicka A, Nordenström A, Hirschberg AL, Falhammar H, Lichtenstein P, et al
Psychoneuroendocrinology 2015 Oct;60():195-205

Substance use disorders, psychiatric disorders, and mortality after release from prison: a nationwide longitudinal cohort study.
Chang Z, Lichtenstein P, Larsson H, Fazel S
Lancet Psychiatry 2015 May;2(5):422-430

Variation in mortality risk of people released from prison - Authors' reply.
Chang Z, Lichtenstein P, Larssen H, Fazel S
Lancet Psychiatry 2015 Aug;2(8):681-682

Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden.
Chang Z, Larsson H, Lichtenstein P, Fazel S
Lancet Psychiatry 2015 Oct;2(10):891-900

Hypospadias and increased risk for neurodevelopmental disorders.
Butwicka A, Lichtenstein P, Landén M, Nordenvall AS, Nordenström A, Nordenskjöld A, et al
J Child Psychol Psychiatry 2015 Feb;56(2):155-61

Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study.
Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
Diabetes Care 2015 Mar;38(3):453-9

Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study.
Arnberg FK, Gudmundsdóttir R, Butwicka A, Fang F, Lichtenstein P, Hultman CM, et al
Lancet Psychiatry 2015 Sep;2(9):817-24

Suboptimal psychosocial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbiased national cohort in Sweden.
Strandqvist A, Falhammar H, Lichtenstein P, Hirschberg AL, Wedell A, Norrby C, et al
J. Clin. Endocrinol. Metab. 2014 Apr;99(4):1425-32

Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring.
Skoglund C, Chen Q, D'Onofrio BM, Lichtenstein P, Larsson H
J Child Psychol Psychiatry 2014 Jan;55(1):61-8

The association between schizophrenia and rheumatoid arthritis: a nationwide population-based Swedish study on intraindividual and familial risks.
Sellgren C, Frisell T, Lichtenstein P, Landèn M, Askling J
Schizophr Bull 2014 Nov;40(6):1552-9

Childhood family income, adolescent violent criminality and substance misuse: quasi-experimental total population study.
Sariaslan A, Larsson H, D'Onofrio B, Långström N, Lichtenstein P
Br J Psychiatry 2014 Oct;205(4):286-90

The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan.
Larsson H, Chang Z, D'Onofrio BM, Lichtenstein P
Psychol Med 2014 Jul;44(10):2223-9

Multiple sclerosis and psychiatric disorders: comorbidity and sibling risk in a nationwide Swedish cohort.
Johansson V, Lundholm C, Hillert J, Masterman T, Lichtenstein P, Landén M, et al
Mult. Scler. 2014 Dec;20(14):1881-91

Suicide after release from prison: a population-based cohort study from Sweden.
Haglund A, Tidemalm D, Jokinen J, Långström N, Lichtenstein P, Fazel S, et al
J Clin Psychiatry 2014 Oct;75(10):1047-53

Antipsychotics, mood stabilisers, and risk of violent crime.
Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P
Lancet 2014 Sep;384(9949):1206-14

Fetal growth and psychiatric and socioeconomic problems: population-based sibling comparison.
Class QA, Rickert ME, Larsson H, Lichtenstein P, D'Onofrio BM
Br J Psychiatry 2014 Nov;205(5):355-61

Stimulant ADHD medication and risk for substance abuse.
Chang Z, Lichtenstein P, Halldner L, D'Onofrio B, Serlachius E, Fazel S, et al
J Child Psychol Psychiatry 2014 Aug;55(8):878-85

Examining and interpreting the female protective effect against autistic behavior.
Robinson EB, Lichtenstein P, Anckarsäter H, Happé F, Ronald A
Proc. Natl. Acad. Sci. U.S.A. 2013 Mar;110(13):5258-62

Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
Power RA, Kyaga S, Uher R, MacCabe JH, Långström N, Landen M, et al
JAMA Psychiatry 2013 Jan;70(1):22-30

Population-based, multigenerational family clustering study of obsessive-compulsive disorder.
Mataix-Cols D, Boman M, Monzani B, Rück C, Serlachius E, Långström N, et al
JAMA Psychiatry 2013 Jul;70(7):709-17

Mental illness, suicide and creativity: 40-year prospective total population study.
Kyaga S, Landén M, Boman M, Hultman CM, Långström N, Lichtenstein P
J Psychiatr Res 2013 Jan;47(1):83-90

Time to hospitalization for suicide attempt by the timing of parental suicide during offspring early development.
Kuramoto SJ, Runeson B, Stuart EA, Lichtenstein P, Wilcox HC
JAMA Psychiatry 2013 Feb;70(2):149-57

ADHD and criminality: could treatment benefit prisoners with ADHD who are at higher risk of reoffending?
Ginsberg Y, Långström N, Larsson H, Lichtenstein P
Expert Rev Neurother 2013 Apr;13(4):345-8

Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.
Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ, et al
JAMA Psychiatry 2013 May;70(5):516-21

Maternal age at first birth and offspring criminality: using the children of twins design to test causal hypotheses.
Coyne CA, Långström N, Rickert ME, Lichtenstein P, D'Onofrio BM
Dev. Psychopathol. 2013 Feb;25(1):17-35

The association between teenage motherhood and poor offspring outcomes: a national cohort study across 30 years.
Coyne CA, Långström N, Lichtenstein P, D'Onofrio BM
Twin Res Hum Genet 2013 Jun;16(3):679-89

Maternal stress and infant mortality: the importance of the preconception period.
Class QA, Khashan AS, Lichtenstein P, Långström N, D'Onofrio BM
Psychol Sci 2013 Jul;24(7):1309-16

Familial aggregation of schizophrenia: the moderating effect of age at onset, parental immigration, paternal age and season of birth.
Svensson AC, Lichtenstein P, Sandin S, Öberg S, Sullivan PF, Hultman CM
Scand J Public Health 2012 Feb;40(1):43-50

Family history of schizophrenia and bipolar disorder as risk factors for autism.
Sullivan PF, Magnusson C, Reichenberg A, Boman M, Dalman C, Davidson M, et al
Arch. Gen. Psychiatry 2012 Nov;69(11):1099-1103

A novel approach to determining violence risk in schizophrenia: developing a stepped strategy in 13,806 discharged patients.
Singh JP, Grann M, Lichtenstein P, Långström N, Fazel S
PLoS ONE 2012 ;7(2):e3172722359622

Medication for attention deficit-hyperactivity disorder and criminality.
Lichtenstein P, Halldner L, Zetterqvist J, Sjölander A, Serlachius E, Fazel S, et al
N. Engl. J. Med. 2012 Nov;367(21):2006-14

Advancing paternal age and offspring violent offending: a sibling-comparison study.
Kuja-Halkola R, Pawitan Y, D'Onofrio BM, Långström N, Lichtenstein P
Dev. Psychopathol. 2012 Aug;24(3):739-53

Poor school performance in offspring of patients with schizophrenia: what are the mechanisms?
Jundong J, Kuja-Halkola R, Hultman C, Långström N, D'Onofrio BM, Lichtenstein P
Psychol Med 2012 Jan;42(1):111-23

Heritability, assortative mating and gender differences in violent crime: results from a total population sample using twin, adoption, and sibling models.
Frisell T, Pawitan Y, Långström N, Lichtenstein P
Behav. Genet. 2012 Jan;42(1):3-18

Perinatal risk factors in offenders with severe personality disorder: a population-based investigation.
Fazel S, Bakiyeva L, Cnattingius S, Grann M, Hultman CM, Lichtenstein P, et al
J. Pers. Disord. 2012 Oct;26(5):737-50

Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors.
Ellingson JM, Rickert ME, Lichtenstein P, Långström N, D'Onofrio BM
Psychol Med 2012 Jul;42(7):1547-57

Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems.
D'Onofrio BM, Rickert ME, Langström N, Donahue KL, Coyne CA, Larsson H, et al
Arch. Gen. Psychiatry 2012 Nov;69(11):1140-50

The impact of birth mode of delivery on childhood asthma and allergic diseases--a sibling study.
Almqvist C, Cnattingius S, Lichtenstein P, Lundholm C
Clin. Exp. Allergy 2012 Sep;42(9):1369-76

Violent offending and IQ level as predictors of suicide in schizophrenia: national cohort study.
Webb RT, Långström N, Runeson B, Lichtenstein P, Fazel S
Schizophr. Res. 2011 Aug;130(1-3):143-7

Familial clustering of suicide risk: a total population study of 11.4 million individuals.
Tidemalm D, Runeson B, Waern M, Frisell T, Carlström E, Lichtenstein P, et al
Psychol Med 2011 Dec;41(12):2527-34

A genetically informed study of associations between family functioning and child psychosocial adjustment.
Schermerhorn AC, D'Onofrio BM, Turkheimer E, Ganiban JM, Spotts EL, Lichtenstein P, et al
Dev Psychol 2011 May;47(3):707-25

Increased suicide risk in coeliac disease--a Swedish nationwide cohort study.
Ludvigsson JF, Sellgren C, Runeson B, Långström N, Lichtenstein P
Dig Liver Dis 2011 Aug;43(8):616-22

Does maternal weight gain in pregnancy have long-term effects on offspring adiposity? A sibling study in a prospective cohort of 146,894 men from 136,050 families.
Lawlor DA, Lichtenstein P, Fraser A, Långström N
Am. J. Clin. Nutr. 2011 Jul;94(1):142-8

Creativity and mental disorder: family study of 300,000 people with severe mental disorder.
Kyaga S, Lichtenstein P, Boman M, Hultman C, Långström N, Landén M
Br J Psychiatry 2011 Nov;199(5):373-9

Alcohol use disorders in schizophrenia: a national cohort study of 12,653 patients.
Jones RM, Lichtenstein P, Grann M, Långström N, Fazel S
J Clin Psychiatry 2011 Jun;72(6):775-9; quiz 878-9

Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies.
Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A
Mol. Psychiatry 2011 Dec;16(12):1203-12

Violent crime runs in families: a total population study of 12.5 million individuals.
Frisell T, Lichtenstein P, Långström N
Psychol Med 2011 Jan;41(1):97-105

Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective.
Frans EM, McGrath JJ, Sandin S, Lichtenstein P, Reichenberg A, Långström N, et al
Schizophr. Res. 2011 Dec;133(1-3):120-4

Risk of violent crime in individuals with epilepsy and traumatic brain injury: a 35-year Swedish population study.
Fazel S, Lichtenstein P, Grann M, Långström N
PLoS Med. 2011 Dec;8(12):e1001150

Maternal bereavement and childhood asthma-analyses in two large samples of Swedish children.
Fang F, Höglund CO, Arck P, Lundholm C, Långström N, Lichtenstein P, et al
PLoS ONE 2011 ;6(11):e27202

D'Onofrio BM, Langstrom N, Lichtenstein P. The Need for Family Research Using Multiple Approaches and Methods. Natl Symp Fam Iss 2011:149-59.

Long-term follow-up of transsexual persons undergoing sex reassignment surgery: cohort study in Sweden.
Dhejne C, Lichtenstein P, Boman M, Johansson AL, Långström N, Landén M
PLoS ONE 2011 Feb;6(2):e16885

Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies.
Class QA, Lichtenstein P, Långström N, D'Onofrio BM
Psychosom Med 2011 Apr;73(3):234-41

Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death.
Wilcox HC, Kuramoto SJ, Lichtenstein P, Långström N, Brent DA, Runeson B
J Am Acad Child Adolesc Psychiatry 2010 May;49(5):514-23; quiz 530

Method of attempted suicide as predictor of subsequent successful suicide: national long term cohort study.
Runeson B, Tidemalm D, Dahlin M, Lichtenstein P, Långström N
BMJ 2010 Jul;341():c3222

Maternal or paternal suicide and offspring's psychiatric and suicide-attempt hospitalization risk.
Kuramoto SJ, Stuart EA, Runeson B, Lichtenstein P, Långström N, Wilcox HC
Pediatrics 2010 Nov;126(5):e1026-32

Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link.
Kuja-Halkola R, D'Onofrio BM, Iliadou AN, Långström N, Lichtenstein P
Int J Epidemiol 2010 Dec;39(6):1531-40

Bipolar disorder and violent crime: new evidence from population-based longitudinal studies and systematic review.
Fazel S, Lichtenstein P, Grann M, Goodwin GM, Långström N
Arch. Gen. Psychiatry 2010 Sep;67(9):931-8

Bipolar disorder and violent crime: time at risk reanalysis.
Fazel S, Lichtenstein P, Frisell T, Grann M, Goodwin G, Långström N
Arch. Gen. Psychiatry 2010 Dec;67(12):1325-6

A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement.
D'Onofrio BM, Singh AL, Iliadou A, Lambe M, Hultman CM, Neiderhiser JM, et al
Child Dev ;81(1):80-100

Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden.
D'Onofrio BM, Singh AL, Iliadou A, Lambe M, Hultman CM, Grann M, et al
Arch. Gen. Psychiatry 2010 May;67(5):529-38

Svensson et al. respond to "Maternal genes and environment in preterm birth".
Svensson AC, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman CM, et al
Am. J. Epidemiol. 2009 Dec;170(11):1386-7

Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families.
Svensson AC, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman CM, et al
Am. J. Epidemiol. 2009 Dec;170(11):1365-72

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.
Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, et al
Lancet 2009 Jan;373(9659):234-9

Schizophrenia, substance abuse, and violent crime.
Fazel S, Långström N, Hjern A, Grann M, Lichtenstein P
JAMA 2009 May;301(19):2016-23

Risk factors for violent crime in Schizophrenia: a national cohort study of 13,806 patients.
Fazel S, Grann M, Carlström E, Lichtenstein P, Långström N
J Clin Psychiatry 2009 Mar;70(3):362-9

Familial aggregation of amyotrophic lateral sclerosis.
Fang F, Kamel F, Lichtenstein P, Bellocco R, Sparén P, Sandler DP, et al
Ann. Neurol. 2009 Jul;66(1):94-9

Covariance component models for multivariate binary traits in family data analysis.
Yip BH, Björk C, Lichtenstein P, Hultman CM, Pawitan Y
Stat Med 2008 Mar;27(7):1086-105

Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long term follow-up.
Tidemalm D, Långström N, Lichtenstein P, Runeson B
BMJ 2008 Nov;337():a2205

Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death.
Nilsson E, Hultman CM, Cnattingius S, Olausson PO, Björk C, Lichtenstein P
Br J Psychiatry 2008 Oct;193(4):311-5

Advancing paternal age and bipolar disorder.
Frans EM, Sandin S, Reichenberg A, Lichtenstein P, Långström N, Hultman CM
Arch. Gen. Psychiatry 2008 Sep;65(9):1034-40

Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective.
Svensson AC, Lichtenstein P, Sandin S, Hultman CM
Schizophr. Res. 2007 Mar;91(1-3):238-45

Adverse pregnancy outcomes in mothers with affective psychosis.
MacCabe JH, Martinsson L, Lichtenstein P, Nilsson E, Cnattingius S, Murray RM, et al
Bipolar Disord 2007 May;9(3):305-9

Familial aggregation of small-for-gestational-age births: the importance of fetal genetic effects.
Svensson AC, Pawitan Y, Cnattingius S, Reilly M, Lichtenstein P
Am. J. Obstet. Gynecol. 2006 Feb;194(2):475-9

Recurrence risks for schizophrenia in a Swedish national cohort.
Lichtenstein P, Björk C, Hultman CM, Scolnick E, Sklar P, Sullivan PF
Psychol Med 2006 Oct;36(10):1417-25

Pawitan Y, Reilly M, Nilsson E, Cnattingius S, Lichtenstein P. Estimation of genetic and environmental factors for binary traits using family data - by Y. Pawitan, M. Reilly, E. Nilsson, S. Cnattingius and P. Lichtenstein, statistics in medicine 2004; 23 : 449-465 - Authors' reply. Statistics in medicine 2005;24:1617-8.

Fetal growth restriction and schizophrenia: a Swedish twin study.
Nilsson E, Stålberg G, Lichtenstein P, Cnattingius S, Olausson PO, Hultman CM
Twin Res Hum Genet 2005 Aug;8(4):402-8

Estimation of genetic and environmental factors for binary traits using family data.
Pawitan Y, Reilly M, Nilsson E, Cnattingius S, Lichtenstein P
Stat Med 2004 Feb;23(3):449-65

The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study.
Nilsson E, Salonen Ros H, Cnattingius S, Lichtenstein P
BJOG 2004 Mar;111(3):200-6

Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study.
Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P
Am. J. Med. Genet. A 2004 Nov;130A(4):365-71

Genetic influence on dystocia.
Algovik M, Nilsson E, Cnattingius S, Lichtenstein P, Nordenskjöld A, Westgren M
Acta Obstet Gynecol Scand 2004 Sep;83(9):832-7

Women with schizophrenia: pregnancy outcome and infant death among their offspring.
Nilsson E, Lichtenstein P, Cnattingius S, Murray RM, Hultman CM
Schizophr. Res. 2002 Dec;58(2-3):221-9