MBB Keynote Lecture: Heiko Hermeking, Ludwig Maximilian University München, Germany
Title: "Mutual regulation of microRNAs and transcription factors in the progression of colon cancer"
Prof. Hermeking has uncovered important targets and functions of the microRNA miR-34a in cancer and aging. He has increased our understanding of important regulators of cancer including such as c-Myc and p53.
IL-‐6R/STAT3/miR-‐34a feedback loop promotes EMT‐mediated colorectal cancer invasion and metastasis, J Clin Invest. 2014
MicroRNA‐34a regulates cardiac ageing and function. Nature 2013
The c‐Myc oncoprotein, the NAMPT enzyme, the SIRT1‐inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. PNAS 2012
Mediation of c‐Myc-induced apoptosis by p53. Science 1994