Publications related to Protein Science Facility

The following publications have been done with support from Protein Science Facility

2018 publications

  1. A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.
    Rozman Grinberg I, Lundin D, Sahlin M, Crona M, Berggren G, Hofer A, et al
    J. Biol. Chem. 2018 10;293(41):15889-15900
  2. Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
    Ge C, Xu B, Liang B, Lönnblom E, Lundström S, Zubarev R, et al
    2019 Feb;71(2):210-221
  3. BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence.
    Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B
    PLoS ONE 2018 ;13(8):e0202057
  4. STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
    Desroses M, Busker S, Astorga-Wells J, Attarha S, Kolosenko I, Zubarev R, et al
    J Pharm Biomed Anal 2018 Oct;160():80-88
  5. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
    Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
    Nat. Med. 2018 Jul;24(7):927-930
  6. Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
    Holechek J, Lease R, Thorsell A, Karlberg T, McCadden C, Grant R, et al
    Bioorg. Med. Chem. Lett. 2018 06;28(11):2050-2054
  7. The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
    Steiner E, Lyngsø J, Guy J, Bourenkov G, Lindqvist Y, Schneider T, et al
    Proteins 2018 09;86(9):912-923
  8. Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae.
    Han X, Sun R, Sandalova T, Achour A
    Open Biol 2018 04;8(4):
  9. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
    Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P
    Toxins (Basel) 2018 04;10(4):
  10. Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
    Morgunova E, Yin Y, Das P, Jolma A, Zhu F, Popov A, et al
    Elife 2018 04;7():
  11. The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
    Hafstrand I, Doorduijn E, Sun R, Talyzina A, Sluijter M, Pellegrino S, et al
    J. Immunol. 2018 04;200(8):2860-2868
  12. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
    Stafford W, Peng X, Olofsson M, Zhang X, Luci D, Lu L, et al
    Sci Transl Med 2018 Feb;10(428):
  13. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
    Carter M, Jemth A, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin K, et al
    Structure 2018 02;26(2):295-303.e6
  14. Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
    Rozman Grinberg I, Lundin D, Hasan M, Crona M, Jonna V, Loderer C, et al
    Elife 2018 02;7():
  15. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
    Page B, Valerie N, Wright R, Wallner O, Isaksson R, Carter M, et al
    Nat Commun 2018 01;9(1):250
  16. Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol.
    Ekblad T, Verheugd P, Lindgren A, Nyman T, Elofsson M, Schüler H
    SLAS Discov 2018 Apr;23(4):353-362
  17. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
    Narwal M, Jemth A, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, et al
    Biochemistry 2018 02;57(5):593-603

2017 publications

  1. A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
    Carreras-Puigvert J, Zitnik M, Jemth A, Carter M, Unterlass J, Hallström B, et al
    Nat Commun 2017 11;8(1):1541
  2. Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
    Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, et al
    J. Clin. Endocrinol. Metab. 2018 02;103(2):710-721
  3. Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
    Kumar R, Moche M, Winblad B, Pavlov P
    Sci Rep 2017 Oct;7(1):14288
  4. Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.
    Gustafsson R, Berntsson R, Martínez-Carranza M, El Tekle G, Odegrip R, Johnson E, et al
    FEBS Lett. 2017 11;591(22):3781-3792
  5. Entirely enzymatic nanofabrication of DNA-protein conjugates.
    Bernardinelli G, Högberg B
    Nucleic Acids Res. 2017 Oct;45(18):e160
  6. Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.
    Brunner K, Steiner E, Reshma R, Sriram D, Schnell R, Schneider G
    Bioorg. Med. Chem. Lett. 2017 10;27(19):4582-4587
  7. Capturing LTA hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB synthesis.
    Stsiapanava A, Samuelsson B, Haeggström J
    Proc. Natl. Acad. Sci. U.S.A. 2017 09;114(36):9689-9694
  8. Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3.
    Andresen C, Niklasson M, Cassman Eklöf S, Wallner B, Lundström P
    PLoS ONE 2017 ;12(7):e0181721
  9. Structural basis for dolichylphosphate mannose biosynthesis.
    Gandini R, Reichenbach T, Tan T, Divne C
    Nat Commun 2017 07;8(1):120
  10. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
    Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, et al
    JCI Insight 2017 Jul;2(13):
  11. Mucin-Inspired Lubrication on Hydrophobic Surfaces.
    Käsdorf B, Weber F, Petrou G, Srivastava V, Crouzier T, Lieleg O
    Biomacromolecules 2017 Aug;18(8):2454-2462
  12. Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.
    Mittal M, Hasan M, Balagunaseelan N, Fauland A, Wheelock C, Rådmark O, et al
    Biochim Biophys Acta Gen Subj 2017 Aug;1861(8):2099-2111
  13. Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
    Upton K, Meyers M, Thorsell A, Karlberg T, Holechek J, Lease R, et al
    Bioorg. Med. Chem. Lett. 2017 07;27(13):2907-2911
  14. Impact of cytosine methylation on DNA binding specificities of human transcription factors.
    Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, et al
    Science 2017 05;356(6337):
  15. SnoN Stabilizes the SMAD3/SMAD4 Protein Complex.
    Walldén K, Nyman T, Hällberg B
    Sci Rep 2017 Apr;7():46370
  16. Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy.
    B Kumar R, Zhu L, Hebert H, Jegerschöld C
    J Vis Exp 2017 03;(121):
  17. Binding and processing of β-lactam antibiotics by the transpeptidase Ldt from Mycobacterium tuberculosis.
    Steiner E, Schneider G, Schnell R
    FEBS J. 2017 03;284(5):725-741
  18. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
    Herold N, Rudd S, Ljungblad L, Sanjiv K, Myrberg I, Paulin C, et al
    Nat. Med. 2017 Feb;23(2):256-263
  19. Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in the Yersinia Type III Secretion System.
    Ho O, Rogne P, Edgren T, Wolf-Watz H, Login F, Wolf-Watz M
    J. Biol. Chem. 2017 02;292(8):3299-3311
  20. Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
    Peng B, Thorsell A, Karlberg T, Schüler H, Yao S
    Angew. Chem. Int. Ed. Engl. 2017 01;56(1):248-253

2016 publications

  1. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
    Thorsell A, Ekblad T, Karlberg T, Löw M, Pinto A, Trésaugues L, et al
    J. Med. Chem. 2017 02;60(4):1262-1271
  2. Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
    Quistgaard E, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, et al
    BMC Biol. 2016 Sep;14(1):82
  3. Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
    Säll A, Walle M, Wingren C, Müller S, Nyman T, Vala A, et al
    Protein Eng. Des. Sel. 2016 10;29(10):427-437
  4. The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
    Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, et al
    Sci Rep 2016 09;6():32371
  5. NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
    Valerie N, Hagenkort A, Page B, Masuyer G, Rehling D, Carter M, et al
    Cancer Res. 2016 09;76(18):5501-11
  6. A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
    Crona M, Codó P, Jonna V, Hofer A, Fernandes A, Tholander F
    Mol Oncol 2016 11;10(9):1375-1386
  7. A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
    Lundbäck P, Lea J, Sowinska A, Ottosson L, Fürst C, Steen J, et al
    Hepatology 2016 11;64(5):1699-1710
  8. Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
    Anandapadamanaban M, Pilstål R, Andresen C, Trewhella J, Moche M, Wallner B, et al
    Structure 2016 08;24(8):1311-1321
  9. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
    Schulte T, Liu L, Panas M, Thaa B, Dickson N, Götte B, et al
    Open Biol 2016 Jul;6(7):
  10. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
    Brunner K, Maric S, Reshma R, Almqvist H, Seashore-Ludlow B, Gustavsson A, et al
    J. Med. Chem. 2016 07;59(14):6848-59
  11. Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
    Mittal M, Kumar R, Balagunaseelan N, Hamberg M, Jegerschöld C, Rådmark O, et al
    Bioorg. Med. Chem. Lett. 2016 08;26(15):3547-51
  12. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
    Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, et al
    Mol. Microbiol. 2016 09;101(6):954-67
  13. Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
    Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M
    Proc. Natl. Acad. Sci. U.S.A. 2016 May;113(19):5251-6
  14. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
    Kouznetsova E, Kanno T, Karlberg T, Thorsell A, Wisniewska M, Kursula P, et al
    Structure 2016 05;24(5):789-796
  15. Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
    Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger G, Samland A
    Acta Crystallogr D Struct Biol 2016 Apr;72(Pt 4):467-76
  16. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
    Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, et al
    Nat Commun 2016 Mar;7():11040
  17. A saposin-lipoprotein nanoparticle system for membrane proteins.
    Frauenfeld J, Löving R, Armache J, Sonnen A, Guettou F, Moberg P, et al
    Nat. Methods 2016 Apr;13(4):345-51
  18. Coxsackievirus counters the host innate immune response by blocking type III interferon expression.
    Lind K, Svedin E, Domsgen E, Kapell S, Laitinen O, Moll M, et al
    J. Gen. Virol. 2016 06;97(6):1368-1380
  19. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
    Mills S, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter B
    Biochemistry 2016 Mar;55(9):1384-97
  20. Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
    Pinto A, Ebrahimi M, Saleeb M, Forsberg , Elofsson M, Schüler H
    J Biomol Screen 2016 Jul;21(6):590-5
  21. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.
    Jacewicz A, Schnell R, Lindqvist Y, Schneider G
    Acta Crystallogr F Struct Biol Commun 2016 Feb;72(Pt 2):105-11
  22. The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
    Hafstrand I, Doorduijn E, Duru A, Buratto J, Oliveira C, Sandalova T, et al
    J. Immunol. 2016 Mar;196(5):2327-34
  23. The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
    Lim S, Yeung K, Trésaugues L, Ling T, Nordlund P
    FEBS J. 2016 Mar;283(6):1107-23
  24. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
    Llona-Minguez S, Höglund A, Jacques S, Johansson L, Calderón-Montaño J, Claesson M, et al
    J. Med. Chem. 2016 Feb;59(3):1140-1148
  25. A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
    Brock J, Hamberg M, Balagunaseelan N, Goodman M, Morgenstern R, Strandback E, et al
    Proc. Natl. Acad. Sci. U.S.A. 2016 Jan;113(4):972-7

2015 publications

  1. Structural insights into the DNA-binding specificity of E2F family transcription factors.
    Morgunova E, Yin Y, Jolma A, Dave K, Schmierer B, Popov A, et al
    Nat Commun 2015 Dec;6():10050
  2. Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.
    Hassan N, Geiger B, Gandini R, Patel B, Kittl R, Haltrich D, et al
    Appl. Microbiol. Biotechnol. 2016 Apr;100(8):3533-43
  3. DNA-dependent formation of transcription factor pairs alters their binding specificity.
    Jolma A, Yin Y, Nitta K, Dave K, Popov A, Taipale M, et al
    Nature 2015 Nov;527(7578):384-8
  4. Exploring water as building bricks in enzyme engineering.
    Hendil-Forssell P, Martinelle M, Syrén P
    Chem. Commun. (Camb.) 2015 Dec;51(97):17221-4
  5. Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
    Possner D, Claesson M, Guy J
    PLoS ONE 2015 ;10(8):e0136239
  6. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
    Carter M, Jemth A, Hagenkort A, Page B, Gustafsson R, Griese J, et al
    Nat Commun 2015 Aug;6():7871
  7. Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
    Liu Q, Chai J, Moche M, Guy J, Lindqvist Y, Shanklin J
    Plant Physiol. 2015 Sep;169(1):432-41
  8. Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
    Tan T, Kracher D, Gandini R, Sygmund C, Kittl R, Haltrich D, et al
    Nat Commun 2015 Jul;6():7542
  9. Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
    Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, et al
    PLoS ONE 2015 ;10(6):e0131507
  10. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
    Ahmad S, Thulasingam M, Palombo I, Daley D, Johnson K, Morgenstern R, et al
    Biochim. Biophys. Acta 2015 Oct;1854(10 Pt A):1365-71
  11. Structure of the nuclease subunit of human mitochondrial RNase P.
    Reinhard L, Sridhara S, Hällberg B
    Nucleic Acids Res. 2015 Jun;43(11):5664-72
  12. Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.
    Poyraz , Brunner K, Lohkamp B, Axelsson H, Hammarström L, Schnell R, et al
    PLoS ONE 2015 ;10(3):e0121494
  13. High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.
    Hassan N, Kori L, Gandini R, Patel B, Divne C, Tan T
    Acta Crystallogr F Struct Biol Commun 2015 Mar;71(Pt 3):338-45
  14. Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
    Schmidberger J, Schnell R, Schneider G
    Acta Crystallogr. D Biol. Crystallogr. 2015 Mar;71(Pt 3):721-31
  15. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
    Karlberg T, Klepsch M, Thorsell A, Andersson C, Linusson A, Schüler H
    J. Biol. Chem. 2015 Mar;290(12):7336-44
  16. Acid–Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
    Stellmacher L, Sandalova T, Leptihn S, Schneider G, Sprenger GA, Samland AK
    ChemCatChem 2015, Oct 5; 7(19):3140-3151

2014 publications

  1.     An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein.
    Seijsing J, Lindborg M, Höidén-Guthenberg I, Bönisch H, Guneriusson E, Frejd F, et al
    Proc. Natl. Acad. Sci. U.S.A. 2014 Dec;111(48):17110-5
  2.     Effects of terminal dimethylation and metal coordination of proline-2-formylpyridine thiosemicarbazone hybrids on lipophilicity, antiproliferative activity, and hR2 RNR inhibition.
    Bacher F, Dömötör O, Kaltenbrunner M, Mojović M, Popović-Bijelić A, Gräslund A, et al
    Inorg Chem 2014 Dec;53(23):12595-609
  3.     A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis.
    Ullmann E, Tan T, Gundinger T, Herwig C, Divne C, Spadiut O
    Biosci. Rep. 2014 Dec;34(6):e00167
  4.     Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.
    Hassan N, Nguyen T, Intanon M, Kori L, Patel B, Haltrich D, et al
    Appl. Microbiol. Biotechnol. 2015 Feb;99(4):1731-44
  5.     Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
    Guettou F, Quistgaard E, Raba M, Moberg P, Löw C, Nordlund P
    Nat. Struct. Mol. Biol. 2014 Aug;21(8):728-31
  6.     Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.
    Pinto A, Schüler H
    Curr. Top. Microbiol. Immunol. 2015 ;384():153-66
  7.     Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.
    Dovega R, Tsutakawa S, Quistgaard E, Anandapadamanaban M, Löw C, Nordlund P
    PLoS ONE 2014 ;9(7):e101846
  8.     Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
    Löw C, Quistgaard E, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P
    Biol. Chem. 2014 Jul;395(7-8):881-9
  9.     Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
    Swarbrick C, Roman N, Cowieson N, Patterson E, Nanson J, Siponen M, et al
    J. Biol. Chem. 2014 Aug;289(35):24263-74
  10.     Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
    Dobritzsch D, Wang H, Schneider G, Yu S
    Biochem. J. 2014 Sep;462(3):441-52
  11.     Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder.
    Ponnusamy R, Lebedev A, Pahlow S, Lohkamp B
    Acta Crystallogr. D Biol. Crystallogr. 2014 Jun;70(Pt 6):1680-94
  12.     Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.
    Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, et al
    J. Biol. Chem. 2014 Jun;289(26):18175-88
  13.     Structure and inhibition of mouse leukotriene C4 synthase.
    Niegowski D, Kleinschmidt T, Ahmad S, Qureshi A, Mårback M, Rinaldo-Matthis A, et al
    PLoS ONE 2014 ;9(5):e96763
  14.     Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
    Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, et al
    Structure 2014 May;22(5):744-55
  15.     MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
    Gad H, Koolmeister T, Jemth A, Eshtad S, Jacques S, Ström C, et al
    Nature 2014 Apr;508(7495):215-21
  16.     ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
    Marteyn B, Karimova G, Fenton A, Gazi A, West N, Touqui L, et al
    MBio 2014 Mar;5(2):e00022-14
  17.     Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
    Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev R, et al
    Proc. Natl. Acad. Sci. U.S.A. 2014 Mar;111(11):4227-32
  18.     Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
    Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, et al
    J. Exp. Med. 2014 Mar;211(3):405-11
  19.     Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
    Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, et al
    J. Med. Chem. 2014 Mar;57(6):2807-12
  20.     Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
    Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, et al
    MBio 2014 Feb;5(1):e01120-13
  21.     Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.
    Tan T, Spadiut O, Gandini R, Haltrich D, Divne C
    PLoS ONE 2014 ;9(1):e86736
  22.     The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
    Schulte T, Löfling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, et al
    Open Biol 2014 Jan;4():130090
  23.     Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
    Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggström J
    J. Biol. Chem. 2014 Feb;289(8):5199-207
  24.     Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
    Stsiapanava A, Tholander F, Kumar R, Qureshi A, Niegowski D, Hasan M, et al
    Biochim. Biophys. Acta 2014 Feb;1844(2):439-46
  25.     RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
    Böth D, Steiner E, Izumi A, Schneider G, Schnell R
    Biochem. J. 2014 Jan;457(1):33-41


2013 publications

  1.     Nanobody mediated crystallization of an archeal mechanosensitive channel.
    Löw C, Yau Y, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard E, et al
    PLoS ONE 2013 ;8(10):e77984
  2.     Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
    Lindgren A, Karlberg T, Ekblad T, Spjut S, Thorsell A, Andersson C, et al
    J. Med. Chem. 2013 Dec;56(23):9556-68
  3.     Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.
    Quistgaard E, Löw C, Moberg P, Nordlund P
    J. Struct. Biol. 2013 Nov;184(2):375-8
  4.     Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.
    Cukier C, Hope A, Elamin A, Moynie L, Schnell R, Schach S, et al
    ACS Chem. Biol. 2013 Nov;8(11):2518-27
  5.     Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.
    Quistgaard E, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P
    PLoS ONE 2013 ;8(8):e71111
  6.     Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis.
    Poyraz O, Jeankumar V, Saxena S, Schnell R, Haraldsson M, Yogeeswari P, et al
    J. Med. Chem. 2013 Aug;56(16):6457-66
  7.     Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
    Guettou F, Quistgaard E, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, et al
    EMBO Rep. 2013 Sep;14(9):804-10
  8.     High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.
    Anandapadamanaban M, Andresen C, Helander S, Ohyama Y, Siponen M, Lundström P, et al
    Nat. Struct. Mol. Biol. 2013 Aug;20(8):1008-14
  9.     Substrate specificity and oligomerization of human GMP synthetase.
    Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, et al
    J. Mol. Biol. 2013 Nov;425(22):4323-33
  10.     Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
    Chen M, Lohkamp B, Schnell R, Lescar J, Schneider G
    PLoS ONE 2013 ;8(6):e66936
  11.     PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
    Lindgren A, Karlberg T, Thorsell A, Hesse M, Spjut S, Ekblad T, et al
    ACS Chem. Biol. 2013 Aug;8(8):1698-703
  12.     Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.
    Ducani C, Kaul C, Moche M, Shih W, Högberg B
    Nat. Methods 2013 Jul;10(7):647-52
  13.     Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa.
    Jacewicz A, Izumi A, Brunner K, Schnell R, Schneider G
    PLoS ONE 2013 ;8(5):e63161
  14.     Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
    Quistgaard E, Löw C, Moberg P, Trésaugues L, Nordlund P
    Nat. Struct. Mol. Biol. 2013 Jun;20(6):766-8
  15.     Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
    Lim S, Chen D, Teo H, Roos A, Jansson A, Nyman T, et al
    J. Lipid Res. 2013 Jun;54(6):1630-43
  16.     The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.
    Biterova E, Svärd M, Possner D, Guy J
    J. Mol. Biol. 2013 Jun;425(12):2208-18
  17.     Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
    Böth D, Steiner E, Stadler D, Lindqvist Y, Schnell R, Schneider G
    Acta Crystallogr. D Biol. Crystallogr. 2013 Mar;69(Pt 3):432-41
  18.     Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
    Forst A, Karlberg T, Herzog N, Thorsell A, Gross A, Feijs K, et al
    Structure 2013 Mar;21(3):462-75
  19.     Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
    Oja T, Niiranen L, Sandalova T, Klika K, Niemi J, Mäntsälä P, et al
    Proc. Natl. Acad. Sci. U.S.A. 2013 Jan;110(4):1291-6
  20.     The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
    Moynie L, Schnell R, McMahon S, Sandalova T, Boulkerou W, Schmidberger J, et al
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2013 Jan;69(Pt 1):25-34


2012 publications

  1.     Crystal structure of NirD, the small subunit of the nitrite reductase NirbD from Mycobacterium tuberculosis at 2.0 Å resolution.
    Izumi A, Schnell R, Schneider G
    Proteins 2012 Dec;80(12):2799-803
  2.     Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
    Allerbring E, Duru A, Uchtenhagen H, Madhurantakam C, Tomek M, Grimm S, et al
    Eur. J. Immunol. 2012 Nov;42(11):2990-3000
  3.     Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
    Andersson C, Karlberg T, Ekblad T, Lindgren A, Thorsell A, Spjut S, et al
    J. Med. Chem. 2012 Sep;55(17):7706-18
  4.     High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.
    Quistgaard E, Nordlund P, Löw C
    FASEB J. 2012 Oct;26(10):4003-13
  5.     Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.
    Löw C, Jegerschöld C, Kovermann M, Moberg P, Nordlund P
    PLoS ONE 2012 ;7(6):e38244
  6.     Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.
    Egeblad L, Welin M, Flodin S, Gräslund S, Wang L, Balzarini J, et al
    PLoS ONE 2012 ;7(5):e37724
  7.     Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
    Madhurantakam C, Duru A, Sandalova T, Webb J, Achour A
    PLoS ONE 2012 ;7(3):e32805
  8.     Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.
    Schnell R, Oehlmann W, Sandalova T, Braun Y, Huck C, Maringer M, et al
    PLoS ONE 2012 ;7(2):e31133
  9.     Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
    Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell A, et al
    Nat. Biotechnol. 2012 Feb;30(3):283-8
  10.     High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
    Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, et al
    Proc. Natl. Acad. Sci. U.S.A. 2012 Feb;109(7):2325-9

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