Guest lecture by Shigehiro Kuraku: ”Asymmetric evolution of paralogs in vertebrate genomes”
Guest lecture by Shigehiro Kuraku in collabortaion with the Japanese Society for the Promotion of Sciences (JSPS).
Shigehiro Kuraku started his career in the field of molecular phylogenetics and later got involved in developmental biology for his PhD. He held an assistant professorship in University of Konstanz, Germany, where he mainly worked on genome informatics. Since 2012, he has been working in RIKEN Kobe, Japan, to conduct his original research on jawless fishes and cartilaginous fishes, while managing an integrative genome analysis station with an in-house DNA sequencing facility.
Our genome contains thousands of genes that are classified into hundreds of gene families. Gene families expand and shrink through gene duplication and loss, which have shaped the molecular basis of complex mechanisms governing biological processes. So far, the determinant of the fates of duplicated genes have been imputed to variable constraints on their biological functions. Utilizing emerging genome sequence information for several early vertebrates produced in-house, we focused on vertebrate genes that duplicated in the chordate lineage, and analyzed their molecular phylogeny, dispositions in the genome, and expression profiles. Our results indicated an alternative explanation for biased retention of duplicated genes and their asymmetric functional evolution.
Sten Linnarsson, Karolinska Institutet
Takao Yoshihara, Deputy Director JSPS
Koari Okamoto, International Program Associate JSPSContact person: Sten Linnarsson